DNA IR-double strand breaks and cellular response via ATM (WP3959)

Homo sapiens

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Cited In

• Shared Genetic Risk Factors Between Cancer and Cardiovascular Diseases (2022).
• Investigating the Molecular Processes behind the Cell-Specific Toxicity Response to Titanium Dioxide Nanobelts (2021).
• Biological and clinical features of triple negative Invasive Lobular Carcinomas of the breast. Clinical outcome and actionable molecular alterations☆ (2021).
• The double dealing of cyclin D1 (2020).
• Autistic spectrum disorder (ASD) - Gene, molecular and pathway signatures linking systemic inflammation, mitochondrial dysfunction, transsynaptic signalling, and neurodevelopmen (2023).

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References

1. The production and repair of double strand breaks in cells from normal humans and from patients with ataxia telangiectasia. Lehman AR, Stevens S. Biochim Biophys Acta. 1977 Jan 3;474(1):49–60. PubMed Europe PMC Scholia
2. Group task functions. Harvey JS. Dent Assist (1931). 1975 Apr;44(4):25–6. PubMed Europe PMC Scholia
3. Evolution of DNA damage in irradiated cells. Hahnfeldt P, Sachs RK, Hlatky LR. J Math Biol. 1992;30(5):493–511. PubMed Europe PMC Scholia
4. DNA damage and repair. Ward JF. Basic Life Sci. 1991;58:403–15; discussion 415-21. PubMed Europe PMC Scholia
5. Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. Sadhu K, Reed SI, Richardson H, Russell P. Proc Natl Acad Sci U S A. 1990 Jul;87(13):5139–43. PubMed Europe PMC Scholia
6. The rejoining of double-strand breaks in DNA by human cell extracts. North P, Ganesh A, Thacker J. Nucleic Acids Res. 1990 Nov 11;18(21):6205–10. PubMed Europe PMC Scholia
7. DNA-break repair, radioresistance of DNA synthesis, and camptothecin sensitivity in the radiation-sensitive irs mutants: comparisons to ataxia-telangiectasia cells. Thacker J, Ganesh AN. Mutat Res. 1990 Mar;235(2):49–58. PubMed Europe PMC Scholia
8. Structure of the human gene for the proliferating cell nuclear antigen. Travali S, Ku DH, Rizzo MG, Ottavio L, Baserga R, Calabretta B. J Biol Chem. 1989 May 5;264(13):7466–72. PubMed Europe PMC Scholia
9. The initial physical damage produced by ionizing radiations. Goodhead DT. Int J Radiat Biol. 1989 Nov;56(5):623–34. PubMed Europe PMC Scholia
10. Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins. Almendral JM, Huebsch D, Blundell PA, Macdonald-Bravo H, Bravo R. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1575–9. PubMed Europe PMC Scholia
11. Characterization of the human p53 gene. Lamb P, Crawford L. Mol Cell Biol. 1986 May;6(5):1379–85. PubMed Europe PMC Scholia
12. Molecular basis for heterogeneity of the human p53 protein. Harris N, Brill E, Shohat O, Prokocimer M, Wolf D, Arai N, et al. Mol Cell Biol. 1986 Dec;6(12):4650–6. PubMed Europe PMC Scholia
13. Human lymphocytes exposed to low doses of ionizing radiations become refractory to high doses of radiation as well as to chemical mutagens that induce double-strand breaks in DNA. Wolff S, Afzal V, Wiencke JK, Olivieri G, Michaeli A. Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Jan;53(1):39–47. PubMed Europe PMC Scholia
14. Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. Zakut-Houri R, Bienz-Tadmor B, Givol D, Oren M. EMBO J. 1985 May;4(5):1251–5. PubMed Europe PMC Scholia
15. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Kerr JF, Wyllie AH, Currie AR. Br J Cancer. 1972 Aug;26(4):239–57. PubMed Europe PMC Scholia
16. Double-strand breaks in DNA caused by repair of damage due to ultraviolet light. Bradley MO. J Supramol Struct Cell Biochem. 1981;16(4):337–43. PubMed Europe PMC Scholia
17. DNA strand break and rejoining in cultured human fibroblasts exposed to fast neutrons or gamma rays. Van der Schans GP, Paterson MC, Cross WG. Int J Radiat Biol Relat Stud Phys Chem Med. 1983 Jul;44(1):75–85. PubMed Europe PMC Scholia
18. DNA damage induced in human diploid cells by decay of incorporated radionuclides. LeMotte PK, Little JB. Cancer Res. 1984 Apr;44(4):1337–42. PubMed Europe PMC Scholia
19. Normal repair of gamma radiation-induced single-strand and double-strand DNA breaks in retinoblastoma fibroblasts. Woods WG, Lopez M, Kalvonjian SL. Biochim Biophys Acta. 1982 Jul 30;698(1):40–8. PubMed Europe PMC Scholia
20. Cell cycle checkpoints and repair of ionizing radiation damage. Liu VF, Boubnov NV, Weaver DT. Stem Cells. 1995 May;13 Suppl 1:117–28. PubMed Europe PMC Scholia
21. Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination. Muris DF, Bezzubova O, Buerstedde JM, Vreeken K, Balajee AS, Osgood CJ, et al. Mutat Res. 1994 Nov;315(3):295–305. PubMed Europe PMC Scholia
22. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, et al. Science. 1994 Oct 7;266(5182):66–71. PubMed Europe PMC Scholia
23. The Bloom’s syndrome gene product is homologous to RecQ helicases. Ellis NA, Groden J, Ye TZ, Straughen J, Lennon DJ, Ciocci S, et al. Cell. 1995 Nov 17;83(4):655–66. PubMed Europe PMC Scholia
24. Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. Poltoratsky VP, Shi X, York JD, Lieber MR, Carter TH. J Immunol. 1995 Nov 15;155(10):4529–33. PubMed Europe PMC Scholia
25. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, et al. Nature. 1995 Jul 6;376(6535):37–43. PubMed Europe PMC Scholia
26. Cell cycle checkpoints and DNA repair preserve the stability of the human genome. Kaufmann WK. Cancer Metastasis Rev. 1995 Mar;14(1):31–41. PubMed Europe PMC Scholia
27. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, et al. Cell. 1995 Sep 8;82(5):849–56. PubMed Europe PMC Scholia
28. Induction of apoptosis by the Bcl-2 homologue Bak. Chittenden T, Harrington EA, O’Connor R, Flemington C, Lutz RJ, Evan GI, et al. Nature. 1995 Apr 20;374(6524):733–6. PubMed Europe PMC Scholia
29. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Kiefer MC, Brauer MJ, Powers VC, Wu JJ, Umansky SR, Tomei LD, et al. Nature. 1995 Apr 20;374(6524):736–9. PubMed Europe PMC Scholia
30. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Tewari M, Quan LT, O’Rourke K, Desnoyers S, Zeng Z, Beidler DR, et al. Cell. 1995 Jun 2;81(5):801–9. PubMed Europe PMC Scholia
31. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, et al. Science. 1995 Jun 23;268(5218):1749–53. PubMed Europe PMC Scholia
32. Phosphorylation of E2F-1 by cyclin A-cdk2. Kitagawa M, Higashi H, Suzuki-Takahashi I, Segawa K, Hanks SK, Taya Y, et al. Oncogene. 1995 Jan 19;10(2):229–36. PubMed Europe PMC Scholia
33. Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Goodhead DT. Int J Radiat Biol. 1994 Jan;65(1):7–17. PubMed Europe PMC Scholia
34. Transcriptional regulation of the PCNA promoter by p53. Jackson P, Ridgway P, Rayner J, Noble J, Braithwaite A. Biochem Biophys Res Commun. 1994 Aug 30;203(1):133–40. PubMed Europe PMC Scholia
35. BRCA1 mutations in primary breast and ovarian carcinomas. Futreal PA, Liu Q, Shattuck-Eidens D, Cochran C, Harshman K, Tavtigian S, et al. Science. 1994 Oct 7;266(5182):120–2. PubMed Europe PMC Scholia
36. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Johnson DG, Ohtani K, Nevins JR. Genes Dev. 1994 Jul 1;8(13):1514–25. PubMed Europe PMC Scholia
37. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H. Mol Cell Biol. 1994 Dec;14(12):8420–31. PubMed Europe PMC Scholia
38. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. Fernandes-Alnemri T, Litwack G, Alnemri ES. J Biol Chem. 1994 Dec 9;269(49):30761–4. PubMed Europe PMC Scholia
39. Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis. Strausfeld U, Fernandez A, Capony JP, Girard F, Lautredou N, Derancourt J, et al. J Biol Chem. 1994 Feb 25;269(8):5989–6000. PubMed Europe PMC Scholia
40. Dose-rate effect for DNA damage induced by ionizing radiation in human tumor cells. Ruiz de Almodóvar JM, Bush C, Peacock JH, Steel GG, Whitaker SJ, McMillan TJ. Radiat Res. 1994 Apr;138(1 Suppl):S93-6. PubMed Europe PMC Scholia
41. p53 and E2F-1 cooperate to mediate apoptosis. Wu X, Levine AJ. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3602–6. PubMed Europe PMC Scholia
42. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Khanna KK, Lavin MF. Oncogene. 1993 Dec;8(12):3307–12. PubMed Europe PMC Scholia
43. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Oltvai ZN, Milliman CL, Korsmeyer SJ. Cell. 1993 Aug 27;74(4):609–19. PubMed Europe PMC Scholia
44. The repair of ionising radiation-induced damage to DNA. Price A. Semin Cancer Biol. 1993 Apr;4(2):61–71. PubMed Europe PMC Scholia
45. Genomic organization of the ATM locus involved in ataxia-telangiectasia. Rasio D, Negrini M, Croce CM. Cancer Res. 1995 Dec 15;55(24):6053–7. PubMed Europe PMC Scholia
46. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. Chittenden T, Flemington C, Houghton AB, Ebb RG, Gallo GJ, Elangovan B, et al. EMBO J. 1995 Nov 15;14(22):5589–96. PubMed Europe PMC Scholia
47. Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Creasy CL, Chernoff J. Gene. 1995 Dec 29;167(1–2):303–6. PubMed Europe PMC Scholia
48. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Savitsky K, Sfez S, Tagle DA, Ziv Y, Sartiel A, Collins FS, et al. Hum Mol Genet. 1995 Nov;4(11):2025–32. PubMed Europe PMC Scholia
49. The human tumour suppressor gene p53 is alternatively spliced in normal cells. Flaman JM, Waridel F, Estreicher A, Vannier A, Limacher JM, Gilbert D, et al. Oncogene. 1996 Feb 15;12(4):813–8. PubMed Europe PMC Scholia
50. The ATM gene and susceptibility to breast cancer: analysis of 38 breast tumors reveals no evidence for mutation. Vorechovský I, Rasio D, Luo L, Monaco C, Hammarström L, Webster AD, et al. Cancer Res. 1996 Jun 15;56(12):2726–32. PubMed Europe PMC Scholia
