Sulindac metabolic pathway (WP2541)

Rattus norvegicus

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Metabolism of sulindac involves various enzymes.

Authors

Egon Willighagen , Marianthi Kalafati , Denise Slenter , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

classic metabolic pathway xenobiotic metabolic pathway

Participants

Label Type Compact URI Comment
Sulindac sulfide Metabolite chemspider:4509492
Sulindac-S Metabolite pubchem.compound:11245227
Sulindac-R Metabolite pubchem.compound:16046677
Sulindac sulfone Metabolite chemspider:4582441 The structure for the sulfone in the paper is inconsistent with the entries in ChemSpider and PubChem; I assume the paper made typographic errors.
CYP1A1 GeneProduct ensembl:ENSRNOG00000019500
MsrB2 GeneProduct ensembl:ENSRNOG00000016873
MsrA GeneProduct ensembl:ENSRNOG00000012440
FMO GeneProduct interpro:IPR000960
MsrB3 GeneProduct ensembl:ENSRNOG00000042668
CYP1A2 GeneProduct ensembl:ENSRNOG00000016173

References

  1. Studies on the metabolism and biological activity of the epimers of sulindac. Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H. Drug Metab Dispos. 2011 Jun;39(6):1014–21. PubMed Europe PMC Scholia