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Tyrosine kinase inhibitors in glioblastoma

Molecular pathway for oxidative stress

Thyroid hormones production and peripheral downstream signaling effects

Integrated breast cancer pathway

Somatroph axis (GH) and its relationship to dietary restriction and aging

De novo biosynthesis of pyrimidine ribonucleotides

Transcriptional regulation of memory B cell differentiation

Regulation of cytotoxic T cell responses by Malat1 - miR-15/16 circuit

Hallmark of cancer: non-mutational epigenetic reprogramming

Hallmark of cancer: sustaining proliferative signaling

Omega-3-fatty acids in senescence

Mammary gland development: pregnancy and lactation - stage 3 of 4

Dravet syndrome

De novo biosynthesis of purine nucleotides

Type I interferon induction and signaling during SARS-CoV-2 infection

Type 2 papillary renal cell carcinoma

Fatty acid and lipoprotein transport in hepatocytes

Kallmann syndrome

NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence

miR-targeted genes in squamous cell

miR-targeted genes in muscle cell

miR-targeted genes in lymphocytes

miR-targeted genes in adipocytes

Small cell lung cancer

Sulfate assimilation pathway

TCA cycle - detailed

Tyrosine biosynthesis

Pantothenate and coenzyme A biosynthesis

Homocysteine and cysteine interconversion

MAPK signaling pathway

Steroidogenic pathway

Threonine and methionine biosynthesis

De novo biosynthesis of pyrimidine deoxyribonucleotides

Threonine biosynthesis

Glycolysis

Glutamate biosynthesis superpathway

Superpathway of branched chain amino acid biosynthesis

Metabolic pathway of LDL, HDL and TG, including diseases

Histidine, purine, and pyrimidine superpathway

Isoleucine biosynthesis

Valine biosynthesis

B cell receptor signaling

Glutamate degradation I

Glutamate degradation IX

Triglyceride biosynthesis

Isoleucine degradation

Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids

Vitamin K metabolism and activation of dependent proteins

Statin inhibition of cholesterol production

Lipid metabolism pathway

Chorismate biosynthesis

Gastrin signaling

Glutathione-glutaredoxin redox reaction

Pyrimidine ribonucleotide salvage pathways

Fatty acid oxidation

Asparagine biosynthesis

De novo NAD biosynthesis

Arginine degradation

Histidine biosynthesis

Pyruvate dehydrogenase pathway

Glycolysis and Gluconeogenesis

Dauer formation

Mitochondrial unfolded-protein response

Copper homeostasis

Programmed cell death

Sex determination

Wnt signaling - Q neuroblast migration

ER stress-unfolded protein response (UPRer)

RTK/Ras/MAPK - LET-23, EGL-15 independent

Male mating

Sulfide oxidation pathway

Regulation of immune response in the intestine

Programmed cell death and cell engulfment

Left-right asymmetry in the nervous system

Heterochronic gene regulation of development

Cell engulfment

Ascaroside biosynthesis

Wnt signaling in cell polarity

EGF signaling in vulval development

Notch signaling in vulval development

Mechanosensory inputs influence pharyngeal activity via ivermectin sensitivity genes

daf-2 or insulin signaling pathway

Hedgehog-related genes

TOR signaling

Vulval development

Cell division: first embryonic mitosis

Biogenic amine synthesis

Vulval development and SynMuv

RNA interference and miRNA

Role of lipid metabolism

Programmed cell death and cell engulfment

Wnt signaling

Aging

Metapathway signal transduction

LIN-12/Notch Lateral Signaling

Glucocorticoid effect on target gene expression

Pentose phosphate metabolism

Phase I biotransformations, non-P450

Principal pathways of carbon metabolism

Cancer pathways

AMP-activated protein kinase signaling

JAK-STAT signaling in the regulation of beta cells

Cholesterol metabolism

COVID-19 adverse outcome pathway

Follicle stimulating hormone (FSH) signaling

IL5 signaling

Cholesterol biosynthesis pathway in hepatocytes

Arsenic metabolism and reactive oxygen species generation

Nucleotide excision repair in xeroderma pigmentosum

Familial hyperlipidemia type 2

DNA IR-double strand breaks and cellular response via ATM

Lysine biosynthesis

T-cell activation SARS-CoV-2

Orexin receptor pathway

Neuroinflammation and glutamatergic signaling

Burn wound healing

Trans-sulfuration, one-carbon metabolism and related pathways

Irinotecan pathway

T-cell receptor signaling

Osteoarthritic chondrocyte hypertrophy

Estradiol regulation in porto-sinusoidal vascular disease

Melanoma

Synaptic signaling associated with autism spectrum disorder

Nonalcoholic fatty liver disease

Ras signaling

Chromosomal and microsatellite instability in colorectal cancer

Clear cell renal cell carcinoma pathways

Hepatitis C and hepatocellular carcinoma

Focal adhesion

Glucocorticoid receptor pathway

Spinal cord injury

Leptin signaling

IL1 signaling

Androgen receptor signaling

3q29 copy number variation syndrome

Endoplasmic reticulum stress response in coronavirus infection

HDAC6 interactions in the central nervous system

Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex

Vitamin D in inflammatory diseases

Neovascularization processes

PI3K/AKT/mTOR - vitamin D3 signaling

Nuclear receptors

Vitamin B12 metabolism

Tamoxifen metabolism

T cell receptor and co-stimulatory signaling

UDP-glucose conversion

Selenium metabolism / selenoproteins

Toll-like receptor signaling

Vitamin A1 and A5/X pathways

Ovarian infertility

GPR143 in melanocytes and retinal pigment epithelium cells

CAMKK2 pathway

LTF danger signal response pathway

Non-genomic actions of 1,25-dihydroxyvitamin D3

Pathways affected in adenoid cystic carcinoma

Serotonin receptor 2 and ELK-SRF/GATA4 signaling

Sudden infant death syndrome (SIDS) susceptibility pathways

GNAQ pathways in port-wine stain

Calcium regulation in cardiac cells

Macrophage-stimulating protein (MSP) signaling

Activation of NLRP3 inflammasome by SARS-CoV-2

Renin-angiotensin-aldosterone system (RAAS)