51. KAP-1, a novel corepressor for the highly conserved KRAB repression domain. Friedman JR, Fredericks WJ, Jensen DE, Speicher DW, Huang XP, Neilson EG, et al. Genes Dev. 1996 Aug 15;10(16):2067–78. PubMed Europe PMC Scholia
52. TRAF6 is a signal transducer for interleukin-1. Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV. Nature. 1996 Oct 3;383(6599):443–6. PubMed Europe PMC Scholia
53. BID: a novel BH3 domain-only death agonist. Wang K, Yin XM, Chao DT, Milliman CL, Korsmeyer SJ. Genes Dev. 1996 Nov 15;10(22):2859–69. PubMed Europe PMC Scholia
54. Repression of human heat shock factor 1 activity at control temperature by phosphorylation. Knauf U, Newton EM, Kyriakis J, Kingston RE. Genes Dev. 1996 Nov 1;10(21):2782–93. PubMed Europe PMC Scholia
55. Structure and partial genomic sequence of the human E2F1 gene. Neuman E, Sellers WR, McNeil JA, Lawrence JB, Kaelin WG Jr. Gene. 1996 Sep 16;173(2):163–9. PubMed Europe PMC Scholia
56. The product of the ATM gene is a 370-kDa nuclear phosphoprotein. Chen G, Lee EYHP. J Biol Chem. 1996 Dec 27;271(52):33693–7. PubMed Europe PMC Scholia
57. Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Yuan ZM, Huang Y, Ishiko T, Kharbanda S, Weichselbaum R, Kufe D. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1437–40. PubMed Europe PMC Scholia
58. PCNA: structure, functions and interactions. Kelman Z. Oncogene. 1997 Feb 13;14(6):629–40. PubMed Europe PMC Scholia
59. Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone. Mittl PR, Di Marco S, Krebs JF, Bai X, Karanewsky DS, Priestle JP, et al. J Biol Chem. 1997 Mar 7;272(10):6539–47. PubMed Europe PMC Scholia
60. The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage. Brown KD, Ziv Y, Sadanandan SN, Chessa L, Collins FS, Shiloh Y, et al. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1840–5. PubMed Europe PMC Scholia
61. Intact G2-phase checkpoint in cells of a human cell line lacking DNA-dependent protein kinase activity. Allalunis-Turner J, Barron GM, Day RS 3rd. Radiat Res. 1997 Mar;147(3):284–7. PubMed Europe PMC Scholia
62. Functional interaction between DNA-PK and c-Abl in response to DNA damage. Kharbanda S, Pandey P, Jin S, Inoue S, Bharti A, Yuan ZM, et al. Nature. 1997 Apr 17;386(6626):732–5. PubMed Europe PMC Scholia
63. Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation. Kline MP, Morimoto RI. Mol Cell Biol. 1997 Apr;17(4):2107–15. PubMed Europe PMC Scholia
64. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Baskaran R, Wood LD, Whitaker LL, Canman CE, Morgan SE, Xu Y, et al. Nature. 1997 May 29;387(6632):516–9. PubMed Europe PMC Scholia
65. Ataxia-telangiectasia locus: sequence analysis of 184 kb of human genomic DNA containing the entire ATM gene. Platzer M, Rotman G, Bauer D, Uziel T, Savitsky K, Bar-Shira A, et al. Genome Res. 1997 Jun;7(6):592–605. PubMed Europe PMC Scholia
66. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Cell. 1997 Aug 8;90(3):405–13. PubMed Europe PMC Scholia
67. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, et al. Science. 1997 Sep 5;277(5331):1497–501. PubMed Europe PMC Scholia
68. Inhibition of phosphatidylinositol 3-kinase by c-Abl in the genotoxic stress response. Yuan ZM, Utsugisawa T, Huang Y, Ishiko T, Nakada S, Kharbanda S, et al. J Biol Chem. 1997 Sep 19;272(38):23485–8. PubMed Europe PMC Scholia
69. The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis. Rhéaume E, Cohen LY, Uhlmann F, Lazure C, Alam A, Hurwitz J, et al. EMBO J. 1997 Nov 3;16(21):6346–54. PubMed Europe PMC Scholia
70. Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress? Rotman G, Shiloh Y. Bioessays. 1997 Oct;19(10):911–7. PubMed Europe PMC Scholia
71. BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal. Kaneko H, Orii KO, Matsui E, Shimozawa N, Fukao T, Matsumoto T, et al. Biochem Biophys Res Commun. 1997 Nov 17;240(2):348–53. PubMed Europe PMC Scholia
72. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, et al. Cell. 1997 Nov 14;91(4):479–89. PubMed Europe PMC Scholia
73. DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. Hammarsten O, Chu G. Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):525–30. PubMed Europe PMC Scholia
74. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. Honda R, Tanaka H, Yasuda H. FEBS Lett. 1997 Dec 22;420(1):25–7. PubMed Europe PMC Scholia
75. TRF2 protects human telomeres from end-to-end fusions. van Steensel B, Smogorzewska A, de Lange T. Cell. 1998 Feb 6;92(3):401–13. PubMed Europe PMC Scholia
76. Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex. Pan G, O’Rourke K, Dixit VM. J Biol Chem. 1998 Mar 6;273(10):5841–5. PubMed Europe PMC Scholia
77. Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication. Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Ménissier-de Murcia J. Nucleic Acids Res. 1998 Apr 15;26(8):1891–8. PubMed Europe PMC Scholia
78. The 3’ to 5’ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Paull TT, Gellert M. Mol Cell. 1998 Jun;1(7):969–79. PubMed Europe PMC Scholia
79. Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Levkau B, Koyama H, Raines EW, Clurman BE, Herren B, Orth K, et al. Mol Cell. 1998 Mar;1(4):553–63. PubMed Europe PMC Scholia
80. DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D. Yavuzer U, Smith GC, Bliss T, Werner D, Jackson SP. Genes Dev. 1998 Jul 15;12(14):2188–99. PubMed Europe PMC Scholia
81. Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1. Wilson DM 3rd, Carney JP, Coleman MA, Adamson AW, Christensen M, Lamerdin JE. Nucleic Acids Res. 1998 Aug 15;26(16):3762–8. PubMed Europe PMC Scholia
82. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. Trujillo KM, Yuan SS, Lee EY, Sung P. J Biol Chem. 1998 Aug 21;273(34):21447–50. PubMed Europe PMC Scholia
83. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, et al. Science. 1998 Sep 11;281(5383):1674–7. PubMed Europe PMC Scholia
84. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. Science. 1998 Sep 11;281(5383):1677–9. PubMed Europe PMC Scholia
85. ATM: from gene to function. Rotman G, Shiloh Y. Hum Mol Genet. 1998;7(10):1555–63. PubMed Europe PMC Scholia
86. Proteolytic activation of PKN by caspase-3 or related protease during apoptosis. Takahashi M, Mukai H, Toshimori M, Miyamoto M, Ono Y. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11566–71. PubMed Europe PMC Scholia
87. Two new p73 splice variants, gamma and delta, with different transcriptional activity. De Laurenzi V, Costanzo A, Barcaroli D, Terrinoni A, Falco M, Annicchiarico-Petruzzelli M, et al. J Exp Med. 1998 Nov 2;188(9):1763–8. PubMed Europe PMC Scholia
88. Regulation of cell death protease caspase-9 by phosphorylation. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, et al. Science. 1998 Nov 13;282(5392):1318–21. PubMed Europe PMC Scholia
89. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Matsuoka S, Huang M, Elledge SJ. Science. 1998 Dec 4;282(5395):1893–7. PubMed Europe PMC Scholia
90. ATM associates with and phosphorylates p53: mapping the region of interaction. Khanna KK, Keating KE, Kozlov S, Scott S, Gatei M, Hobson K, et al. Nat Genet. 1998 Dec;20(4):398–400. PubMed Europe PMC Scholia
91. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Blasina A, de Weyer IV, Laus MC, Luyten WH, Parker AE, McGowan CH. Curr Biol. 1999 Jan 14;9(1):1–10. PubMed Europe PMC Scholia
92. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, et al. J Cell Biol. 1999 Jan 25;144(2):281–92. PubMed Europe PMC Scholia
93. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Brown AL, Lee CH, Schwarz JK, Mitiku N, Piwnica-Worms H, Chung JH. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3745–50. PubMed Europe PMC Scholia
94. The emerging p53 gene family. Kaelin WG Jr. J Natl Cancer Inst. 1999 Apr 7;91(7):594–8. PubMed Europe PMC Scholia
95. An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. Zou H, Li Y, Liu X, Wang X. J Biol Chem. 1999 Apr 23;274(17):11549–56. PubMed Europe PMC Scholia
96. hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation. Li L, Peterson CA, Kanter-Smoler G, Wei YF, Ramagli LS, Sunnerhagen P, et al. Oncogene. 1999 Mar 4;18(9):1689–99. PubMed Europe PMC Scholia
97. Conformation of the Bax C-terminus regulates subcellular location and cell death. Nechushtan A, Smith CL, Hsu YT, Youle RJ. EMBO J. 1999 May 4;18(9):2330–41. PubMed Europe PMC Scholia
98. Mutational analysis of p73 and p53 in human cancer cell lines. Yoshikawa H, Nagashima M, Khan MA, McMenamin MG, Hagiwara K, Harris CC. Oncogene. 1999 Jun 3;18(22):3415–21. PubMed Europe PMC Scholia
99. Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance. Qiu J, Qian Y, Chen V, Guan MX, Shen B. J Biol Chem. 1999 Jun 18;274(25):17893–900. PubMed Europe PMC Scholia
100. Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. Saleh A, Srinivasula SM, Acharya S, Fishel R, Alnemri ES. J Biol Chem. 1999 Jun 18;274(25):17941–5. PubMed Europe PMC Scholia
101. Human Rad51 amino acid residues required for Rad52 binding. Kurumizaka H, Aihara H, Kagawa W, Shibata T, Yokoyama S. J Mol Biol. 1999 Aug 20;291(3):537–48. PubMed Europe PMC Scholia
102. Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation. Suzuki K, Kodama S, Watanabe M. J Biol Chem. 1999 Sep 3;274(36):25571–5. PubMed Europe PMC Scholia
103. NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. Allard S, Utley RT, Savard J, Clarke A, Grant P, Brandl CJ, et al. EMBO J. 1999 Sep 15;18(18):5108–19. PubMed Europe PMC Scholia
104. Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis. Swanton E, Bishop N, Woodman P. J Biol Chem. 1999 Dec 31;274(53):37583–90. PubMed Europe PMC Scholia
105. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Khosravi R, Maya R, Gottlieb T, Oren M, Shiloh Y, Shkedy D. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14973–7. PubMed Europe PMC Scholia
106. Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis. Bushell M, Wood W, Clemens MJ, Morley SJ. Eur J Biochem. 2000 Feb;267(4):1083–91. PubMed Europe PMC Scholia
107. Identification of novel isoforms of human RAD52. Kito K, Wada H, Yeh ET, Kamitani T. Biochim Biophys Acta. 1999 Dec 23;1489(2–3):303–14. PubMed Europe PMC Scholia
108. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. Graves PR, Yu L, Schwarz JK, Gales J, Sausville EA, O’Connor PM, et al. J Biol Chem. 2000 Feb 25;275(8):5600–5. PubMed Europe PMC Scholia
109. Human DNA damage checkpoint protein hRAD9 is a 3’ to 5’ exonuclease. Bessho T, Sancar A. J Biol Chem. 2000 Mar 17;275(11):7451–4. PubMed Europe PMC Scholia
110. Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex. Weber JD, Kuo ML, Bothner B, DiGiammarino EL, Kriwacki RW, Roussel MF, et al. Mol Cell Biol. 2000 Apr;20(7):2517–28. PubMed Europe PMC Scholia
111. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. J Biol Chem. 2000 Mar 24;275(12):8945–51. PubMed Europe PMC Scholia
112. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Lee JS, Collins KM, Brown AL, Lee CH, Chung JH. Nature. 2000 Mar 9;404(6774):201–4. PubMed Europe PMC Scholia
113. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, et al. Genes Dev. 2000 Jun 15;14(12):1448–59. PubMed Europe PMC Scholia
114. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Zhu XD, Küster B, Mann M, Petrini JH, de Lange T. Nat Genet. 2000 Jul;25(3):347–52. PubMed Europe PMC Scholia
115. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, et al. Genes Dev. 2000 Aug 15;14(16):2060–71. PubMed Europe PMC Scholia
116. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10389–94. PubMed Europe PMC Scholia
117. Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. Bhattacharya A, Czaplinski K, Trifillis P, He F, Jacobson A, Peltz SW. RNA. 2000 Sep;6(9):1226–35. PubMed Europe PMC Scholia
118. Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis. Affar EB, Germain M, Winstall E, Vodenicharov M, Shah RG, Salvesen GS, et al. J Biol Chem. 2001 Jan 26;276(4):2935–42. PubMed Europe PMC Scholia
119. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Deng L, Wang C, Spencer E, Yang L, Braun A, You J, et al. Cell. 2000 Oct 13;103(2):351–61. PubMed Europe PMC Scholia
120. Characterization of vertebrate cohesin complexes and their regulation in prophase. Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM. J Cell Biol. 2000 Nov 13;151(4):749–62. PubMed Europe PMC Scholia
121. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Kumagai A, Dunphy WG. Mol Cell. 2000 Oct;6(4):839–49. PubMed Europe PMC Scholia
122. Structure of Bax: coregulation of dimer formation and intracellular localization. Suzuki M, Youle RJ, Tjandra N. Cell. 2000 Nov 10;103(4):645–54. PubMed Europe PMC Scholia
123. Regulation of cell death by the Abl tyrosine kinase. Wang JY. Oncogene. 2000 Nov 20;19(49):5643–50. PubMed Europe PMC Scholia
124. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Lykke-Andersen J, Shu MD, Steitz JA. Cell. 2000 Dec 22;103(7):1121–31. PubMed Europe PMC Scholia
125. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, et al. Mol Cell. 2001 Feb;7(2):249–62. PubMed Europe PMC Scholia
126. The many substrates and functions of ATM. Kastan MB, Lim DS. Nat Rev Mol Cell Biol. 2000 Dec;1(3):179–86. PubMed Europe PMC Scholia
127. ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation. Chen MJ, Lin YT, Lieberman HB, Chen G, Lee EY. J Biol Chem. 2001 May 11;276(19):16580–6. PubMed Europe PMC Scholia
128. Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. Gatei M, Zhou BB, Hobson K, Scott S, Young D, Khanna KK. J Biol Chem. 2001 May 18;276(20):17276–80. PubMed Europe PMC Scholia
129. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Falck J, Mailand N, Syljuåsen RG, Bartek J, Lukas J. Nature. 2001 Apr 12;410(6830):842–7. PubMed Europe PMC Scholia
130. Human ARF protein interacts with topoisomerase I and stimulates its activity. Karayan L, Riou JF, Séité P, Migeon J, Cantereau A, Larsen CJ. Oncogene. 2001 Feb 15;20(7):836–48. PubMed Europe PMC Scholia
131. Human ARF binds E2F1 and inhibits its transcriptional activity. Eymin B, Karayan L, Séité P, Brambilla C, Brambilla E, Larsen CJ, et al. Oncogene. 2001 Mar 1;20(9):1033–41. PubMed Europe PMC Scholia
132. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. Rappold I, Iwabuchi K, Date T, Chen J. J Cell Biol. 2001 Apr 30;153(3):613–20. PubMed Europe PMC Scholia
133. ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Maya R, Balass M, Kim ST, Shkedy D, Leal JF, Shifman O, et al. Genes Dev. 2001 May 1;15(9):1067–77. PubMed Europe PMC Scholia
134. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. Burbee DG, Forgacs E, Zöchbauer-Müller S, Shivakumar L, Fong K, Gao B, et al. J Natl Cancer Inst. 2001 May 2;93(9):691–9. PubMed Europe PMC Scholia
135. Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Moshous D, Callebaut I, de Chasseval R, Corneo B, Cavazzana-Calvo M, Le Deist F, et al. Cell. 2001 Apr 20;105(2):177–86. PubMed Europe PMC Scholia
136. Apaf-1 is a transcriptional target for E2F and p53. Moroni MC, Hickman ES, Lazzerini Denchi E, Caprara G, Colli E, Cecconi F, et al. Nat Cell Biol. 2001 Jun;3(6):552–8. PubMed Europe PMC Scholia
137. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Zhao H, Piwnica-Worms H. Mol Cell Biol. 2001 Jul;21(13):4129–39. PubMed Europe PMC Scholia
138. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, et al. Nature. 2001 Jun 21;411(6840):969–74. PubMed Europe PMC Scholia
139. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A, et al. EMBO J. 2001 Jul 16;20(14):3800–10. PubMed Europe PMC Scholia
140. Nuclear retention of ATM at sites of DNA double strand breaks. Andegeko Y, Moyal L, Mittelman L, Tsarfaty I, Shiloh Y, Rotman G. J Biol Chem. 2001 Oct 12;276(41):38224–30. PubMed Europe PMC Scholia
141. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Lin WC, Lin FT, Nevins JR. Genes Dev. 2001 Jul 15;15(14):1833–44. PubMed Europe PMC Scholia
142. DNA structures and radiation injury. Erzgräber G, Rosemann M, Regel K, Abel H. Adv Space Res. 1992;12(2–3):91–101. PubMed Europe PMC Scholia
143. The influence of radiation quality on the formation of DNA breaks. Roots R, Holley W, Chatterjee A, Rachal E, Kraft G. Adv Space Res. 1989;9(10):45–55. PubMed Europe PMC Scholia
144. Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex. Bratton SB, Walker G, Roberts DL, Cain K, Cohen GM. Cell Death Differ. 2001 Apr;8(4):425–33. PubMed Europe PMC Scholia
145. Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. Guo Y, Guettouche T, Fenna M, Boellmann F, Pratt WB, Toft DO, et al. J Biol Chem. 2001 Dec 7;276(49):45791–9. PubMed Europe PMC Scholia
146. Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex. Nourani A, Doyon Y, Utley RT, Allard S, Lane WS, Côté J. Mol Cell Biol. 2001 Nov;21(22):7629–40. PubMed Europe PMC Scholia
147. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. Post S, Weng YC, Cimprich K, Chen LB, Xu Y, Lee EY. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13102–7. PubMed Europe PMC Scholia
148. Mechanisms of p53-dependent apoptosis. Schuler M, Green DR. Biochem Soc Trans. 2001 Nov;29(Pt 6):684–8. PubMed Europe PMC Scholia
149. Human Rad50/Mre11 is a flexible complex that can tether DNA ends. de Jager M, van Noort J, van Gent DC, Dekker C, Kanaar R, Wyman C. Mol Cell. 2001 Nov;8(5):1129–35. PubMed Europe PMC Scholia
150. Human exonuclease I is required for 5’ and 3’ mismatch repair. Genschel J, Bazemore LR, Modrich P. J Biol Chem. 2002 Apr 12;277(15):13302–11. PubMed Europe PMC Scholia
151. Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. O’Neill T, Giarratani L, Chen P, Iyer L, Lee CH, Bobiak M, et al. J Biol Chem. 2002 May 3;277(18):16102–15. PubMed Europe PMC Scholia
152. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC. Nat Genet. 2002 Mar;30(3):285–9. PubMed Europe PMC Scholia
153. Molecular interactions of human Exo1 with DNA. Lee Bi B in, Nguyen LH, Barsky D, Fernandes M, Wilson DM 3rd. Nucleic Acids Res. 2002 Feb 15;30(4):942–9. PubMed Europe PMC Scholia
154. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Acehan D, Jiang X, Morgan DG, Heuser JE, Wang X, Akey CW. Mol Cell. 2002 Feb;9(2):423–32. PubMed Europe PMC Scholia
155. Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Kim ST, Xu B, Kastan MB. Genes Dev. 2002 Mar 1;16(5):560–70. PubMed Europe PMC Scholia
156. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Yazdi PT, Wang Y, Zhao S, Patel N, Lee EYHP, Qin J. Genes Dev. 2002 Mar 1;16(5):571–82. PubMed Europe PMC Scholia
157. Bloom’s syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. Franchitto A, Pichierri P. J Cell Biol. 2002 Apr 1;157(1):19–30. PubMed Europe PMC Scholia
158. Mechanisms of caspase activation and inhibition during apoptosis. Shi Y. Mol Cell. 2002 Mar;9(3):459–70. PubMed Europe PMC Scholia
159. The human p73 promoter: characterization and identification of functional E2F binding sites. Seelan RS, Irwin M, van der Stoop P, Qian C, Kaelin WG Jr, Liu W. Neoplasia. 2002;4(3):195–203. PubMed Europe PMC Scholia
160. The BLM helicase is necessary for normal DNA double-strand break repair. Langland G, Elliott J, Li Y, Creaney J, Dixon K, Groden J. Cancer Res. 2002 May 15;62(10):2766–70. PubMed Europe PMC Scholia
161. The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation. Shivakumar L, Minna J, Sakamaki T, Pestell R, White MA. Mol Cell Biol. 2002 Jun;22(12):4309–18. PubMed Europe PMC Scholia
162. Identification of microcephalin, a protein implicated in determining the size of the human brain. Jackson AP, Eastwood H, Bell SM, Adu J, Toomes C, Carr IM, et al. Am J Hum Genet. 2002 Jul;71(1):136–42. PubMed Europe PMC Scholia
163. Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim ST, et al. Cell. 2002 May 17;109(4):459–72. PubMed Europe PMC Scholia
164. Distinct molecular mechanism for initiating TRAF6 signalling. Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, et al. Nature. 2002 Jul 25;418(6896):443–7. PubMed Europe PMC Scholia
165. Apaf-1 is a mediator of E2F-1-induced apoptosis. Furukawa Y, Nishimura N, Furukawa Y, Satoh M, Endo H, Iwase S, et al. J Biol Chem. 2002 Oct 18;277(42):39760–8. PubMed Europe PMC Scholia
166. Hypophosphorylation of Mdm2 augments p53 stability. Blattner C, Hay T, Meek DW, Lane DP. Mol Cell Biol. 2002 Sep;22(17):6170–82. PubMed Europe PMC Scholia
167. Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form. Kagawa W, Kurumizaka H, Ishitani R, Fukai S, Nureki O, Shibata T, et al. Mol Cell. 2002 Aug;10(2):359–71. PubMed Europe PMC Scholia
168. Localization of human SMC1 protein at kinetochores. Gregson HC, Van Hooser AA, Ball AR Jr, Brinkley BR, Yokomori K. Chromosome Res. 2002;10(4):267–77. PubMed Europe PMC Scholia
169. Homologous DNA pairing by human recombination factors Rad51 and Rad54. Sigurdsson S, Van Komen S, Petukhova G, Sung P. J Biol Chem. 2002 Nov 8;277(45):42790–4. PubMed Europe PMC Scholia
170. The roles of Bid. Esposti MD. Apoptosis. 2002 Oct;7(5):433–40. PubMed Europe PMC Scholia
171. Characterization of common BRCA1 and BRCA2 variants. Deffenbaugh AM, Frank TS, Hoffman M, Cannon-Albright L, Neuhausen SL. Genet Test. 2002;6(2):119–21. PubMed Europe PMC Scholia
172. S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Taniguchi T, Garcia-Higuera I, Andreassen PR, Gregory RC, Grompe M, D’Andrea AD. Blood. 2002 Oct 1;100(7):2414–20. PubMed Europe PMC Scholia
173. 53BP1, a mediator of the DNA damage checkpoint. Wang B, Matsuoka S, Carpenter PB, Elledge SJ. Science. 2002 Nov 15;298(5597):1435–8. PubMed Europe PMC Scholia
174. Structure of the single-strand annealing domain of human RAD52 protein. Singleton MR, Wentzell LM, Liu Y, West SC, Wigley DB. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13492–7. PubMed Europe PMC Scholia
175. Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation. Kitao H, Yuan ZM. J Biol Chem. 2002 Dec 13;277(50):48944–8. PubMed Europe PMC Scholia
176. DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP. de Jager M, Wyman C, van Gent DC, Kanaar R. Nucleic Acids Res. 2002 Oct 15;30(20):4425–31. PubMed Europe PMC Scholia
177. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. DiTullio RA Jr, Mochan TA, Venere M, Bartkova J, Sehested M, Bartek J, et al. Nat Cell Biol. 2002 Dec;4(12):998–1002. PubMed Europe PMC Scholia
178. Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways. Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne MC, et al. Mol Cancer Res. 2003 Jan;1(3):195–206. PubMed Europe PMC Scholia
179. Caspase 3 in breast cancer. O’Donovan N, Crown J, Stunell H, Hill ADK, McDermott E, O’Higgins N, et al. Clin Cancer Res. 2003 Feb;9(2):738–42. PubMed Europe PMC Scholia
180. MDC1 is required for the intra-S-phase DNA damage checkpoint. Goldberg M, Stucki M, Falck J, D’Amours D, Rahman D, Pappin D, et al. Nature. 2003 Feb 27;421(6926):952–6. PubMed Europe PMC Scholia
181. MDC1 is a mediator of the mammalian DNA damage checkpoint. Stewart GS, Wang B, Bignell CR, Taylor AMR, Elledge SJ. Nature. 2003 Feb 27;421(6926):961–6. PubMed Europe PMC Scholia
182. ATM and related protein kinases: safeguarding genome integrity. Shiloh Y. Nat Rev Cancer. 2003 Mar;3(3):155–68. PubMed Europe PMC Scholia
183. Interactive pathway of ARF-mdm2-p53. Lin J, Zhu MH. Ai Zheng. 2003 Mar;22(3):328–30. PubMed Europe PMC Scholia
184. Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, et al. Cancer Cell. 2003 Mar;3(3):247–58. PubMed Europe PMC Scholia
185. Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, et al. J Biol Chem. 2003 Jun 13;278(24):21767–73. PubMed Europe PMC Scholia
186. Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. Ward IM, Minn K, Jorda KG, Chen J. J Biol Chem. 2003 May 30;278(22):19579–82. PubMed Europe PMC Scholia
187. Chk2 activates E2F-1 in response to DNA damage. Stevens C, Smith L, La Thangue NB. Nat Cell Biol. 2003 May;5(5):401–9. PubMed Europe PMC Scholia
188. WRN interacts physically and functionally with the recombination mediator protein RAD52. Baynton K, Otterlei M, Bjørås M, von Kobbe C, Bohr VA, Seeberg E. J Biol Chem. 2003 Sep 19;278(38):36476–86. PubMed Europe PMC Scholia
189. Human claspin is required for replication checkpoint control. Chini CCS, Chen J. J Biol Chem. 2003 Aug 8;278(32):30057–62. PubMed Europe PMC Scholia
190. A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. Foray N, Marot D, Gabriel A, Randrianarison V, Carr AM, Perricaudet M, et al. EMBO J. 2003 Jun 2;22(11):2860–71. PubMed Europe PMC Scholia
191. Chk1 and Chk2 kinases in checkpoint control and cancer. Bartek J, Lukas J. Cancer Cell. 2003 May;3(5):421–9. PubMed Europe PMC Scholia
192. Apoptosis triggered redistribution of caspase-9 from cytoplasm to mitochondria. Potokar M, Milisav I, Kreft M, Stenovec M, Zorec R. FEBS Lett. 2003 Jun 5;544(1–3):153–9. PubMed Europe PMC Scholia
193. The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Vermeulen K, Van Bockstaele DR, Berneman ZN. Cell Prolif. 2003 Jun;36(3):131–49. PubMed Europe PMC Scholia
194. Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. Iwabuchi K, Basu BP, Kysela B, Kurihara T, Shibata M, Guan D, et al. J Biol Chem. 2003 Sep 19;278(38):36487–95. PubMed Europe PMC Scholia
195. Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells. Turowski P, Franckhauser C, Morris MC, Vaglio P, Fernandez A, Lamb NJC. Mol Biol Cell. 2003 Jul;14(7):2984–98. PubMed Europe PMC Scholia
196. Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Lee JH, Xu B, Lee CH, Ahn JY, Song MS, Lee H, et al. Mol Cancer Res. 2003 Jul;1(9):674–81. PubMed Europe PMC Scholia
197. Rad52 gene mutations in breast/ovarian cancer families and sporadic ovarian carcinoma patients. Tong D, Volm T, Eberhardt E, Krainer M, Leodolter S, Kreienberg R, et al. Oncol Rep. 2003;10(5):1551–3. PubMed Europe PMC Scholia
198. ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses. Yang J, Yu Y, Hamrick HE, Duerksen-Hughes PJ. Carcinogenesis. 2003 Oct;24(10):1571–80. PubMed Europe PMC Scholia
199. Focusing on foci: H2AX and the recruitment of DNA-damage response factors. Fernandez-Capetillo O, Celeste A, Nussenzweig A. Cell Cycle. 2003;2(5):426–7. PubMed Europe PMC Scholia
200. The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. Post SM, Tomkinson AE, Lee EYHP. Nucleic Acids Res. 2003 Oct 1;31(19):5568–75. PubMed Europe PMC Scholia
201. Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. Chen MS, Ryan CE, Piwnica-Worms H. Mol Cell Biol. 2003 Nov;23(21):7488–97. PubMed Europe PMC Scholia
202. Ways of dying: multiple pathways to apoptosis. Adams JM. Genes Dev. 2003 Oct 15;17(20):2481–95. PubMed Europe PMC Scholia
203. Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer. Vilenchik MM, Knudson AG. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12871–6. PubMed Europe PMC Scholia
204. Three novel Bid proteins generated by alternative splicing of the human Bid gene. Renshaw SA, Dempsey CE, Barnes FA, Bagstaff SM, Dower SK, Bingle CD, et al. J Biol Chem. 2004 Jan 23;279(4):2846–55. PubMed Europe PMC Scholia
205. The Bcl-2 family: roles in cell survival and oncogenesis. Cory S, Huang DCS, Adams JM. Oncogene. 2003 Nov 24;22(53):8590–607. PubMed Europe PMC Scholia
206. Mechanism of 5’-directed excision in human mismatch repair. Genschel J, Modrich P. Mol Cell. 2003 Nov;12(5):1077–86. PubMed Europe PMC Scholia
207. Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Itahana K, Bhat KP, Jin A, Itahana Y, Hawke D, Kobayashi R, et al. Mol Cell. 2003 Nov;12(5):1151–64. PubMed Europe PMC Scholia
208. Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA. Nielsen FC, Jäger AC, Lützen A, Bundgaard JR, Rasmussen LJ. Oncogene. 2004 Feb 19;23(7):1457–68. PubMed Europe PMC Scholia
209. 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Mochan TA, Venere M, DiTullio RA Jr, Halazonetis TD. Cancer Res. 2003 Dec 15;63(24):8586–91. PubMed Europe PMC Scholia
210. DNA-PKcs function regulated specifically by protein phosphatase 5. Wechsler T, Chen BPC, Harper R, Morotomi-Yano K, Huang BCB, Meek K, et al. Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1247–52. PubMed Europe PMC Scholia
211. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Song MS, Song SJ, Ayad NG, Chang JS, Lee JH, Hong HK, et al. Nat Cell Biol. 2004 Feb;6(2):129–37. PubMed Europe PMC Scholia
212. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Doyon Y, Selleck W, Lane WS, Tan S, Côté J. Mol Cell Biol. 2004 Mar;24(5):1884–96. PubMed Europe PMC Scholia
213. The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. Pichierri P, Rosselli F. EMBO J. 2004 Mar 10;23(5):1178–87. PubMed Europe PMC Scholia
214. Caspase 3 activation is controlled by a sequence located in the N-terminus of its large subunit. Pelletier M, Cartron PF, Delaval F, Meflah K, Vallette FM, Oliver L. Biochem Biophys Res Commun. 2004 Mar 26;316(1):93–9. PubMed Europe PMC Scholia
215. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Lee JH, Paull TT. Science. 2004 Apr 2;304(5667):93–6. PubMed Europe PMC Scholia
216. Functional and biochemical dissection of the structure-specific nuclease ARTEMIS. Pannicke U, Ma Y, Hopfner KP, Niewolik D, Lieber MR, Schwarz K. EMBO J. 2004 May 5;23(9):1987–97. PubMed Europe PMC Scholia
217. Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, et al. Hum Mol Genet. 2004 Jun 15;13(12):1241–8. PubMed Europe PMC Scholia
218. Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. Iida SI, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, et al. Oncogene. 2004 Jul 8;23(31):5266–74. PubMed Europe PMC Scholia
219. The highly conserved and multifunctional NuA4 HAT complex. Doyon Y, Côté J. Curr Opin Genet Dev. 2004 Apr;14(2):147–54. PubMed Europe PMC Scholia
220. Mutations in microcephalin cause aberrant regulation of chromosome condensation. Trimborn M, Bell SM, Felix C, Rashid Y, Jafri H, Griffiths PD, et al. Am J Hum Genet. 2004 Aug;75(2):261–6. PubMed Europe PMC Scholia
221. Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, et al. EMBO J. 2004 Jul 7;23(13):2674–83. PubMed Europe PMC Scholia
222. Apoptosis and disease: a life or death decision. MacFarlane M, Williams AC. EMBO Rep. 2004 Jul;5(7):674–8. PubMed Europe PMC Scholia
223. Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. Xu X, Lee J, Stern DF. J Biol Chem. 2004 Aug 13;279(33):34091–4. PubMed Europe PMC Scholia
224. LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. Yang X, Yu K, Hao Y, Li D ming, Stewart R, Insogna KL, et al. Nat Cell Biol. 2004 Jul;6(7):609–17. PubMed Europe PMC Scholia
225. Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation. Garg R, Callens S, Lim DS, Canman CE, Kastan MB, Xu B. Mol Cancer Res. 2004 Jun;2(6):362–9. PubMed Europe PMC Scholia
226. Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism. Uto K, Inoue D, Shimuta K, Nakajo N, Sagata N. EMBO J. 2004 Aug 18;23(16):3386–96. PubMed Europe PMC Scholia
227. Chk1 in the DNA damage response: conserved roles from yeasts to mammals. Chen Y, Sanchez Y. DNA Repair (Amst). 2004;3(8–9):1025–32. PubMed Europe PMC Scholia
228. The Chk2 protein kinase. Ahn J, Urist M, Prives C. DNA Repair (Amst). 2004;3(8–9):1039–47. PubMed Europe PMC Scholia
229. Role of the histone acetyl transferase Tip60 in the p53 pathway. Legube G, Linares LK, Tyteca S, Caron C, Scheffner M, Chevillard-Briet M, et al. J Biol Chem. 2004 Oct 22;279(43):44825–33. PubMed Europe PMC Scholia
230. ATR couples FANCD2 monoubiquitination to the DNA-damage response. Andreassen PR, D’Andrea AD, Taniguchi T. Genes Dev. 2004 Aug 15;18(16):1958–63. PubMed Europe PMC Scholia
231. Genomic organisation of the human MDM2 oncogene and relationship to its alternatively spliced mRNAs. Liang H, Atkins H, Abdel-Fattah R, Jones SN, Lunec J. Gene. 2004 Sep 1;338(2):217–23. PubMed Europe PMC Scholia
232. Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Silverman J, Takai H, Buonomo SBC, Eisenhaber F, de Lange T. Genes Dev. 2004 Sep 1;18(17):2108–19. PubMed Europe PMC Scholia
233. Human Arf tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes. Ayrault O, Andrique L, Larsen CJ, Seite P. Oncogene. 2004 Oct 21;23(49):8097–104. PubMed Europe PMC Scholia
234. Negative regulation of p53 functions by Daxx and the involvement of MDM2. Zhao LY, Liu J, Sidhu GS, Niu Y, Liu Y, Wang R, et al. J Biol Chem. 2004 Nov 26;279(48):50566–79. PubMed Europe PMC Scholia
235. MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. Lou Z, Chen BPC, Asaithamby A, Minter-Dykhouse K, Chen DJ, Chen J. J Biol Chem. 2004 Nov 5;279(45):46359–62. PubMed Europe PMC Scholia
236. A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint. Freie BW, Ciccone SLM, Li X, Plett PA, Orschell CM, Srour EF, et al. J Biol Chem. 2004 Dec 3;279(49):50986–93. PubMed Europe PMC Scholia
237. Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin. Montes de Oca R, Andreassen PR, Margossian SP, Gregory RC, Taniguchi T, Wang X, et al. Blood. 2005 Feb 1;105(3):1003–9. PubMed Europe PMC Scholia
238. Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Zhang X, Succi J, Feng Z, Prithivirajsingh S, Story MD, Legerski RJ. Mol Cell Biol. 2004 Oct;24(20):9207–20. PubMed Europe PMC Scholia
239. Phosphorylation of Artemis following irradiation-induced DNA damage. Poinsignon C, de Chasseval R, Soubeyrand S, Moshous D, Fischer A, Haché RJG, et al. Eur J Immunol. 2004 Nov;34(11):3146–55. PubMed Europe PMC Scholia
240. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. Tsao CC, Geisen C, Abraham RT. EMBO J. 2004 Nov 24;23(23):4660–9. PubMed Europe PMC Scholia
241. The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression. Suzuki H, Kurita M, Mizumoto K, Moriyama M, Aiso S, Nishimoto I, et al. Biochem Biophys Res Commun. 2005 Jan 7;326(1):242–8. PubMed Europe PMC Scholia
242. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Riballo E, Kühne M, Rief N, Doherty A, Smith GCM, Recio MJ, et al. Mol Cell. 2004 Dec 3;16(5):715–24. PubMed Europe PMC Scholia
243. The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA. Cartron PF, Gallenne T, Bougras G, Gautier F, Manero F, Vusio P, et al. Mol Cell. 2004 Dec 3;16(5):807–18. PubMed Europe PMC Scholia
244. Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. Xu L, Blackburn EH. J Cell Biol. 2004 Dec 6;167(5):819–30. PubMed Europe PMC Scholia
245. Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. O’Neill E, Rushworth L, Baccarini M, Kolch W. Science. 2004 Dec 24;306(5705):2267–70. PubMed Europe PMC Scholia
246. SMC1 involvement in fragile site expression. Musio A, Montagna C, Mariani T, Tilenni M, Focarelli ML, Brait L, et al. Hum Mol Genet. 2005 Feb 15;14(4):525–33. PubMed Europe PMC Scholia
247. DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint. Huang X, Tran T, Zhang L, Hatcher R, Zhang P. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1065–70. PubMed Europe PMC Scholia
248. Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Nakanishi K, Yang YG, Pierce AJ, Taniguchi T, Digweed M, D’Andrea AD, et al. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1110–5. PubMed Europe PMC Scholia
249. p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation. Ou YH, Chung PH, Sun TP, Shieh SY. Mol Biol Cell. 2005 Apr;16(4):1684–95. PubMed Europe PMC Scholia
250. Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. Ohashi A, Zdzienicka MZ, Chen J, Couch FJ. J Biol Chem. 2005 Apr 15;280(15):14877–83. PubMed Europe PMC Scholia
251. Role of c-Abl in the DNA damage stress response. Shaul Y, Ben-Yehoyada M. Cell Res. 2005 Jan;15(1):33–5. PubMed Europe PMC Scholia
252. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Chan EHY, Nousiainen M, Chalamalasetty RB, Schäfer A, Nigg EA, Silljé HHW. Oncogene. 2005 Mar 17;24(12):2076–86. PubMed Europe PMC Scholia
253. Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination. Restle A, Janz C, Wiesmüller L. Oncogene. 2005 Jun 23;24(27):4380–7. PubMed Europe PMC Scholia
254. Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. Wang J, Pluth JM, Cooper PK, Cowan MJ, Chen DJ, Yannone SM. DNA Repair (Amst). 2005 May 2;4(5):556–70. PubMed Europe PMC Scholia
255. The p53 pathway: positive and negative feedback loops. Harris SL, Levine AJ. Oncogene. 2005 Apr 18;24(17):2899–908. PubMed Europe PMC Scholia
256. ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Bhoumik A, Takahashi S, Breitweiser W, Shiloh Y, Jones N, Ronai Z. Mol Cell. 2005 May 27;18(5):577–87. PubMed Europe PMC Scholia
257. The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps. Ma Y, Schwarz K, Lieber MR. DNA Repair (Amst). 2005 Jul 12;4(7):845–51. PubMed Europe PMC Scholia
258. The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death. Baksh S, Tommasi S, Fenton S, Yu VC, Martins LM, Pfeifer GP, et al. Mol Cell. 2005 Jun 10;18(6):637–50. PubMed Europe PMC Scholia
259. ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Chen D, Kon N, Li M, Zhang W, Qin J, Gu W. Cell. 2005 Jul 1;121(7):1071–83. PubMed Europe PMC Scholia
260. Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. Bekker-Jensen S, Lukas C, Melander F, Bartek J, Lukas J. J Cell Biol. 2005 Jul 18;170(2):201–11. PubMed Europe PMC Scholia
261. Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail. Lee MS, Edwards RA, Thede GL, Glover JNM. J Biol Chem. 2005 Sep 16;280(37):32053–6. PubMed Europe PMC Scholia
262. A role for proapoptotic BID in the DNA-damage response. Zinkel SS, Hurov KE, Ong C, Abtahi FM, Gross A, Korsmeyer SJ. Cell. 2005 Aug 26;122(4):579–91. PubMed Europe PMC Scholia
263. Proapoptotic BID is an ATM effector in the DNA-damage response. Kamer I, Sarig R, Zaltsman Y, Niv H, Oberkovitz G, Regev L, et al. Cell. 2005 Aug 26;122(4):593–603. PubMed Europe PMC Scholia
264. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Sun Y, Jiang X, Chen S, Fernandes N, Price BD. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13182–7. PubMed Europe PMC Scholia
265. Shelterin: the protein complex that shapes and safeguards human telomeres. de Lange T. Genes Dev. 2005 Sep 15;19(18):2100–10. PubMed Europe PMC Scholia
266. DNA damage-induced phosphorylation of the human telomere-associated protein TRF2. Tanaka H, Mendonca MS, Bradshaw PS, Hoelz DJ, Malkas LH, Meyn MS, et al. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15539–44. PubMed Europe PMC Scholia
267. Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. Wang X, Khaleque MA, Zhao MJ, Zhong R, Gaestel M, Calderwood SK. J Biol Chem. 2006 Jan 13;281(2):782–91. PubMed Europe PMC Scholia
268. DNA double strand breaks do not play a role in heat-induced cell killing. Kampinga HH, Laszlo A. Cancer Res. 2005 Nov 15;65(22):10632–3; author reply 10633. PubMed Europe PMC Scholia
269. Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. Smits VAJ, Reaper PM, Jackson SP. Curr Biol. 2006 Jan 24;16(2):150–9. PubMed Europe PMC Scholia
270. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP. Cell. 2005 Dec 29;123(7):1213–26. PubMed Europe PMC Scholia
271. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. Myers JS, Cortez D. J Biol Chem. 2006 Apr 7;281(14):9346–50. PubMed Europe PMC Scholia
