Abnormal calcium handling and its effects on muscle contraction in DMD (WP5343)

Homo sapiens

Authors

Tom Bausch , Javier Millán Acosta , and Egon Willighagen

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Diseases

Annotations

Pathway Ontology

altered calcium/calcium-mediated signaling pathway disease pathway muscular disease pathway

Disease Ontology

Duchenne muscular dystrophy atrophic muscular disease muscular disease

References

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2. Regulation of the cardiac L-type Ca2+ channel by the actin-binding proteins alpha-actinin and dystrophin. Sadeghi A, Doyle AD, Johnson BD. Am J Physiol Cell Physiol. 2002 Jun;282(6):C1502-11. PubMed Europe PMC Scholia
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10. Protein assemblies of sodium and inward rectifier potassium channels control cardiac excitability and arrhythmogenesis. Willis BC, Ponce-Balbuena D, Jalife J. Am J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1463-73. PubMed Europe PMC Scholia
11. Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy. Allen DG, Whitehead NP, Froehner SC. Physiol Rev. 2016 Jan;96(1):253–305. PubMed Europe PMC Scholia
12. Critical Role of Intracellular RyR1 Calcium Release Channels in Skeletal Muscle Function and Disease. Hernández-Ochoa EO, Pratt SJP, Lovering RM, Schneider MF. Front Physiol. 2016 Jan 12;6:420. PubMed Europe PMC Scholia
13. IP3 receptor blockade restores autophagy and mitochondrial function in skeletal muscle fibers of dystrophic mice. Valladares D, Utreras-Mendoza Y, Campos C, Morales C, Diaz-Vegas A, Contreras-Ferrat A, et al. Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3685–95. PubMed Europe PMC Scholia
14. Abnormal Calcium Handling in Duchenne Muscular Dystrophy: Mechanisms and Potential Therapies. Mareedu S, Million ED, Duan D, Babu GJ. Front Physiol. 2021 Apr 9;12:647010. PubMed Europe PMC Scholia
15. Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4. Wang S, Li B, Solomon V, Fonteh A, Rapoport SI, Bennett DA, et al. Mol Neurodegener. 2022 Jun 15;17(1):42. PubMed Europe PMC Scholia