Glucocorticoid effect on target gene expression (WP1963)

Rattus norvegicus

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This pathway provides a clear view of the effects of Glucocorticoids on target gene expression when binding to the GR (glucocorticoid receptor). Inhibiting and activiting effects are given as a result of target gene activation. It summarizes the article of Pelaia et al, 2002, which explains the pathway very detailed.

Authors

Rianne Fijten , Kristina Hanspers , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , and Eric Weitz

Activity

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

glucocorticoid signaling pathway

Participants

Label Type Compact URI Comment
Glucocorticoids Metabolite chebi:24261
p59 GeneProduct ncbigene:260321
GITR GeneProduct ensembl:ENSRNOG00000022012
COX-2 GeneProduct ensembl:ENSRNOG00000030371
phospholipase A2 GeneProduct ensembl:ENSRNOG00000002657
beta2 adrenergic receptor GeneProduct ensembl:ENSRNOG00000019217
Glucocorticoid Receptor GeneProduct ncbigene:24413
Hsp70 GeneProduct ensembl:ENSRNOG00000016596
Rras GeneProduct ensembl:ENSRNOG00000037247
Hsp90aa1 GeneProduct ensembl:ENSRNOG00000007219
Hsp90ab1 GeneProduct ensembl:ENSRNOG00000019834
Nf-kB, etc GeneProduct ensembl:ENSRNOG00000023258
IkB-alpha GeneProduct ensembl:ENSRNOG00000007390
lipocortin-1 GeneProduct ensembl:ENSRNOG00000017469
GILZ GeneProduct ensembl:ENSRNOG00000056135
Nf-kB GeneProduct ensembl:ENSRNOG00000023258

References

  1. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PB. Nature. 1991 Aug 8;352(6335):497–505. PubMed Europe PMC Scholia
  2. Post-transcriptional regulation of granulocyte-macrophage colony-stimulating factor synthesis in murine T cells. Bickel M, Cohen RB, Pluznik DH. J Immunol. 1990 Aug 1;145(3):840–5. PubMed Europe PMC Scholia
  3. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Mitchell PJ, Tjian R. Science. 1989 Jul 28;245(4916):371–8. PubMed Europe PMC Scholia
  4. Beta-adrenergic receptors and their regulation. Barnes PJ. Am J Respir Crit Care Med. 1995 Sep;152(3):838–60. PubMed Europe PMC Scholia
  5. Regulation of beta 2-adrenergic receptors and the implications for bronchial asthma: an update. Pelaia G, Marsico SA. Monaldi Arch Chest Dis. 1994 Apr;49(2):125–30. PubMed Europe PMC Scholia
  6. Lipocortin-1: cellular mechanisms and clinical relevance. Flower RJ, Rothwell NJ. Trends Pharmacol Sci. 1994 Mar;15(3):71–6. PubMed Europe PMC Scholia
  7. Steroid receptors and their associated proteins. Smith DF, Toft DO. Mol Endocrinol. 1993 Jan;7(1):4–11. PubMed Europe PMC Scholia
  8. NF-kappa B: a pivotal role in asthma and a new target for therapy. Barnes PJ, Adcock IM. Trends Pharmacol Sci. 1997 Feb;18(2):46–50. PubMed Europe PMC Scholia
  9. Efficacy and safety of inhaled corticosteroids. New developments. Barnes PJ, Pedersen S, Busse WW. Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 2):S1-53. PubMed Europe PMC Scholia
  10. Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin. Nightingale KP, Wellinger RE, Sogo JM, Becker PB. EMBO J. 1998 May 15;17(10):2865–76. PubMed Europe PMC Scholia
  11. Heat shock protein interactions with the glucocorticoid receptor. Bertorelli G, Bocchino V, Olivieri D. Pulm Pharmacol Ther. 1998 Feb;11(1):7–12. PubMed Europe PMC Scholia
  12. Repression of cyclooxygenase-2 and prostaglandin E2 release by dexamethasone occurs by transcriptional and post-transcriptional mechanisms involving loss of polyadenylated mRNA. Newton R, Seybold J, Kuitert LM, Bergmann M, Barnes PJ. J Biol Chem. 1998 Nov 27;273(48):32312–21. PubMed Europe PMC Scholia
  13. Histone deacetylases: transcriptional repression with SINers and NuRDs. Ayer DE. Trends Cell Biol. 1999 May;9(5):193–8. PubMed Europe PMC Scholia
  14. Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways. McKay LI, Cidlowski JA. Endocr Rev. 1999 Aug;20(4):435–59. PubMed Europe PMC Scholia
  15. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. Winzen R, Kracht M, Ritter B, Wilhelm A, Chen CY, Shyu AB, et al. EMBO J. 1999 Sep 15;18(18):4969–80. PubMed Europe PMC Scholia
  16. Therapeutic strategies for allergic diseases. Barnes PJ. Nature. 1999 Nov 25;402(6760 Suppl):B31-8. PubMed Europe PMC Scholia
  17. Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes. Riccardi C, Cifone MG, Migliorati G. Cell Death Differ. 1999 Dec;6(12):1182–9. PubMed Europe PMC Scholia
  18. The coregulator exchange in transcriptional functions of nuclear receptors. Glass CK, Rosenfeld MG. Genes Dev. 2000 Jan 15;14(2):121–41. PubMed Europe PMC Scholia
  19. New perspectives in asthma treatment. Pelaia G, Vatrella A, Calabrese C, Mazzarella G, Marsico SA. Allergy. 2000;55 Suppl 61:60–6. PubMed Europe PMC Scholia
  20. Molecular mechanisms of corticosteroid actions. Adcock IM, Ito K. Monaldi Arch Chest Dis. 2000 Jun;55(3):256–66. PubMed Europe PMC Scholia
  21. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Ito K, Barnes PJ, Adcock IM. Mol Cell Biol. 2000 Sep;20(18):6891–903. PubMed Europe PMC Scholia
  22. Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB. Ayroldi E, Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, et al. Blood. 2001 Aug 1;98(3):743–53. PubMed Europe PMC Scholia
  23. Cytokine modulators as novel therapies for asthma. Barnes PJ. Annu Rev Pharmacol Toxicol. 2002;42:81–98. PubMed Europe PMC Scholia
  24. MAP kinases in the immune response. Dong C, Davis RJ, Flavell RA. Annu Rev Immunol. 2002;20:55–72. PubMed Europe PMC Scholia
  25. Review of the molecular and cellular mechanisms of action of glucocorticoids for use in asthma. Umland SP, Schleimer RP, Johnston SL. Pulm Pharmacol Ther. 2002;15(1):35–50. PubMed Europe PMC Scholia
  26. Molecular mechanisms of corticosteroid actions in chronic inflammatory airway diseases. Pelaia G, Vatrella A, Cuda G, Maselli R, Marsico SA. Life Sci. 2003 Feb 21;72(14):1549–61. PubMed Europe PMC Scholia