272. Direct interaction between cohesin complex and DNA replication machinery. Ryu MJ, Kim BJ, Lee JW, Lee MW, Choi HK, Kim ST. Biochem Biophys Res Commun. 2006 Mar 17;341(3):770–5. PubMed Europe PMC Scholia
273. DNA mismatch repair: functions and mechanisms. Iyer RR, Pluciennik A, Burdett V, Modrich PL. Chem Rev. 2006 Feb;106(2):302–23. PubMed Europe PMC Scholia
274. Microcephalin encodes a centrosomal protein. Zhong X, Pfeifer GP, Xu X. Cell Cycle. 2006 Feb;5(4):457–8. PubMed Europe PMC Scholia
275. Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. Oh HJ, Lee KK, Song SJ, Jin MS, Song MS, Lee JH, et al. Cancer Res. 2006 Mar 1;66(5):2562–9. PubMed Europe PMC Scholia
276. gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. Stucki M, Jackson SP. DNA Repair (Amst). 2006 May 10;5(5):534–43. PubMed Europe PMC Scholia
277. BID as a double agent in cell life and death. Gross A. Cell Cycle. 2006 Mar;5(6):582–4. PubMed Europe PMC Scholia
278. Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas. Soung YH, Lee JW, Kim SY, Park WS, Nam SW, Lee JY, et al. APMIS. 2006 Apr;114(4):292–7. PubMed Europe PMC Scholia
279. gamma-H2AX as a therapeutic target for improving the efficacy of radiation therapy. Kao J, Milano MT, Javaheri A, Garofalo MC, Chmura SJ, Weichselbaum RR, et al. Curr Cancer Drug Targets. 2006 May;6(3):197–205. PubMed Europe PMC Scholia
280. Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks. Potts PR, Porteus MH, Yu H. EMBO J. 2006 Jul 26;25(14):3377–88. PubMed Europe PMC Scholia
281. Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Ziv Y, Bielopolski D, Galanty Y, Lukas C, Taya Y, Schultz DC, et al. Nat Cell Biol. 2006 Aug;8(8):870–6. PubMed Europe PMC Scholia
282. Checkpoint and coordinated cellular responses to DNA damage. Yang XH, Zou L. Results Probl Cell Differ. 2006;42:65–92. PubMed Europe PMC Scholia
283. Tip60 in DNA damage response and growth control: many tricks in one HAT. Squatrito M, Gorrini C, Amati B. Trends Cell Biol. 2006 Sep;16(9):433–42. PubMed Europe PMC Scholia
284. Divorcing ARF and p53: an unsettled case. Sherr CJ. Nat Rev Cancer. 2006 Sep;6(9):663–73. PubMed Europe PMC Scholia
285. Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. Callus BA, Verhagen AM, Vaux DL. FEBS J. 2006 Sep;273(18):4264–76. PubMed Europe PMC Scholia
286. Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Ho GPH, Margossian S, Taniguchi T, D’Andrea AD. Mol Cell Biol. 2006 Sep;26(18):7005–15. PubMed Europe PMC Scholia
287. DNA nucleotide excision repair-dependent signaling to checkpoint activation. Marini F, Nardo T, Giannattasio M, Minuzzo M, Stefanini M, Plevani P, et al. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17325–30. PubMed Europe PMC Scholia
288. The mitotic phosphatase cdc25C at the Golgi apparatus. Noll A, Ruppenthal SL, Montenarh M. Biochem Biophys Res Commun. 2006 Dec 29;351(4):825–30. PubMed Europe PMC Scholia
289. Nuclear exclusion of separase prevents cohesin cleavage in interphase cells. Sun Y, Yu H, Zou H. Cell Cycle. 2006 Nov 1;5(21):2537–42. PubMed Europe PMC Scholia
290. A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. Tompkins VS, Hagen J, Frazier AA, Lushnikova T, Fitzgerald MP, di Tommaso A, et al. J Biol Chem. 2007 Jan 12;282(2):1322–33. PubMed Europe PMC Scholia
291. Tyrosine phosphorylation controls PCNA function through protein stability. Wang SC, Nakajima Y, Yu YL, Xia W, Chen CT, Yang CC, et al. Nat Cell Biol. 2006 Dec;8(12):1359–68. PubMed Europe PMC Scholia
292. The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. Moldoveanu T, Liu Q, Tocilj A, Watson M, Shore G, Gehring K. Mol Cell. 2006 Dec 8;24(5):677–88. PubMed Europe PMC Scholia
293. KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions. White DE, Negorev D, Peng H, Ivanov AV, Maul GG, Rauscher FJ 3rd. Cancer Res. 2006 Dec 15;66(24):11594–9. PubMed Europe PMC Scholia
294. Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. Chen BPC, Uematsu N, Kobayashi J, Lerenthal Y, Krempler A, Yajima H, et al. J Biol Chem. 2007 Mar 2;282(9):6582–7. PubMed Europe PMC Scholia
295. Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of cornelia de Lange syndrome with predominant mental retardation. Deardorff MA, Kaur M, Yaeger D, Rampuria A, Korolev S, Pie J, et al. Am J Hum Genet. 2007 Mar;80(3):485–94. PubMed Europe PMC Scholia
296. Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents. Haince JF, Kozlov S, Dawson VL, Dawson TM, Hendzel MJ, Lavin MF, et al. J Biol Chem. 2007 Jun 1;282(22):16441–53. PubMed Europe PMC Scholia
297. Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition. Aguilar-Quesada R, Muñoz-Gámez JA, Martín-Oliva D, Peralta A, Valenzuela MT, Matínez-Romero R, et al. BMC Mol Biol. 2007 Apr 25;8:29. PubMed Europe PMC Scholia
298. A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. Mu JJ, Wang Y, Luo H, Leng M, Zhang J, Yang T, et al. J Biol Chem. 2007 Jun 15;282(24):17330–4. PubMed Europe PMC Scholia
299. E2F1 death pathways as targets for cancer therapy. Pützer BM. J Cell Mol Med. 2007;11(2):239–51. PubMed Europe PMC Scholia
300. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, et al. Science. 2007 May 25;316(5828):1160–6. PubMed Europe PMC Scholia
301. Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR. Jowsey P, Morrice NA, Hastie CJ, McLauchlan H, Toth R, Rouse J. DNA Repair (Amst). 2007 Oct 1;6(10):1536–44. PubMed Europe PMC Scholia
302. Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. Lee JH, Kim HS, Lee SJ, Kim KT. J Cell Sci. 2007 Jul 1;120(Pt 13):2259–71. PubMed Europe PMC Scholia
303. Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization. Jeffers LJ, Coull BJ, Stack SJ, Morrison CG. Oncogene. 2008 Jan 3;27(1):139–44. PubMed Europe PMC Scholia
304. Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons. Anne SL, Saudou F, Humbert S. J Neurosci. 2007 Jul 4;27(27):7318–28. PubMed Europe PMC Scholia
305. Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents. Tanaka T, Huang X, Halicka HD, Zhao H, Traganos F, Albino AP, et al. Cytometry A. 2007 Sep;71(9):648–61. PubMed Europe PMC Scholia
306. Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck. Chen K, Hu Z, Wang LE, Zhang W, El-Naggar AK, Sturgis EM, et al. Clin Cancer Res. 2007 Jul 15;13(14):4300–5. PubMed Europe PMC Scholia
307. Regulation of E2F1 function by the nuclear corepressor KAP1. Wang C, Rauscher FJ 3rd, Cress WD, Chen J. J Biol Chem. 2007 Oct 12;282(41):29902–9. PubMed Europe PMC Scholia
308. Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456. Kass EM, Ahn J, Tanaka T, Freed-Pastor WA, Keezer S, Prives C. J Biol Chem. 2007 Oct 12;282(41):30311–21. PubMed Europe PMC Scholia
309. RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Matallanas D, Romano D, Yee K, Meissl K, Kucerova L, Piazzolla D, et al. Mol Cell. 2007 Sep 21;27(6):962–75. PubMed Europe PMC Scholia
310. Delineation of the caspase-9 signaling cascade. Guerrero AD, Chen M, Wang J. Apoptosis. 2008 Jan;13(1):177–86. PubMed Europe PMC Scholia
311. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Sun Y, Xu Y, Roy K, Price BD. Mol Cell Biol. 2007 Dec;27(24):8502–9. PubMed Europe PMC Scholia
312. ATF2 on the double - activating transcription factor and DNA damage response protein. Bhoumik A, Lopez-Bergami P, Ronai Z. Pigment Cell Res. 2007 Dec;20(6):498–506. PubMed Europe PMC Scholia
313. Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression. Li X, Lee YK, Jeng JC, Yen Y, Schultz DC, Shih HM, et al. J Biol Chem. 2007 Dec 14;282(50):36177–89. PubMed Europe PMC Scholia
314. Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase. Karlsson KH, Stenerlöw B. BMC Mol Biol. 2007 Oct 26;8:97. PubMed Europe PMC Scholia
315. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, et al. Genes Dev. 2007 Nov 1;21(21):2747–61. PubMed Europe PMC Scholia
316. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, et al. Cell. 2007 Nov 30;131(5):887–900. PubMed Europe PMC Scholia
317. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Huen MSY, Grant R, Manke I, Minn K, Yu X, Yaffe MB, et al. Cell. 2007 Nov 30;131(5):901–14. PubMed Europe PMC Scholia
318. Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, et al. Science. 2007 Dec 7;318(5856):1637–40. PubMed Europe PMC Scholia
319. PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. Haince JF, McDonald D, Rodrigue A, Déry U, Masson JY, Hendzel MJ, et al. J Biol Chem. 2008 Jan 11;283(2):1197–208. PubMed Europe PMC Scholia
320. Profiling of UV-induced ATM/ATR signaling pathways. Stokes MP, Rush J, Macneill J, Ren JM, Sprott K, Nardone J, et al. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19855–60. PubMed Europe PMC Scholia
321. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. Hao Y, Chun A, Cheung K, Rashidi B, Yang X. J Biol Chem. 2008 Feb 29;283(9):5496–509. PubMed Europe PMC Scholia
322. DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication. Müller B, Blackburn J, Feijoo C, Zhao X, Smythe C. J Cell Biol. 2007 Dec 31;179(7):1385–98. PubMed Europe PMC Scholia
323. Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Ahel I, Ahel D, Matsusaka T, Clark AJ, Pines J, Boulton SJ, et al. Nature. 2008 Jan 3;451(7174):81–5. PubMed Europe PMC Scholia
324. Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. Koida N, Ozaki T, Yamamoto H, Ono S, Koda T, Ando K, et al. J Biol Chem. 2008 Mar 28;283(13):8555–63. PubMed Europe PMC Scholia
325. Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Levy D, Adamovich Y, Reuven N, Shaul Y. Mol Cell. 2008 Feb 15;29(3):350–61. PubMed Europe PMC Scholia
326. Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage. Jha S, Shibata E, Dutta A. Mol Cell Biol. 2008 Apr;28(8):2690–700. PubMed Europe PMC Scholia
327. Regulation of DNA repair throughout the cell cycle. Branzei D, Foiani M. Nat Rev Mol Cell Biol. 2008 Apr;9(4):297–308. PubMed Europe PMC Scholia
328. Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1. Huang Y, Wu M, Li HY. J Biol Chem. 2008 Apr 25;283(17):11453–60. PubMed Europe PMC Scholia
329. The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage. Bahassi EM, Ovesen JL, Riesenberg AL, Bernstein WZ, Hasty PE, Stambrook PJ. Oncogene. 2008 Jun 26;27(28):3977–85. PubMed Europe PMC Scholia
330. A comprehensive modular map of molecular interactions in RB/E2F pathway. Calzone L, Gelay A, Zinovyev A, Radvanyi F, Barillot E. Mol Syst Biol. 2008;4:173. PubMed Europe PMC Scholia
331. Identification of a novel human Rad51 variant that promotes DNA strand exchange. Park JY, Yoo HW, Kim BR, Park R, Choi SY, Kim Y. Nucleic Acids Res. 2008 Jun;36(10):3226–34. PubMed Europe PMC Scholia
332. Transcriptional control of human p53-regulated genes. Riley T, Sontag E, Chen P, Levine A. Nat Rev Mol Cell Biol. 2008 May;9(5):402–12. PubMed Europe PMC Scholia
333. Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3. Luo H, Li Y, Mu JJ, Zhang J, Tonaka T, Hamamori Y, et al. J Biol Chem. 2008 Jul 11;283(28):19176–83. PubMed Europe PMC Scholia
334. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Richard DJ, Bolderson E, Cubeddu L, Wadsworth RIM, Savage K, Sharma GG, et al. Nature. 2008 May 29;453(7195):677–81. PubMed Europe PMC Scholia
335. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, et al. Cell. 2008 May 30;133(5):864–77. PubMed Europe PMC Scholia
336. The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. Song MS, Song SJ, Kim SY, Oh HJ, Lim DS. EMBO J. 2008 Jul 9;27(13):1863–74. PubMed Europe PMC Scholia
337. Early events in the mammalian response to DNA double-strand breaks. Riches LC, Lynch AM, Gooderham NJ. Mutagenesis. 2008 Sep;23(5):331–9. PubMed Europe PMC Scholia
338. MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis. Yang SZ, Lin FT, Lin WC. EMBO Rep. 2008 Sep;9(9):907–15. PubMed Europe PMC Scholia
339. Investigation of the proapoptotic BCL-2 family member bid on the crossroad of the DNA damage response and apoptosis. Zinkel SS. Methods Enzymol. 2008;442:231–50. PubMed Europe PMC Scholia
340. ATF2: a transcription factor that elicits oncogenic or tumor suppressor activities. Bhoumik A, Ronai Z. Cell Cycle. 2008 Aug;7(15):2341–5. PubMed Europe PMC Scholia
341. Role of H2AX in DNA damage response and human cancers. Srivastava N, Gochhait S, de Boer P, Bamezai RNK. Mutat Res. 2009;681(2–3):180–8. PubMed Europe PMC Scholia
342. Cohesin subunit SMC1 associates with mitotic microtubules at the spindle pole. Wong RW, Blobel G. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15441–5. PubMed Europe PMC Scholia
343. BAX activation is initiated at a novel interaction site. Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, et al. Nature. 2008 Oct 23;455(7216):1076–81. PubMed Europe PMC Scholia
344. Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death. Tian B, Yang Q, Mao Z. Nat Cell Biol. 2009 Feb;11(2):211–8. PubMed Europe PMC Scholia
345. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, et al. Cell. 2009 Feb 6;136(3):435–46. PubMed Europe PMC Scholia
346. Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex. Du Y, Zhou J, Fan J, Shen Z, Chen X. J Proteome Res. 2009 May;8(5):2211–7. PubMed Europe PMC Scholia
347. Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. Tomimatsu N, Mukherjee B, Burma S. EMBO Rep. 2009 Jun;10(6):629–35. PubMed Europe PMC Scholia
348. The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities. Naim V, Rosselli F. Nat Cell Biol. 2009 Jun;11(6):761–8. PubMed Europe PMC Scholia
349. Transcriptional dysregulation in NIPBL and cohesin mutant human cells. Liu J, Zhang Z, Bando M, Itoh T, Deardorff MA, Clark D, et al. PLoS Biol. 2009 May 5;7(5):e1000119. PubMed Europe PMC Scholia
350. Human RIF1 encodes an anti-apoptotic factor required for DNA repair. Wang H, Zhao A, Chen L, Zhong X, Liao J, Gao M, et al. Carcinogenesis. 2009 Aug;30(8):1314–9. PubMed Europe PMC Scholia
351. The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. Malladi S, Challa-Malladi M, Fearnhead HO, Bratton SB. EMBO J. 2009 Jul 8;28(13):1916–25. PubMed Europe PMC Scholia
352. RASSF2 associates with and stabilizes the proapoptotic kinase MST2. Cooper WN, Hesson LB, Matallanas D, Dallol A, von Kriegsheim A, Ward R, et al. Oncogene. 2009 Aug 20;28(33):2988–98. PubMed Europe PMC Scholia
353. Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2. Clerici M, Mourão A, Gutsche I, Gehring NH, Hentze MW, Kulozik A, et al. EMBO J. 2009 Aug 5;28(15):2293–306. PubMed Europe PMC Scholia
354. Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction. Zhang L, Zhang J, Hu C, Cao J, Zhou X, Hu Y, et al. Anticancer Drugs. 2009 Jul;20(6):416–24. PubMed Europe PMC Scholia
355. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. Li Y, Bolderson E, Kumar R, Muniandy PA, Xue Y, Richard DJ, et al. J Biol Chem. 2009 Aug 28;284(35):23525–31. PubMed Europe PMC Scholia
356. The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells. Watrin E, Peters JM. EMBO J. 2009 Sep 2;28(17):2625–35. PubMed Europe PMC Scholia
357. SOSS complexes participate in the maintenance of genomic stability. Huang J, Gong Z, Ghosal G, Chen J. Mol Cell. 2009 Aug 14;35(3):384–93. PubMed Europe PMC Scholia
358. H2AX: functional roles and potential applications. Dickey JS, Redon CE, Nakamura AJ, Baird BJ, Sedelnikova OA, Bonner WM. Chromosoma. 2009 Dec;118(6):683–92. PubMed Europe PMC Scholia
359. Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2. Bitomsky N, Hofmann TG. FEBS J. 2009 Nov;276(21):6074–83. PubMed Europe PMC Scholia
360. NuA4 and SWR1-C: two chromatin-modifying complexes with overlapping functions and components. Lu PYT, Lévesque N, Kobor MS. Biochem Cell Biol. 2009 Oct;87(5):799–815. PubMed Europe PMC Scholia
361. Cohesin acetylation speeds the replication fork. Terret ME, Sherwood R, Rahman S, Qin J, Jallepalli PV. Nature. 2009 Nov 12;462(7270):231–4. PubMed Europe PMC Scholia
362. ATM regulates a RASSF1A-dependent DNA damage response. Hamilton G, Yee KS, Scrace S, O’Neill E. Curr Biol. 2009 Dec 15;19(23):2020–5. PubMed Europe PMC Scholia
363. HMGNs, DNA repair and cancer. Gerlitz G. Biochim Biophys Acta. 2010;1799(1–2):80–5. PubMed Europe PMC Scholia
364. Dealing with DNA damage: relationships between checkpoint and repair pathways. Warmerdam DO, Kanaar R. Mutat Res. 2010;704(1–3):2–11. PubMed Europe PMC Scholia
365. Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Bolderson E, Tomimatsu N, Richard DJ, Boucher D, Kumar R, Pandita TK, et al. Nucleic Acids Res. 2010 Apr;38(6):1821–31. PubMed Europe PMC Scholia
366. The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks. Nakamura AJ, Rao VA, Pommier Y, Bonner WM. Cell Cycle. 2010 Jan 15;9(2):389–97. PubMed Europe PMC Scholia
367. Cdk5, the multifunctional surveyor. Lalioti V, Pulido D, Sandoval IV. Cell Cycle. 2010 Jan 15;9(2):284–311. PubMed Europe PMC Scholia
368. Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation. Kilili GK, Kyriakis JM. J Biol Chem. 2010 May 14;285(20):15076–87. PubMed Europe PMC Scholia
369. Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition. Greer Card DA, Sierant ML, Davey S. J Biol Chem. 2010 May 14;285(20):15653–61. PubMed Europe PMC Scholia
370. The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells. Stolz A, Ertych N, Kienitz A, Vogel C, Schneider V, Fritz B, et al. Nat Cell Biol. 2010 May;12(5):492–9. PubMed Europe PMC Scholia
371. Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome. Sage JM, Gildemeister OS, Knight KL. J Biol Chem. 2010 Jun 18;285(25):18984–90. PubMed Europe PMC Scholia
372. SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. Li X, Lin HH, Chen H, Xu X, Shih HM, Ann DK. Sci Signal. 2010 Apr 27;3(119):ra32. PubMed Europe PMC Scholia
373. Focus on histone variant H2AX: to be or not to be. Yuan J, Adamski R, Chen J. FEBS Lett. 2010 Sep 10;584(17):3717–24. PubMed Europe PMC Scholia
374. Mechanisms of ATR-mediated checkpoint signalling. Smits VAJ, Warmerdam DO, Martin Y, Freire R. Front Biosci (Landmark Ed). 2010 Jun 1;15(3):840–53. PubMed Europe PMC Scholia
375. Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes. Garcia-Cruz R, Brieño MA, Roig I, Grossmann M, Velilla E, Pujol A, et al. Hum Reprod. 2010 Sep;25(9):2316–27. PubMed Europe PMC Scholia
376. The C terminus of p53 binds the N-terminal domain of MDM2. Poyurovsky MV, Katz C, Laptenko O, Beckerman R, Lokshin M, Ahn J, et al. Nat Struct Mol Biol. 2010 Aug;17(8):982–9. PubMed Europe PMC Scholia
377. TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage. Ye J, Lenain C, Bauwens S, Rizzo A, Saint-Léger A, Poulet A, et al. Cell. 2010 Jul 23;142(2):230–42. PubMed Europe PMC Scholia
378. Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis. Liebl J, Weitensteiner SB, Vereb G, Takács L, Fürst R, Vollmar AM, et al. J Biol Chem. 2010 Nov 12;285(46):35932–43. PubMed Europe PMC Scholia
379. ABL tyrosine kinases: evolution of function, regulation, and specificity. Colicelli J. Sci Signal. 2010 Sep 14;3(139):re6. PubMed Europe PMC Scholia
380. Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways. Gilmore-Hebert M, Ramabhadran R, Stern DF. Mol Cancer Res. 2010 Oct;8(10):1388–98. PubMed Europe PMC Scholia
381. A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. Hinz M, Stilmann M, Arslan SÇ, Khanna KK, Dittmar G, Scheidereit C. Mol Cell. 2010 Oct 8;40(1):63–74. PubMed Europe PMC Scholia
382. BRCA1 Forms a Functional Complex with γ-H2AX as a Late Response to Genotoxic Stress. Krum SA, la Rosa Dalugdugan E de, Miranda-Carboni GA, Lane TF. J Nucleic Acids. 2010 Sep 27;2010:801594. PubMed Europe PMC Scholia
