Eicosanoid lipid synthesis map (WP4335)

Mus musculus

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In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: [[wikipedia:Eicosanoid|Wikipedia]]. This pathway is inspired by the Lipidmaps>Eicosanoids pathway [https://lipidmaps.org/resources/pathways/vanted.php]. For Homo sapiens, the information from this pathway has been integrated with the pre-existing pathway at [https://www.wikipathways.org/index.php/Pathway:WP167|WikiPathways].

Authors

Egon Willighagen , Denise Slenter , and Eric Weitz

Activity

last edited

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

inflammatory response pathway eicosanoid biosynthetic pathway

Participants

Label Type Compact URI Comment
GP Metabolite chebi:37739
AA Metabolite lipidmaps:LMFA01030001
PGG2 Metabolite lipidmaps:LMFA03010009
PGH2 Metabolite lipidmaps:LMFA03010010
PGE2 Metabolite lipidmaps:LMFA03010003
PGF2a Metabolite lipidmaps:LMFA03010002
PGD2 Metabolite wikidata:Q419750
PGJ2 Metabolite wikidata:Q27088353
15-deoxy-PGJ2 Metabolite pubchem.compound:5311211
15-deoxy-PGD2 Metabolite pubchem.compound:5283052
5-HETE Metabolite cas:70608-72-9
11-HETE Metabolite wikidata:Q27140010
Pla2g5 Protein ncbigene:18784
Pla2g6 Protein ncbigene:53357
Pla2g4a Protein ncbigene:18783
Pla2g4b Protein ncbigene:211429
Ptgs1 Protein ncbigene:74451
Ptgs2 Protein ncbigene:19225
Ptgs1 Protein ncbigene:74451
Ptgs2 Protein ncbigene:19225
Ptges Protein ncbigene:64292
Ptgds Protein uniprot:O09114
Alox5 Protein ncbigene:11689

References