Deregulation of renin-angiotensin system by SARS-CoV infection (WP4965)

Mus musculus

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The spike protein of SARS-CoV down regulates ACE2, leading to deregulation of the renin-angiotensin system. This deregulation can be the cause of lung injury that is linked to SARS-CoV infection. This work was done in a mouse model.

Authors

Jordi Doijen , Egon Willighagen , Denise Slenter , Eric Weitz , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

COVID-19

Annotations

Cell Type Ontology

native cell

Disease Ontology

viral infectious disease

Pathway Ontology

G protein mediated signaling pathway

Participants

Label Type Compact URI Comment
Angiotensin II Metabolite hmdb:HMDB0001035
Angiotensin I Metabolite hmdb:HMDB0061196
Angiotensin-(1-7) Metabolite chebi:55438
Angiotensinogen Metabolite chebi:2720
Angiotensin-(1-9) Metabolite chebi:80128
Agtr1a GeneProduct ensembl:ENSMUSG00000049115
Ace2 GeneProduct ensembl:ENSMUSG00000015405
Ace GeneProduct ensembl:ENSMUSG00000020681
Agtr2 GeneProduct ensembl:ENSMUSG00000068122

References

  1. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al. Nat Med. 2005 Aug;11(8):875–9. PubMed Europe PMC Scholia