Eicosanoid metabolism via cyclooxygenases (COX) (WP4347)

Mus musculus

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This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps] and extended with the top left side of Figure 1 from Dennis and Norris (2015 [https://www.ncbi.nlm.nih.gov/pubmed/26139350]). Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349]. This pathway visualises the first route, via COX, where additonal colours have been used to visualise which conversions are being performed by the same enzymes. Green and orange boxes represent receptors, where the orange colour depicts peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.

Authors

Eoin Fahy , Ryan Miller , Denise Slenter , Egon Willighagen , Eric Weitz , and Conroy lipids

Activity

last edited

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Organisms

Mus musculus

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology

cyclooxygenase mediated pathway of arachidonic acid metabolism inflammatory response pathway arachidonic acid metabolic pathway eicosanoid metabolic pathway eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma eicosanoid signaling pathway eicosanoid biosynthetic pathway eicosanoid biosynthetic pathway

Participants

Label Type Compact URI Comment
PGC2 Metabolite lipidmaps:LMFA03010133
PGB2 Metabolite lipidmaps:LMFA03010018
Glycerophospholipids Metabolite chebi:37739
Arachidonic acid Metabolite lipidmaps:LMFA01030001
PGG2 Metabolite lipidmaps:LMFA03010009
PGH2 Metabolite lipidmaps:LMFA03010010
PGE2 Metabolite lipidmaps:LMFA03010003
PGF2a Metabolite lipidmaps:LMFA03010002
PGD2 Metabolite lipidmaps:LMFA03010004
PGJ2 Metabolite lipidmaps:LMFA03010019
delta-12-PGJ2 Metabolite lipidmaps:LMFA03010020
15-deoxy-delta-12-PGD2 Metabolite lipidmaps:LMFA03010021
11R-HETE Metabolite lipidmaps:LMFA03060028
PGI2 Metabolite lipidmaps:LMFA03010087
6-keto-PGF1alpha Metabolite lipidmaps:LMFA03010001
6-keto-PGE1 Metabolite lipidmaps:LMFA03010012
PGA2 Metabolite lipidmaps:LMFA03010035
15-deoxy-PGA2 Metabolite lipidmaps:LMFA03010172
Dinor-PGE2 Metabolite lipidmaps:LMFA03010210
Tetranor-PGE2 Metabolite lipidmaps:LMFA03010211
Dinor-PGF2a Metabolite lipidmaps:LMFA03010212
Tetranor-PGF2a Metabolite lipidmaps:LMFA03010213
Dinor-PGD2 Metabolite lipidmaps:LMFA03010214
Tetranor-PGD2 Metabolite lipidmaps:LMFA03010215
20-hydroxy-PGE2 Metabolite lipidmaps:LMFA03010014
20-hydroxy-PGF2a Metabolite lipidmaps:LMFA03010029
20-hydroxy-PGD2 Metabolite lipidmaps:LMFA03010216
15-deoxy-delta-12-PGJ2 Metabolite lipidmaps:LMFA03010021
TXA2 Metabolite lipidmaps:LMFA03030001
TXB2 Metabolite lipidmaps:LMFA03030002
11-dehydro-TXB2 Metabolite lipidmaps:LMFA03030004
12S-HHTrE Metabolite lipidmaps:LMFA03050002
15-keto-PGE2 Metabolite lipidmaps:LMFA03010030
15-keto-PGF2a Metabolite lipidmaps:LMFA03010026
15-keto-PGD2 Metabolite lipidmaps:LMFA03010022
13,14-dihydro-15-keto-PGE2 Metabolite lipidmaps:LMFA03010031
13,14-dihydro-15-keto-PGF2a Metabolite lipidmaps:LMFA03010027
13,14-dihydro-15-keto-PGD2 Metabolite lipidmaps:LMFA03010022
15(S)-HETE Metabolite lipidmaps:LMFA03060001
15(R)-HETE Metabolite lipidmaps:LMFA03060030
Ptgis GeneProduct ncbigene:19223
Tbxas1 GeneProduct ncbigene:21391
Hpgd GeneProduct ncbigene:15446
Pla2g5 Protein ncbigene:18784
PPAR delta Protein uniprot:P35396 AKA Peroxisome proliferator-activated receptor delta
Pla2g6 Protein ncbigene:53357
Pla2g4a Protein ncbigene:18783
Pla2g4b Protein ncbigene:211429
Ptgs1 Protein ncbigene:19224 AKA COX-1
Ptgs2 Protein ncbigene:19225 AKA COX-2
Ptges Protein ncbigene:64292
Ptgds Protein ncbigene:19215
Akr1b3 Protein ncbigene:11677
Ptgr1 Protein ncbigene:67103
Ptgr2 Protein ncbigene:77219
Cyp4a10 Protein ncbigene:13117
Cyp4a12a Protein ncbigene:277753
Cyp4a12b Protein ncbigene:13118
Cyp4f14 Protein ncbigene:64385
Cyp4f18 Protein ncbigene:72054
Acox1 Protein ncbigene:11430
Acox2 Protein ncbigene:93732
Acox3 Protein ncbigene:80911
Acaa1a Protein ncbigene:113868
Ehhadh Protein ncbigene:74147
IP Protein uniprot:P43252 AKA Prostacyclin receptor, prostaglandin I2 receptor or just IP [https://en.wikipedia.org/wiki/Prostacyclin_receptor]
PPAR gamma Protein uniprot:P37238 AKA Peroxisome proliferator-activated receptor gamma
PGFS Protein uniprot:Q9DB60 AKA Prxl2b
FP Protein uniprot:P43117 AKA Prostaglandin F receptor (FP) [https://en.wikipedia.org/wiki/Prostaglandin_F_receptor]
DP1 Protein uniprot:P70263 AKA Prostaglandin D2 receptor 1 (DP1) [https://en.wikipedia.org/wiki/Prostaglandin_DP1_receptor]
DP2 Protein uniprot:Q9Z2J6 AKA Prostaglandin D2 receptor 2 (DP2 or CRTH2) [https://en.wikipedia.org/wiki/Prostaglandin_DP2_receptor]
TP Protein uniprot:P30987 AKA thromboxane receptor (TP) also known as the prostanoid TP receptor [https://en.wikipedia.org/wiki/Thromboxane_receptor]
COX-1 Protein uniprot:P22437

References

  1. Metabolism of prostaglandins E, A, and C in serum. Polet H, Levine L. J Biol Chem. 1975 Jan 25;250(2):351–7. PubMed Europe PMC Scholia
  2. New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development. Moreno JJ. Biochem Pharmacol. 2009 Jan 1;77(1):1–10. PubMed Europe PMC Scholia
  3. A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
  4. Eicosanoid storm in infection and inflammation. Dennis EA, Norris PC. Nat Rev Immunol. 2015 Aug;15(8):511–23. PubMed Europe PMC Scholia