NAD biosynthesis II from tryptophan

MAPK pathway in congenital thyroid cancer

G1 to S cell cycle control

ncRNAs in Wnt signaling in hepatocellular carcinoma

Mitochondrial complex I assembly model OXPHOS system

Thermogenesis

Ferroptosis

Pancreatic adenocarcinoma pathway

PI3K-Akt signaling

Imatinib and chronic myeloid leukemia

IL6 signaling

Thymic stromal lymphopoietin (TSLP) signaling

TP53 network

FGFR4 p.G388R signaling

Estrogen metabolism

Docosahexaenoic acid oxylipin metabolism

N-glycan biosynthesis

Interactions of natural killer cells in pancreatic cancer

Fluoroacetic acid toxicity

16p11.2 proximal deletion syndrome

Major receptors targeted by epinephrine and norepinephrine

Metabolism of alpha-linolenic acid

Cancer immunotherapy by PD-1 blockade

Blood clotting and drug effects

MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

Cysteine and methionine catabolism

Ophthalmate biosynthesis in hepatocytes

Control of immune tolerance by vasoactive intestinal peptide

Relationship between inflammation, COX-2 and EGFR

Platelet-mediated interactions with vascular and circulating cells

Estrogen receptor pathway

Pathophysiological roles of DUX4 in FSHD1

Th17 cell differentiation pathway

Network map of SARS-CoV-2 signaling

SARS coronavirus and innate immunity

Purinergic signaling

Mammalian disorder of sexual development

NPHP1 deletion syndrome

TAR syndrome

Kleefstra syndrome

Female steroid hormones in cardiomyocyte energy metabolism

2q37 copy number variation syndrome

2q13 copy number variation syndrome

DYRK1A involvement regarding cell proliferation in brain development

15q13.3 copy number variation syndrome

15q11.2 copy number variation syndrome

7q11.23 copy number variation syndrome

Unfolded protein response

1q21.1 copy number variation syndrome

Peroxiredoxin 2 induced ovarian failure

Regucalcin in proximal tubule epithelial kidney cells

Purine metabolism

Prader-Willi and Angelman syndrome

ADHD and autism (ASD) pathways

8q11.23 (RB1CC1) copy number variation

15q25 copy number variation

15q11q13 copy number variation

13q12.12 copy number variation

10q22q23 copy number variation

5q35 copy number variation

17p13.3 (YWHAE) copy number variation

4p16.3 copy number variation

Affected pathways in Duchenne muscular dystrophy

Lactate shuttle in glial cells

17q12 copy number variation syndrome

Mineralocorticoid biosynthesis

Neurogenesis regulation in the olfactory epithelium

Cholestasis

Bardet-Biedl syndrome

Hippocampal synaptogenesis and neurogenesis

Thyroid hormone imbalance leading to neurodevelopmental abnormalities

Amino acid metabolism in triple-negative breast cancer cells

Glucose metabolism in triple-negative breast cancer cells

SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction

Roles of ceramides in development of insulin resistance

Disorders of fructose metabolism

Spina bifida

Mitochondrial fatty acid oxidation disorders

Familial hyperlipidemia type 4

Meta pathway lipodystrophy, dyslipidemia and hyperlipidemia

Fatty acid transporters

Genes associated with the development of rheumatoid arthritis

Phosphoinositides metabolism

Galanin receptor pathway

p53 transcriptional gene network

Complement system

Mitochondrial long chain fatty acid beta-oxidation

Aflatoxin B1 metabolism

Glucuronidation

Estrogen metabolism

Arylamine metabolism

Arachidonate epoxygenase / epoxide hydrolase

Oxidative phosphorylation

Type II interferon signaling

Interferon type I signaling

Exercise-induced circadian regulation

Complement and coagulation cascades

Wnt/Beta-catenin signaling inhibitors in current and past clinical trials

Omega-6-fatty acids in senescence

DNA adduct formation leading to kidney failure

Smith-Magenis and Potocki-Lupski syndrome copy number variation

NF1 copy number variation syndrome

11p11.2 copy number variation syndrome

8p23.1 copy number variation syndrome

1p36 copy number variation syndrome

Autophagy in pancreatic ductal adenocarcinoma

Male steroid hormones in cardiomyocyte energy metabolism

Isoglobo series sphingolipids

Sildenafil treatment

Glycosphingolipid metabolism

Disorders of galactose metabolism

Complement system in neuronal development and plasticity

T cell modulation in pancreatic cancer

Burn wound healing

Burn wound healing

Kynurenine pathway and links to cell senescence

Pentose phosphate pathway in senescent cells

SARS-CoV-2 innate immunity evasion and cell-specific immune response

Airway smooth muscle cell contraction

TCA cycle

Overlap between signal transduction pathways contributing to LMNA laminopathies

Hijack of ubiquitination by SARS-CoV-2

Influence of laminopathies on Wnt signaling

Peroxiredoxin 2 induced ovarian failure

Vitamin D-sensitive calcium signaling in depression

Joubert syndrome

Aerobic glycolysis

Triacylglyceride synthesis

ESC pluripotency pathways

Post-COVID neuroinflammation

Catabolism of skeletal muscle in cachexia

FOXP3 in COVID-19

Mitochondrial immune response to SARS-CoV-2

Aspirin and miRNAs

Aerobic glycolysis - augmented

Fragile X syndrome

Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism

Biotic stress response gene network

Rett syndrome

Acute viral myocarditis

Flavan-3-ol metabolic pathway

Purine metabolism and related disorders

Ebola virus infection in host

Embryonic stem cell pluripotency pathways

Angiopoietin-like protein 8 regulatory pathway

Dengue-2 interactions with complement and coagulation cascades

Nanomaterial-induced inflammasome activation

AtMetExpress overview

Zinc homeostasis