383. Familial glucocorticoid receptor haploinsufficiency by non-sense mediated mRNA decay, adrenal hyperplasia and apparent mineralocorticoid excess. Bouligand J, Delemer B, Hecart AC, Meduri G, Viengchareun S, Amazit L, et al. PLoS One. 2010 Oct 22;5(10):e13563. PubMed Europe PMC Scholia
384. Regulation and role of cyclin-dependent kinase activity in neuronal survival and death. Hisanaga S ichi, Endo R. J Neurochem. 2010 Dec;115(6):1309–21. PubMed Europe PMC Scholia
385. Cohesin phosphorylation and mobility of SMC1 at ionizing radiation-induced DNA double-strand breaks in human cells. Bauerschmidt C, Woodcock M, Stevens DL, Hill MA, Rothkamm K, Helleday T. Exp Cell Res. 2011 Feb 1;317(3):330–7. PubMed Europe PMC Scholia
386. Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand. Park Y, Park J, Lee Y, Lim W, Oh BC, Shin C, et al. J Mol Med (Berl). 2011 Feb;89(2):181–91. PubMed Europe PMC Scholia
387. Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay. Franks TM, Singh G, Lykke-Andersen J. Cell. 2010 Dec 10;143(6):938–50. PubMed Europe PMC Scholia
388. Rescue of non-sense mutated p53 tumor suppressor gene by aminoglycosides. Floquet C, Deforges J, Rousset JP, Bidou L. Nucleic Acids Res. 2011 Apr;39(8):3350–62. PubMed Europe PMC Scholia
389. The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2. Guo C, Zhang X, Pfeifer GP. J Biol Chem. 2011 Feb 25;286(8):6253–61. PubMed Europe PMC Scholia
390. Signals from the nucleus: activation of NF-kappaB by cytosolic ATM in the DNA damage response. Hadian K, Krappmann D. Sci Signal. 2011 Jan 18;4(156):pe2. PubMed Europe PMC Scholia
391. Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways. Mladenov E, Iliakis G. Mutat Res. 2011 Jun 3;711(1–2):61–72. PubMed Europe PMC Scholia
392. JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. Tomlinson V, Gudmundsdottir K, Luong P, Leung KY, Knebel A, Basu S. Cell Death Dis. 2010;1(2):e29. PubMed Europe PMC Scholia
393. A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. Cotta-Ramusino C, McDonald ER 3rd, Hurov K, Sowa ME, Harper JW, Elledge SJ. Science. 2011 Jun 10;332(6035):1313–7. PubMed Europe PMC Scholia
394. Quantitative analysis of cohesin complex stoichiometry and SMC3 modification-dependent protein interactions. Ding C, Li Y, Kim BJ, Malovannaya A, Jung SY, Wang Y, et al. J Proteome Res. 2011 Aug 5;10(8):3652–9. PubMed Europe PMC Scholia
395. The role of homologous recombination in radiation-induced double-strand break repair. Jeggo PA, Geuting V, Löbrich M. Radiother Oncol. 2011 Oct;101(1):7–12. PubMed Europe PMC Scholia
396. Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding. Honda M, Okuno Y, Yoo J, Ha T, Spies M. EMBO J. 2011 Jul 29;30(16):3368–82. PubMed Europe PMC Scholia
397. DNA-damage response and repair activities at uncapped telomeres depend on RNF8. Peuscher MH, Jacobs JJL. Nat Cell Biol. 2011 Aug 21;13(9):1139–45. PubMed Europe PMC Scholia
398. Importance of PIKKs in NF-κB activation by genotoxic stress. Sabatel H, Pirlot C, Piette J, Habraken Y. Biochem Pharmacol. 2011 Nov 15;82(10):1371–83. PubMed Europe PMC Scholia
399. Checkpoint control and cancer. Medema RH, Macůrek L. Oncogene. 2012 May 24;31(21):2601–13. PubMed Europe PMC Scholia
400. Eukaryotic DNA damage checkpoint activation in response to double-strand breaks. Finn K, Lowndes NF, Grenon M. Cell Mol Life Sci. 2012 May;69(9):1447–73. PubMed Europe PMC Scholia
401. Molecular basis for the association of microcephalin (MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the anaphase-promoting complex. Singh N, Wiltshire TD, Thompson JR, Mer G, Couch FJ. J Biol Chem. 2012 Jan 20;287(4):2854–62. PubMed Europe PMC Scholia
402. Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure. Shao Z, Li F, Sy SMH, Yan W, Zhang Z, Gong D, et al. J Struct Biol. 2012 Feb;177(2):459–68. PubMed Europe PMC Scholia
403. The roles of ATF2 (activating transcription factor 2) in tumorigenesis. Gozdecka M, Breitwieser W. Biochem Soc Trans. 2012 Feb;40(1):230–4. PubMed Europe PMC Scholia
404. The role of BRCA1 and BRCA2 in prostate cancer. Castro E, Eeles R. Asian J Androl. 2012 May;14(3):409–14. PubMed Europe PMC Scholia
405. H2AX phosphorylation at the sites of DNA double-strand breaks in cultivated mammalian cells and tissues. Firsanov DV, Solovjeva LV, Svetlova MP. Clin Epigenetics. 2011 Aug;2(2):283–97. PubMed Europe PMC Scholia
406. Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography. Thompson LH. Mutat Res. 2012;751(2):158–246. PubMed Europe PMC Scholia
407. Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1. Singh N, Basnet H, Wiltshire TD, Mohammad DH, Thompson JR, Héroux A, et al. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14381–6. PubMed Europe PMC Scholia
408. BRCA1 and DNA damage response. Sedukhina A, Fukuda T, Ohta T. Seikagaku. 2012 Jul;84(7):529–38. PubMed Europe PMC Scholia
409. Sense from nonsense: therapies for premature stop codon diseases. Bidou L, Allamand V, Rousset JP, Namy O. Trends Mol Med. 2012 Nov;18(11):679–88. PubMed Europe PMC Scholia
410. The role of BRCA1 in DNA double-strand repair: past and present. Caestecker KW, Van de Walle GR. Exp Cell Res. 2013 Mar 10;319(5):575–87. PubMed Europe PMC Scholia
411. BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8. Yan Q, Xu R, Zhu L, Cheng X, Wang Z, Manis J, et al. Mol Cell Biol. 2013 Feb;33(4):845–57. PubMed Europe PMC Scholia
412. A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JTF, Tkáč J, et al. Mol Cell. 2013 Mar 7;49(5):872–83. PubMed Europe PMC Scholia
413. Prophase pathway-dependent removal of cohesin from human chromosomes requires opening of the Smc3-Scc1 gate. Buheitel J, Stemmann O. EMBO J. 2013 Mar 6;32(5):666–76. PubMed Europe PMC Scholia
414. The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy. Zhang J. Cell Biosci. 2013 Feb 6;3(1):11. PubMed Europe PMC Scholia
415. Eukaryotic mRNA decay: methodologies, pathways, and links to other stages of gene expression. Pérez-Ortín JE, Alepuz P, Chávez S, Choder M. J Mol Biol. 2013 Oct 23;425(20):3750–75. PubMed Europe PMC Scholia
416. Seventeen years after BRCA1: what is the BRCA mutation status of the breast cancer patients in Africa? - a systematic review. Oluwagbemiga LA, Oluwole A, Kayode AA. Springerplus. 2012 Dec;1(1):83. PubMed Europe PMC Scholia
417. Changes in Apaf-1 conformation that drive apoptosome assembly. Yuan S, Topf M, Reubold TF, Eschenburg S, Akey CW. Biochemistry. 2013 Apr 2;52(13):2319–27. PubMed Europe PMC Scholia
418. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, et al. J Biol Chem. 2013 May 3;288(18):12840–51. PubMed Europe PMC Scholia
419. Knocking down SMC1A inhibits growth and leads to G2/M arrest in human glioma cells. Ma Z, Lin M, Li K, Fu Y, Liu X, Yang D, et al. Int J Clin Exp Pathol. 2013 Apr 15;6(5):862–9. PubMed Europe PMC Scholia
420. Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation. Li M, Yu X. Cancer Cell. 2013 May 13;23(5):693–704. PubMed Europe PMC Scholia
421. Breast cancer genes: beyond BRCA1 and BRCA2. Filippini SE, Vega A. Front Biosci (Landmark Ed). 2013 Jun 1;18(4):1358–72. PubMed Europe PMC Scholia
422. The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse. Vasileva A, Hopkins KM, Wang X, Weisbach MM, Friedman RA, Wolgemuth DJ, et al. J Cell Sci. 2013 Sep 1;126(Pt 17):3927–38. PubMed Europe PMC Scholia
423. BRCA1 in the DNA damage response and at telomeres. Rosen EM. Front Genet. 2013 Jun 21;4:85. PubMed Europe PMC Scholia
424. Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up. Vignard J, Mirey G, Salles B. Radiother Oncol. 2013 Sep;108(3):362–9. PubMed Europe PMC Scholia
425. The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers. Ziółkowska-Suchanek I, Mosor M, Wierzbicka M, Rydzanicz M, Baranowska M, Nowak J. Mol Cancer. 2013 Sep 30;12(1):113. PubMed Europe PMC Scholia
426. DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM). Zhou Y, Paull TT. J Biol Chem. 2013 Dec 27;288(52):37112–25. PubMed Europe PMC Scholia
427. Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation. Kwak Y, Jeong J, Lee S, Park YU, Lee SA, Han DH, et al. J Biol Chem. 2013 Dec 27;288(52):36878–89. PubMed Europe PMC Scholia
428. YAP is essential for tissue tension to ensure vertebrate 3D body shape. Porazinski S, Wang H, Asaoka Y, Behrndt M, Miyamoto T, Morita H, et al. Nature. 2015 May 14;521(7551):217–21. PubMed Europe PMC Scholia
429. DSB repair model for mammalian cells in early S and G1 phases of the cell cycle: application to damage induced by ionizing radiation of different quality. Taleei R, Girard PM, Nikjoo H. Mutat Res Genet Toxicol Environ Mutagen. 2015 Feb;779:5–14. PubMed Europe PMC Scholia
430. Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response Pathways. Morgan MA, Lawrence TS. Clin Cancer Res. 2015 Jul 1;21(13):2898–904. PubMed Europe PMC Scholia
431. A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination. Wang AT, Kim T, Wagner JE, Conti BA, Lach FP, Huang AL, et al. Mol Cell. 2015 Aug 6;59(3):478–90. PubMed Europe PMC Scholia
432. ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor. Lavin MF, Kozlov S, Gatei M, Kijas AW. Biomolecules. 2015 Oct 23;5(4):2877–902. PubMed Europe PMC Scholia
433. Monte Carlo simulation of ionizing radiation induced DNA strand breaks utilizing coarse grained high-order chromatin structures. Liang Y, Yang G, Liu F, Wang Y. Phys Med Biol. 2016 Jan 7;61(1):445–60. PubMed Europe PMC Scholia
434. Aberrant splicing of the DMP1-ARF-MDM2-p53 pathway in cancer. Inoue K, Fry EA. Int J Cancer. 2016 Jul 1;139(1):33–41. PubMed Europe PMC Scholia
435. ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling. Wright RHG, Lioutas A, Le Dily F, Soronellas D, Pohl A, Bonet J, et al. Science. 2016 Jun 3;352(6290):1221–5. PubMed Europe PMC Scholia