Prostaglandin signaling (WP5088)

Homo sapiens

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Prostaglandins are among the many inflammatory mediators that incite a cytokine storm in COVID-19 after bradykinin receptor B1 (BDKRB1) activation. This pathway mainly focuses on PGE2 and PGI2 and their interactions that lead to hyperinflammation via cytokine storms, immunothrombosis, and recruitment of fibrosis-mediating factors (VEGF, TGFB1, AREG). These pathways take place in multiple cell types, e.g. monocytes, macrophages, fibroblasts, Th17 cells, and Nk cells.

Authors

Aria Jadhav , Marvin Martens , Eric Weitz , and Egon Willighagen

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

macrophage natural killer cell fibroblast T-helper 17 cell plasmacytoid dendritic cell monocyte

Disease Ontology

COVID-19

Pathway Ontology

prostaglandin E2 signaling pathway prostaglandin I2 signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
cAMP Metabolite hmdb:HMDB0000058
Ca2+ efflux Metabolite chebi:29108
Prostaglandin E2 Metabolite cas:363-24-6
Prostaglandin I2 Metabolite cas:35121-78-9
IP-activated cAMP Metabolite hmdb:HMDB0000058
pro-IL1B GeneProduct ensembl:ENSG00000125538
IRF7 GeneProduct ensembl:ENSG00000185507
IFNA1 GeneProduct ensembl:ENSG00000197919
VEGFA GeneProduct ensembl:ENSG00000112715
IL6 GeneProduct ensembl:ENSG00000136244
CSF1 GeneProduct ensembl:ENSG00000184371
MMP9 GeneProduct ensembl:ENSG00000100985
IL17A GeneProduct ensembl:ENSG00000112115
IL8 GeneProduct ensembl:ENSG00000169429
IL1B GeneProduct ensembl:ENSG00000125538
CCL2 GeneProduct ensembl:ENSG00000108691
CXCL1 GeneProduct ensembl:ENSG00000163739
AREG GeneProduct ensembl:ENSG00000109321
TGFB1 GeneProduct hgnc.symbol:TGFB1
IL17F GeneProduct ensembl:ENSG00000112116
IL12A GeneProduct ensembl:ENSG00000168811
CXCL9 GeneProduct ensembl:ENSG00000138755
CXCL10 GeneProduct ensembl:ENSG00000169245
NFKB1 GeneProduct ensembl:ENSG00000109320
TNF GeneProduct ensembl:ENSG00000232810
IL1A GeneProduct ensembl:ENSG00000115008
CCL3 GeneProduct ensembl:ENSG00000277632
ASC GeneProduct ensembl:ENSG00000103490
NLRP3 GeneProduct ensembl:ENSG00000162711
pro-CASP1 GeneProduct ensembl:ENSG00000137752
CCR2 GeneProduct ensembl:ENSG00000121807
PI3K GeneProduct ensembl:ENSG00000105851
CD28 GeneProduct ensembl:ENSG00000178562
CASP1 GeneProduct ensembl:ENSG00000137752
Prostaglandin E2 receptor Protein uniprot:G3V2Y6
Prostaglandin E receptor 4 Protein ensembl:ENSG00000171522
PKA Protein kegg.genes:EC 2.7.11.11
AHR Protein ensembl:ENSG00000106546
IFNG Protein hgnc.symbol:IFNG
Natural killer cells antigen CD94 Protein uniprot:E9PCX9
Prostaglandin E synthase Protein uniprot:O14684
Prostaglandin E2 receptor Protein uniprot:P43116

References

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