Pluripotent stem cell differentiation pathway

Folate metabolism

Effect of omega-3 PUFA on Huntington's disease pathways

IL-1 signaling pathway

Endothelin pathways

Differentiation pathway

Interferon type I signaling pathways

Quercetin and Nf-kB / AP-1 induced cell apoptosis

NOD pathway

Mitochondrial gene expression

Monoamine transport

Hair follicle development: cytodifferentiation - stage 3 of 3

Quercetin and Nf-kB / AP-1 induced apoptosis

DNA damage response (only ATM dependent)

ROS in COVID-19 endothelial dysfunction

Immune response to tuberculosis

ApoE and miR-146 in inflammation and atherosclerosis

Seed development

Androgen receptor network in prostate cancer

Immune responses in the epidermis

Seed development

Oxylipins pathways

Endothelin pathways

RANKL/RANK signaling

Nucleotide-binding oligomerization domain (NOD) pathway

Folic acid network

Nod-like receptor (NLR) signaling pathway

EBV LMP1 signaling

Folic acid network

Mitochondrial gene expression

Nod-like receptor (NLR) signaling pathway

Arachidonate epoxygenase / epoxide hydrolase

EBV LMP1 signaling

EBV LMP1 signaling

Heme biosynthesis

Heme biosynthesis

Complement and coagulation cascades

IL-4 signaling pathway

Nod-like receptor (NLR) signaling pathway

Arachidonate epoxygenase / epoxide hydrolase

Monoamine transport

Vitamin A and carotenoid metabolism

MAPK cascade

FTO obesity variant mechanism

RAC1/PAK1/p38/MMP2 pathway

Statin pathway

Sulfur amino acid biosynthesis

Folate metabolism

Neurotransmitter release in cholinergic motor neurons

Sucrose biosynthesis

Electron transport chain: OXPHOS system in mitochondria

Histidine metabolism

Nutrient control of ribosomal gene expression

Phosphodiesterases in neuronal function

Polycystic kidney disease pathway

Inflammatory bowel disease signaling

miRNA regulation of prostate cancer signaling

Folic acid biosynthesis

Common pathways underlying drug addiction

Pilocytic astrocytoma

Estrogen signaling

ErbB signaling

Notch signaling

FLT3 p.Gln640SerfsTer8 signaling

IL19 signaling

TGFB / Smad signaling

IL26 signaling

Cardiomyocyte signaling converging on titin

Induction of autophagy and toll-like receptor signaling by graphene oxide

ID signaling

G13 signaling

Urotensin-II-mediated signaling

CCL18 signaling

IL2 signaling

PKC-gamma calcium signaling in ataxia

IL18 signaling

Netrin-UNC5B signaling

Hedgehog signaling

IL10 anti-inflammatory signaling

EGF/EGFR signaling

Fibrin complement receptor 3 signaling

p38 MAPK signaling

Wnt signaling and pluripotency

IL4 signaling

MAPK and NFkB signaling inhibited by Yersinia YopJ

MAPK signaling

Wnt signaling

Kit receptor signaling

Nod-like receptor (NLR) signaling

IL3 signaling

ATM signaling

Alpha 6 beta 4 signaling

Brain-derived neurotrophic factor (BDNF) signaling

Oncostatin M signaling

Corticotropin-releasing hormone signaling

IL11 signaling

TNF-alpha signaling

Glioblastoma signaling

IL9 signaling

IL7 signaling

Prolactin signaling

TNF-related weak inducer of apoptosis (TWEAK) signaling

Thyroid stimulating hormone (TSH) signaling

Resolvin E1 and resolvin D1 signaling decrease inflammation

Triacylglyceride synthesis

Hepatitis B infection

H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer

Bile acid synthesis and enterohepatic circulation

Statin pathway

Selenium metabolism and selenoproteins

One-carbon metabolism

Prion disease pathway

Metabolism of T-2 toxin and HT-2 toxin

Metabolic epileptic disorders

Sulfur degradation

Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins

DNA replication

Monoamine GPCRs

Monoamine GPCRs

SARS-CoV-2 replication organelle formation

Type I collagen synthesis in the context of osteogenesis imperfecta

Head and neck squamous cell carcinoma

Oligodendrocyte specification and differentiation, leading to myelin components for CNS

Extracellular vesicles in the crosstalk of cardiac cells

MET in type 1 papillary renal cell carcinoma

Biosynthesis of the three types of mycolic acids

Genes targeted by miRNAs in adipocytes

STING pathway in Kawasaki-like disease and COVID-19

Mitochondrial complex I inhibition leading to chemical-induced Fanconi syndrome

Lipids measured in liver metastasis from breast cancer

Degradation pathway of sphingolipids, including diseases

Mecp2 and associated Rett syndrome

Ectodysplasin A signaling in hair follicle development

Wnt myofibroblastic activation of hepatic stellate cells

GLP-1 secretion from intestine to portal vein

Cytokines and inflammatory response

Extrafollicular and follicular B cell activation by SARS-CoV-2

Thiamine metabolic pathways

Heme biosynthesis

GLP-1 from intestine and pancreas and role in glucose homeostasis

GLP-1 in pancreatic islet cells

mRNA vaccine activation of dendritic cell and induction of IFN-1

Measles virus infection

Altered glycosylation of MUC1 in tumor microenvironment

Suppression of HMGB1-mediated inflammation by THBD

Ethanol metabolism production of ROS by CYP2E1

Ethanol metabolism resulting in production of ROS by CYP2E1

Poly(glycerol phosphate) wall teichoic acid biosynthesis

Intracellular auxin transport

Glial cell differentiation

Dopaminergic neurogenesis

Metapathway UDP-glucuronosyltransferases

RAS and bradykinin pathways in COVID-19

Mitochondrial complex inhibition leading to liver injury

Gastric acid production

Serotonin and anxiety-related events

Downregulation of ACE2 by SARS-CoV-2 spike protein

Physiological and pathological hypertrophy of the heart

TCA cycle (aka Krebs or citric acid cycle)

