Glycolysis and gluconeogenesis (WP534)
Homo sapiens
Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH. Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol, glucogenic amino acids, and fatty acids. Description adapted from [http://www.wikipedia.org Wikipedia]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP534 CPTAC Assay Portal]
Authors
Kdahlquist , Susan Coort , Nick Fidelman , Martijn Van Iersel , Kristina Hanspers , Thomas Kelder , Jildau Bouwman , Alex Pico , Egon Willighagen , Martina Summer-Kutmon , The Herald , Mirk Baranzini , Denise Slenter , Mark A. Hershberger , Ambar21 , Eric Weitz , and Friederike EhrhartActivity
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Cited In
- Exploring the cellular network of metabolic flexibility in the adipose tissue (2018).
- From SNPs to pathways: Biological interpretation of type 2 diabetes (T2DM) genome wide association study (GWAS) results (2018).
- WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research (2018).
- Using RNA sequencing to identify putative competing endogenous RNAs (ceRNAs) potentially regulating fat metabolism in bovine liver (2017).
- Transcriptional reprogramming of metabolic pathways in critically ill patients (2016).
- Using the Semantic Web for Rapid Integration of WikiPathways with Other Biological Online Data Resources (2016).
- Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma (2015).
- A network biology workflow to study transcriptomics data of the diabetic liver (2014).
- A patient-based iPSC-derived hepatocyte model of alcohol-associated cirrhosis reveals bioenergetic insights into disease pathogenesis (2024).
- Investigation of the relationship between COVID-19 and pancreatic cancer using bioinformatics and systems biology approaches (2024).
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Organisms
Homo sapiensCommunities
CPTACAnnotations
Pathway Ontology
glycolysis pathway glycolysis/gluconeogenesis pathway citric acid cycle pathway gluconeogenesis pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Malate | Metabolite | hmdb:HMDB0000744 | |
| 2P-Glycerate | Metabolite | hmdb:HMDB0000362 | |
| Oxaloacetate | Metabolite | hmdb:HMDB0000223 | |
| 1,3BP-Glycerate | Metabolite | hmdb:HMDB0001270 | |
| Acetyl-CoA | Metabolite | hmdb:HMDB0001206 | |
| 3P-Glycerate | Metabolite | hmdb:HMDB0000807 | |
| Fructose-1,6BP | Metabolite | hmdb:HMDB0001058 | |
| Lactate | Metabolite | hmdb:HMDB0000190 | |
| Glucose | Metabolite | hmdb:HMDB0000122 | |
| Glyceraldehyde 3P | Metabolite | hmdb:HMDB0001112 | |
| Pyruvate | Metabolite | hmdb:HMDB0000243 | |
| Fructose 6P | Metabolite | chebi:61527 | |
| Aspartate | Metabolite | hmdb:HMDB0000191 | |
| Dihydroxyacetone-P | Metabolite | hmdb:HMDB0001473 | |
| P-enolpyruvate | Metabolite | hmdb:HMDB0000263 | |
| Glucose-6P | Metabolite | chebi:75052 | Glucose-6-Phosphate (2-) |
| Glucose-6P (open) | Metabolite | chebi:57584 | D-Glucose-6-Phosphate (2-) open form |
| Fructose 6P (open) | Metabolite | chebi:57579 | fructose-6-phosphate (2-) open form |
| TPI1 | GeneProduct | ncbigene:7167 | |
| PFKP | GeneProduct | ncbigene:5214 | |
| FBP1 | GeneProduct | ncbigene:2203 | |
| ALDOA | GeneProduct | ncbigene:226 | |
| LDHAL6B | GeneProduct | ncbigene:92483 | |
| PKM1 | GeneProduct | ncbigene:5315 | |
| ALDOC | GeneProduct | ncbigene:230 | |
| SLC2A2 | GeneProduct | ncbigene:6514 | |
| GOT1 | GeneProduct | ncbigene:2805 | |
| GAPDH | GeneProduct | ensembl:ENSG00000111640 | |
| DLD | GeneProduct | ncbigene:1738 | |
| PC | GeneProduct | ncbigene:5091 | |
| PFKM | GeneProduct | ncbigene:5213 | |
| GOT2 | GeneProduct | ncbigene:2806 | |
| PGK1 | GeneProduct | ncbigene:5230 | |
| MDH1 | GeneProduct | ncbigene:4190 | |
| PKLR | GeneProduct | ncbigene:5313 | |
| SLC2A5 | GeneProduct | ncbigene:6518 | |
| PDHA1 | GeneProduct | ncbigene:5160 | |
| MDH2 | GeneProduct | ncbigene:4191 | |
| LDHA | GeneProduct | ncbigene:3939 | |
| HK1 | GeneProduct | ncbigene:3098 | |
| SLC2A1 | GeneProduct | ncbigene:6513 | |
| PGAM2 | GeneProduct | ncbigene:5224 | |
| DLAT | GeneProduct | ncbigene:1737 | |
| PFKL | GeneProduct | ncbigene:5211 | |
| ENO3 | GeneProduct | ncbigene:2027 | |
| ENO1 | GeneProduct | ncbigene:2023 | |
| LDHC | GeneProduct | ncbigene:3948 | |
| HK3 | GeneProduct | ncbigene:3101 | |
| LDHB | GeneProduct | ncbigene:3945 | |
| MPC2 | GeneProduct | ncbigene:25874 | |
| MPC1 | GeneProduct | ncbigene:51660 | |
| ENO2 | GeneProduct | ncbigene:2026 | |
| G6PC | GeneProduct | ncbigene:2538 | Not present in brain and muscle, so those organs can not produce their own glucose in the gluconeogenesis pathway |
| HK2 | GeneProduct | ncbigene:3099 | |
| PCK1 | GeneProduct | ncbigene:5105 | |
| PGK2 | GeneProduct | ncbigene:5232 | |
| SLC2A4 | GeneProduct | ncbigene:6517 | |
| FBP2 | GeneProduct | ncbigene:8789 | |
| SLC2A3 | GeneProduct | ncbigene:6515 | |
| GCK | GeneProduct | ncbigene:2645 | Gck is mainly active in liver |
| PGAM1 | GeneProduct | ncbigene:5223 | |
| PKM2 | GeneProduct | ncbigene:5315 | |
| ALDOB | GeneProduct | ncbigene:229 | |
| PGI | GeneProduct | eccode:5.3.1.9 | phosphoglucose isomerase (PGI) |
| GPI | GeneProduct | ncbigene:2821 | glucose-6-phosphate isomerase |
References
- A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, et al. Science. 2012 Jul 6;337(6090):96–100. PubMed Europe PMC Scholia