Oxidative stress response

Wnt signaling pathway

ATM signaling in development and disease

Steroid biosynthesis

Hypothesized pathways in pathogenesis of cardiovascular disease

Glutathione metabolism

TGF-beta receptor signaling in skeletal dysplasias

FGF23 signaling in hypophosphatemic rickets and related disorders

Autosomal recessive osteopetrosis pathways

Proteoglycan biosynthesis

Endochondral ossification

Effect of progerin on genes involved in progeria

Lamin A processing pathway

DNA damage response

10q11.21q11.23 copy number variation syndrome

Hypoxia-dependent differentiation of myoblasts

Hypoxia-dependent self-renewal of myoblasts

Kisspeptin/kisspeptin receptor system in the ovary

Pathways of nucleic acid metabolism and innate immune sensing

22q11.2 copy number variation syndrome

Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors

miRNA role in immune response in sepsis

miRNA regulation of p53 pathway in prostate cancer

Dysregulated miRNA targeting in insulin/PI3K-AKT signaling

Cell-type dependent selectivity of CCK2R signaling

SIDS susceptibility pathways

Focal adhesion: PI3K-Akt-mTOR signaling pathway

N-glycan biosynthesis

DNA replication

Flowering time pathway

Oxytocin signaling

Flowering time pathway

One-carbon metabolism

Thyroxine (thyroid hormone) production

TCA cycle

GABA receptor signaling

Mammary gland development pathway - Involution (Stage 4 of 4)

Mammary gland development pathway - Puberty (Stage 2 of 4)

Mammary gland development pathway - Embryonic development (Stage 1 of 4)

Host-pathogen interaction of human coronaviruses - interferon induction

Drug induction of bile acid pathway

Breast cancer pathway

Drug induction of bile acid pathway

TCA cycle nutrient use and invasiveness of ovarian cancer

Irinotecan pathway

Irinotecan pathway

Angiotensin II receptor type 1 pathway

Evolocumab mechanism to reduce LDL cholesterol

Adverse outcome pathway for mitochondrial complex 1 (C1) inhibition

4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression

Regulation of apoptosis by parathyroid hormone-related protein

Vitamin D metabolism

Endometrial cancer

ACE inhibitor pathway

7-oxo-C and 7-beta-HC pathways

Alternative pathway of fetal androgen synthesis

Angiogenesis

Enterohepatic circulation of bile acids

Steroid hormone precursor biosynthesis

Cholesterol biosynthesis with skeletal dysplasias

Oxysterols derived from cholesterol

Disorders of folate metabolism and transport

Bladder cancer

Riboflavin and CoQ disorders

Linoleic acid metabolism affected by SARS-CoV-2

Vitamin B6-dependent and responsive disorders

Neurotransmitter disorders

Metabolism of sphingolipids in ER and Golgi apparatus

Cell lineage map for neuronal differentiation

Growth factors and hormones in beta cell proliferation

Genetic causes of porto-sinusoidal vascular disease

16p11.2 distal deletion syndrome

Cellular proteostasis

Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway

Histone modifications

Biotin metabolism

Type II diabetes mellitus

Chronic hyperglycemia impairment of neuron function

Complement-mediated inflammation of pulmonary alveolus in COVID-19 (hypothetical pathway)

COVID-19 structural coverage map

Parkinson's disease pathway

Ether lipid biosynthesis

Disorders of bile acid synthesis and biliary transport

Disorders in ketone body synthesis

Glyoxylate metabolism

Ethylmalonic encephalopathy

FGFR3 signaling in chondrocyte proliferation and terminal differentiation

Urea cycle and associated pathways

Urea cycle and related diseases

Glycosylation and related congenital defects

Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases

Molybdenum cofactor (Moco) biosynthesis

Methionine metabolism leading to sulfur amino acids and related disorders

MTHFR deficiency

Vitamin B12 disorders

Krebs cycle disorders

Pyrimidine metabolism and related diseases

GABA metabolism (aka GHB)

MECP2 and associated Rett syndrome

Complement activation

Proline and hydroxyproline pathways

Cerebral organic acidurias, including diseases

Tyrosine metabolism and related disorders

Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine

Copper homeostasis

Apoptosis

Codeine and morphine metabolism

Cancer immunotherapy by CTLA4 blockade

Amyotrophic lateral sclerosis (ALS)

Cholesterol biosynthesis pathway

Apoptosis modulation and signaling

Fructose and mannose metabolism

KCNQ2-related epilepsies

Glycolysis and gluconeogenesis

Acetylcholine synthesis

Synaptic vesicle pathway

Alzheimer's disease and miRNA effects

Focal adhesion

Nucleotide GPCRs

Tryptophan metabolism

Monoamine GPCRs

Regulation of actin cytoskeleton

Prostaglandin signaling

Inflammatory response pathway

Fatty acid omega-oxidation

Notch signaling pathway

Fatty acid beta-oxidation 3

Peptide GPCRs

RIOK1 and RIOK2 in EGFR- and PI3K-mediated tumorigenesis

T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection

Glycine metabolism, including IMDs

Canonical and non-canonical Notch signaling

Sterol regulatory element-binding proteins (SREBP) signaling

High-osmolarity glycerol (HOG) pathway

Metapathway biotransformation Phase I and II

Interleukin-1 (IL-1) structural pathway

Non-small cell lung cancer

Methionine de novo and salvage pathway

Non-canonical Wnt pathway

Hematopoietic stem cell gene regulation by GABP alpha/beta complex

Purine metabolism

Blood clotting cascade

Glycolysis in senescence

Carnosine metabolism of glial cells

Primary ovarian insufficiency

Kennedy pathway from sphingolipids

Biosynthesis of anthocyanins from phenylalanine in purple corn

lncRNA in canonical Wnt signaling and colorectal cancer

Pleural mesothelioma

Wnt signaling

Cell cycle

Transcriptional activation by NRF2 in response to phytochemicals

EGFR tyrosine kinase inhibitor resistance

Gibberellin A12 biosynthesis

Warburg effect modulated by deubiquitinating enzymes and their substrates

Alanine and aspartate metabolism

Representative anthocyanin biosynthetic pathway

D-arginine and D-ornithine metabolism

Diet-dependent trimethylamine/trimethylamine N-oxide metabolism

Osteoblast signaling

Genetic alterations of lung cancer

Nuclear receptors meta-pathway

Nicotine effect on chromaffin cells

Osteoclast signaling

Ergosterol biosynthesis

Glycerophospholipid biosynthetic pathway

Comprehensive IL-17A signaling

Aryl hydrocarbon receptor pathway

Eicosanoid metabolism via cyclooxygenases (COX)

Abnormal calcium handling and its effects on muscle contraction in DMD

Integrated cancer pathway

VEGF-receptor signal transduction

VEGFR-3 signaling

Cori cycle

Peroxisomal beta-oxidation of tetracosanoyl-CoA

Kennedy pathway

Mechanisms associated with pluripotency

Iron homeostasis

Folate-alcohol and cancer pathway hypotheses

Transcription factors regulate miRNAs related to cardiac hypertrophy

MicroRNAs in cardiomyocyte hypertrophy

Energy metabolism

Flavonoid biosynthesis

miRNA regulation of DNA damage response

Regulation of cardiac hypertrophy by miR-208

Oxidative damage response

Glycine metabolism

Opioid receptor pathways

White fat cell differentiation

Dopaminergic neurogenesis

AGE/RAGE pathway

Heart development

Nicotine effect on dopaminergic neurons

Fluoropyrimidine activity

Mitochondrial long chain fatty acid beta-oxidation

Parkinson's disease

Target of rapamycin signaling

Photosynthetic carbon reduction

Serotonin transporter activity

VEGFA-VEGFR2 signaling

Apoptosis modulation by HSP70

Osteoblast signaling

Notch signaling

Small ligand GPCRs

Response regulator aspartate phosphatase interactions

Pyrimidine metabolism

Adipogenesis genes

mRNA processing

Eukaryotic transcription initiation

Fas ligand pathway and stress induction of heat shock proteins

Nuclear receptors in lipid metabolism and toxicity

Myometrial relaxation and contraction pathways

S1P receptor signal transduction

CFTR activity in the plasma membrane

TNF-alpha and mucus production in lung epythelium

Intracellular trafficking of CFTR

Interactions between CFTR and other ion channels

Osteopontin signaling

Homologous recombination

Integrin-mediated cell adhesion

Bone morphogenic protein signaling and regulation

Translation factors

TGF-beta receptor signaling

Biogenic amine synthesis

Hypertrophy model

Sulfation biotransformation reaction

Glucose homeostasis

Abscisic acid biosynthesis

Flower development

Glycogen synthesis and degradation

Prostaglandin synthesis and regulation

Omega-9 fatty acid synthesis

Eicosanoid metabolism via lipoxygenases (LOX)

Fructose metabolism in proximal tubules

Elongation of (very) long chain fatty acids

Globo series sphingolipid metabolism

Bacterial ceramide synthesis

Serotonin receptor 4/6/7 and NR3C signaling

Serotonin HTR1 group and FOS pathway

Serotonin transporter activity

Serotonin receptor 4/6/7 and NR3C signaling

Serotonin receptor 2 and ELK-SRF / GATA4 signaling

Serotonin receptor 2 and STAT3 signaling

Serotonin receptor 2 and STAT3 signaling

IL-9 signaling pathway

IL-6 signaling pathway

Metabolic pathways of fibroblasts

Protein alkylation leading to liver fibrosis

Cysteine biosynthesis from homoserine

Osteoclast signaling

GPCRs, class A rhodopsin-like

Nuclear factor, erythroid-derived 2, like 2 signaling pathway

Colanic acid building blocks biosynthesis

Response to acute ibuprofen exposure

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Mevalonate pathway

Glycerophospholipid biosynthetic pathway

Wnt signaling pathway and pluripotency

Glycerol teichoic acid biosynthesis

Catecholamine synthesis

Oxidative stress and redox pathway

Metabolism of tetrahydrocannabinol (THC)

SK UDPglcnac

Cardiac progenitor differentiation

Primary carbon metabolism

Pentose phosphate pathway

Glycolysis

Primary focal segmental glomerulosclerosis (FSGS)

Cardiolipin biosynthesis

DNA replication

Translation factors

Oxidation by cytochrome P450

Pentose phosphate pathway

Ethanol effects on histone modifications

Cholesterol metabolism with Bloch and Kandutsch-Russell pathways

Phospholipid biosynthesis

Ureide biosynthesis

Heme biosynthesis

TCA cycle in senescence

Deregulation of renin-angiotensin system by SARS-CoV infection

Neuroinflammation

Sphingolipid metabolism: integrated pathway

Omega-3 / omega-6 fatty acid synthesis

Eicosanoid metabolism via lipooxygenases (LOX)

Eicosanoid metabolism via cytochrome P450 monooxygenases pathway

Omega-3 / omega-6 fatty acid synthesis

Eicosanoid metabolism via cytochrome P450 monooxygenases

Eicosanoid metabolism via cyclooxygenases (COX)

Glycerolipids and glycerophospholipids

Sphingolipid metabolism overview

Fatty acid beta-oxidation 1

Pregnane X receptor pathway

Brassinolide biosynthetic pathway

Heme biosynthesis

Eicosanoid synthesis

Fatty acid elongation, unsaturated

Selenium micronutrient network

Fatty acid beta-oxidation

Retinol metabolism

Fatty acid beta-oxidation

Retinol metabolism

Triacylglyceride synthesis

Dravet syndrome: Scn1a-A1783V point mutation model

COVID-19 and endothelial cell senescence

Mitochondrial beta-oxidation

Lac-Phe pathway

Lac-Phe pathway

Serotonin reuptake inhibitor response

Myometrial relaxation and contraction pathways

COVID-19, thrombosis and anticoagulation

TLR4 signaling and tolerance

Overview of nanoparticle effects

PDGF pathway

Non-classical role of vitamin D

Steroid biosynthesis

Retinoblastoma gene in cancer

Glycolysis and gluconeogenesis

Actin cytoskeleton regulation

Nucleotide GPCRs

FAS pathway and stress induction of HSP regulation

Selenium micronutrient network

Blood clotting cascade

Vitamin B12 metabolism

Selenium micronutrient network

Selenium micronutrient network

Tryptophan degradation via kynurenine

IL1 and megakaryocytes in obesity

Cells and molecules involved in local acute inflammatory response

HIPK2 in kidney fibrosis

DNA IR-damage and cellular response via ATR

TGF-beta signaling pathway

Melatonin metabolism and effects

Aryl hydrocarbon receptor pathway

GDNF signaling

SARS-CoV-2 and ACE2 receptor: molecular mechanisms

Wnt signaling pathway

Wnt signaling pathway

LDLRAD4 and what we know about it

SARS-CoV-2 and COVID-19 pathway

Wnt signaling pathway

BDNF pathway

MAPK signaling pathway

Cell cycle

Triacylglyceride synthesis

Wnt signaling pathway and pluripotency

Leptin and adiponectin

Arginine biosynthesis

Fibrin complement receptor 3 signaling pathway

Serine metabolism

Long-day flowering time pathway

Cell differentiation - index

Spinal cord injury

nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell

Beta-oxidation of unsaturated fatty acids

Mevalonate arm of cholesterol biosynthesis pathway with inhibitors

Trehalose degradation, low osmolarity

Effect of L-carnitine on metabolism

Cori cycle

Male infertility

Parkin-ubiquitin proteasomal system pathway

Vitamin D receptor pathway

Nanoparticle triggered regulated necrosis

Nod-like receptor (NLR) signaling pathway

Nicotine metabolism in liver cells

Prostaglandin and leukotriene metabolism in senescence

Gut-liver indole metabolism

Tryptophan metabolism

Biomarkers for pyrimidine metabolism disorders

Role of carnosine in muscle contraction

Hereditary leiomyomatosis and renal cell carcinoma pathway

Host-pathogen interaction of human coronaviruses - MAPK signaling

Oxidation by cytochrome P450

Primary focal segmental glomerulosclerosis (FSGS)

Familial partial lipodystrophy

Congenital generalized lipodystrophy

Ketogenesis and ketolysis

Biotin metabolism, including IMDs

Urea cycle and metabolism of amino groups

EGF/EGFR signaling pathway

Distal convoluted tubule 1 (DCT1) cell

Beta-oxidation of unsaturated fatty acids

Fatty acid beta-oxidation meta-pathway

Cytokinin signaling

Polar auxin transport

Wnt signaling pathway

Metabolic reprogramming in colon cancer

Ketone bodies synthesis and degradation

Nodal signaling pathway

BMP signaling pathway

Fatty acid beta-oxidation 2

Proteasome degradation

Mevalonate arm of cholesterol biosynthesis pathway

ERK1-ERK2 MAPK cascade

Caffeine and theobromine metabolism

Lung fibrosis

Flavonoid pathway

Pentose phosphate pathway

Differentiation of white and brown adipocyte

Mesodermal commitment pathway

Sucrose metabolism

Starch metabolism

Eukaryotic transcription initiation

miRNAs involved in DNA damage response

FGF signaling pathway

Sphingolipid pathway

Monoamine GPCRs

Cholesterol biosynthesis

Homologous recombination

Deregulation of Rab and Rab effector genes in bladder cancer

Folate biosynthesis

Alpha 6 beta 4 signaling pathway

Wnt signaling pathway and pluripotency

Pentose phosphate pathway

Calcium regulation in cardiac cells

Osteoclast signaling

IL-2 signaling pathway

PDGFR-alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine

TCA cycle

Eicosanoid lipid synthesis map

BMP signaling pathway in eyelid development

Interleukin-1 induced activation of NF-kB

Glycogen metabolism

Translation factors

Electron transport chain

Neural crest differentiation

GPCRs, class A rhodopsin-like

Endochondral ossification

SIDS susceptibility pathways

Catalytic cycle of mammalian flavin-containing monooxygenases (FMOs)

DNA mismatch repair

GPCRs, class C metabotropic glutamate, pheromone

DNA repair pathways, full network

Mitochondrial complex II assembly

Amino acid metabolism pathway excerpt: histidine catabolism extension

GPCRs, class A rhodopsin-like

Acrylamide biotransformation and exposure biomarkers

NO/cGMP/PKG mediated neuroprotection

BMP signaling in eyelid development

TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition

Toll-like receptor signaling related to MyD88

Physico-chemical features and toxicity-associated pathways

Tgif disruption of Shh signaling

lncRNA-mediated mechanisms of therapeutic resistance

Metabolism of dichloroethylene by CYP450

Biochemical pathways: part I

Lipid particles composition

GPCRs, class B secretin-like

Constitutive androstane receptor pathway

Hair follicle development: organogenesis - part 2 of 3

Felbamate metabolism

Cardiac hypertrophic response

Aripiprazole metabolic pathway

Sulindac metabolic pathway

Colchicine metabolic pathway

Diclofenac metabolic pathway

TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)

Gastric cancer network 2

Gastric cancer network 1

Deregulation of Rab and Rab effector genes in bladder cancer

Fatty acid omega-oxidation

SRF and miRs in smooth muscle differentiation and proliferation

GPCRs, other

Cytokines and inflammatory response

Prostaglandin synthesis and regulation

Nuclear receptors in lipid metabolism and toxicity

IL-9 signaling pathway

IL-2 signaling pathway

Small ligand GPCRs

Fatty acid omega-oxidation

IL-5 signaling pathway

Osteoblast signaling

Cholesterol biosynthesis

ACE inhibitor pathway

Ketone bodies synthesis and degradation

Cytokines and inflammatory response

T cell receptor and co-stimulatory signaling

Neural crest differentiation

Thyroxine (thyroid hormone) production

TWEAK signaling pathway

Thyroid stimulating hormone (TSH) signaling pathway

Aryl hydrocarbon receptor

ATM signaling pathway

Cell differentiation - index

PDGF pathway

TSLP signaling pathway

Spinal cord injury

Nicotine metabolism

Apoptosis modulation and signaling

Polar auxin transport

Isoprenoid precursor biosynthesis in Pf apicoplasts

IGF-1 signaling

Glyoxylate, anapleurotic and succinyl CoA (GAS) pathway

Transcription initiation by sigma factors

Escherichia coli K-12 peripherome

Momilactone biosynthesis

Beta-alanine biosynthesis

Carotenoid biosynthesis

Ganglio sphingolipid metabolism

Cholesterol biosynthesis

Statin pathway

ACE inhibitor pathway

Wnt signaling pathway and pluripotency

Electron transport chain

Cytokines and inflammatory response

IL-2 signaling pathway

Osteoblast signaling

Glycogen metabolism

Endochondral ossification

Notch signaling pathway

TGF-beta receptor signaling

TGF-beta signaling pathway

Acetylcholine synthesis

ACE inhibitor pathway

IL-3 signaling pathway

Notch signaling pathway

Glycolysis and gluconeogenesis

B cell receptor signaling pathway

Hedgehog signaling pathway

Wnt signaling pathway

Ketone bodies synthesis and degradation

IL-7 signaling pathway

Osteoclast signaling

Electron transport chain

NAD biosynthesis

Pentose phosphate pathway 2

Phenylalanine degradation

Glycolysis and gluconeogenesis

MAPK signaling pathway

Glycogen catabolism

Purine fermentation

Methionine degradation

Serine biosynthesis

Cell cycle and cell division

Trehalose anabolism

Riboflavin, FMN, and FAD biosynthesis

Fatty acid elongation, saturated

Pentose pathway, non-oxidative branch

Sphingolipid metabolism

Pentose phosphate pathway

Leucine degradation

Protein modifications

Glycine degradation

Allantoin degradation

Nucleotide metabolism

Tryptophan degradation

Polyamine biosynthesis

Upiquinone Q prenylation

Phenylalanine, tyrosine, and tryptophan biosynthesis

Starch and cellulose biosynthesis

Aerobic glycerol catabolism

Ribose and deoxyribose phosphate metabolism

Serine and glycine biosynthesis

Glutathione biosynthesis

Phenylalanine biosynthesis

P-cymene degradation

Leucine biosynthesis

NAD salvage pathway

Tryptophan biosynthesis

UDP-N-acetylgalactosamine biosynthesis

Fatty acid biosynthesis, initial steps

Cholesterol biosynthesis

DNA replication

mRNA processing

Wnt signaling pathway

Mitochondrial long chain fatty acid beta-oxidation

Triacylglycerol biosynthesis

Biosynthesis of gamma-aminobutyric acid (GABA) by polyamine oxidation

Genetic interactions between sugar and hormone signaling

TCA cycle (Krebs cycle)

Chlorophyll b degradation

Flower development: initiation

Glycogen metabolism

Cholesterol biosynthesis

Calcium regulation in cardiac cells

ACE inhibitor pathway

FAS pathway and stress induction of HSP regulation

Polyol pathway

GPR40 pathway

Neural crest differentiation

Wnt signaling pathway

FAS pathway and stress induction of HSP regulation

Heme biosynthesis

Steroid biosynthesis

IL-2 signaling pathway

ACE inhibitor pathway

Complement and coagulation cascades

Translation factors

Hedgehog signaling pathway

Osteoclast

Apoptosis modulation by HSP70

Oxidative damage response

Amino acid metabolism

Lipid droplet metabolism

Thick ascending limb transporters

Acetylcholine synthesis

IL-1 signaling pathway

Regulation of actin cytoskeleton

TCA cycle

Glucocorticoid metabolism

Proteasome degradation

Heme biosynthesis

Chicken limb development

Sulindac metabolic pathway

Notch signaling pathway

Focal adhesion

Proteasome degradation

Small ligand GPCRs

Proteasome degradation

Statin pathway

Hypothetical network for drug addiction

FAS pathway and stress induction of HSP regulation

Apoptosis modulation by HSP70

DNA replication

PPAR signaling pathway

Glycogen metabolism

Glycolysis and gluconeogenesis

MAPK signaling pathway

p38 MAPK signaling pathway

MAPK signaling pathway

p38 MAPK signaling pathway

Amino acid metabolism

Leptin-insulin signaling overlap

Synthesis and degradation of ketone bodies

Acetylcholine synthesis

ACE inhibitor pathway

ACE inhibitor pathway

Microglia pathogen phagocytosis pathway

MAPK signaling pathway

Target of rapamycin (TOR) signaling

G13 signaling pathway

p38 Mapk signaling pathway

Spinal cord injury

Cytokines and inflammatory response

Glycolysis and gluconeogenesis

Biogenic amine synthesis

Cholesterol biosynthesis

Electron transport chain

p38 MAPK signaling pathway

Cholesterol biosynthesis

MAPK signaling pathway

Ectoderm differentiation

Novel Jun-Dmp1 pathway

p38 Mapk signaling pathway

Mapk cascade

FOXA2 pathway

Renin-angiotensin system

Insulin signaling in adipocytes (diabetic condition)

Insulin signaling in adipocytes (normal condition)

Tyrobp causal network in microglia

Glutathione and one-carbon metabolism

Host-pathogen interaction of human coronaviruses - apoptosis

Host-pathogen interaction of human coronaviruses - autophagy

One-carbon metabolism

Metabolism overview

Retinoblastoma gene in cancer

One-carbon metabolism and related pathways

One-carbon metabolism

Lactose degradation and galactose metabolism

Disruption of postsynaptic signaling by CNV

EDA signaling in hair follicle development

BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation

Farnesoid X receptor pathway

PPAR-alpha pathway

Liver X receptor pathway

Endoderm differentiation

Alzheimer's disease

TNF-alpha signaling pathway

Peptidoglycan cytoplasmic synthesis and recycling pathways

Leptin signaling pathway

FSH signaling pathway

Androgen receptor signaling pathway

Kit receptor signaling pathway

Androgen receptor signaling pathway

ID signaling pathway

Androgen receptor signaling pathway

IL-6 signaling pathway

Butyrate-induced histone acetylation

Amyotrophic lateral sclerosis (ALS)

Wnt Signaling Pathway and Pluripotency

Alanine and aspartate metabolism

Monoamine GPCRs

Toll-like receptor signaling pathway

Peptide GPCRs

Cholesterol metabolism

Sulfate assimilation and copper detoxification

Lung fibrosis

RuMP cycle, oxidative branch of the pentose phosphate pathway and formaldehyde assimilation

Acetate mediated promotion of metabolic syndrome

Nanoparticle-mediated activation of receptor signaling

Nanomaterial induced apoptosis

Glycosaminoglycan degradation

Nuclear receptors in lipid metabolism and toxicity

Nuclear receptors in lipid metabolism and toxicity

Ptf1a related regulatory pathway

Tumor suppressor activity of SMARCB1

Hexoses metabolism in proximal tubules

Catalytic cycle of mammalian FMOs

Vanillin and isovanillin metabolism

Metastatic brain tumor

Aflatoxin B1 metabolism

Monoamine GPCRs

Biomarkers for urea cycle disorders

Nuclear receptors in lipid metabolism and toxicity

Ethanol metabolism resulting in production of ROS by CYP2E1

Angiotensin II signaling (acute) in thick ascending limbs

Cytosine methylation

Alanine and aspartate metabolism

Glutathione metabolism

Gonadotropin-releasing hormone (GnRH) signaling

Cocaine metabolism

Monoamine GPCRs

Lidocaine metabolism

Glucose-1-phosphate metabolism

Cadmium and glutathione

Relationship between glutathione and NADPH

Dopamine metabolism

Fatty acid oxidation

Geranylgeranyldiphosphate biosynthesis II (plastidic)

Oryzalexin S biosynthesis

Lycopene biosynthesis

Serotonin and anxiety-related events

Serotonin and anxiety

Splicing factor NOVA regulated synaptic proteins

Glutathione metabolism

Nuclear receptors in lipid metabolism and toxicity

Aflatoxin B1 metabolism

Glucuronidation

Glucuronidation

Nuclear receptors in lipid metabolism and toxicity

NRF2 pathway

Iron metabolism in placenta

Novel intracellular components of RIG-I-like receptor pathway

Caloric restriction and aging

Benzo(a)pyrene metabolism

Arylamine metabolism

Transcriptional activation by NRF2

Estrogen signaling pathway

Retinol metabolism

mRNA, protein, and metabolite inducation pathway by cyclosporin A

Benzene metabolism

Tryptophan metabolism

Biosynthesis and regulation of nematode bile acids

DON mycotoxin biosynthesis

Aflatoxin B1 metabolism

Monoamine GPCRs

Tryptophan metabolism

Estrogen metabolism

Transcription factor regulation in adipogenesis

Cytosolic DNA-sensing pathway

Butyrate-induced histone acetylation

Glutathione metabolism

Tryptophan metabolism

Calvin cycle

Iron uptake and transport

Gluconeogenesis

Dual hijack model of Vif in HIV infection

Adipogenesis

Phosphatidylcholine catabolism

Serotonin and anxiety

Nanoparticle triggered autophagic cell death

Methylerythritol phosphate pathway

Tryptophan catabolism leading to NAD+ production

G1 to S cell cycle control

Apoptosis

Lipoic acid metabolism

Ascorbate and aldarate metabolism

Heroin metabolism

Vitamin B9 (folate) biosynthesis pathway

Metapathway biotransformation

SCFA and skeletal muscle substrate metabolism

Glycine biosynthesis

Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling

Carbon monoxide dehydrogenase pathway

Toluene degradation

p53 signaling

eIF5A regulation in response to inhibition of the nuclear export system

Glycolysis

Xylulose-monophosphate cycle

Urea cycle and metabolism of amino groups

Toll-like receptor signaling pathway

Nucleotide GPCRs

Lipases biosynthesis

Octane oxidation