Glycolysis and gluconeogenesis (WP534)
Homo sapiens
Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH. Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol, glucogenic amino acids, and fatty acids. Description adapted from Wikipedia. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.
Authors
Kdahlquist , Susan Coort , Nick Fidelman , Martijn Van Iersel , Kristina Hanspers , Thomas Kelder , Jildau Bouwman , Alex Pico , Egon Willighagen , Martina Summer-Kutmon , The Herald , Mirk Baranzini , Denise Slenter , Mark A. Hershberger , Ambar21 , Eric Weitz , and Friederike EhrhartActivity
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Cited In
- Exploring the cellular network of metabolic flexibility in the adipose tissue (2018).
- From SNPs to pathways: Biological interpretation of type 2 diabetes (T2DM) genome wide association study (GWAS) results (2018).
- WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research (2018).
- Using RNA sequencing to identify putative competing endogenous RNAs (ceRNAs) potentially regulating fat metabolism in bovine liver (2017).
- Transcriptional reprogramming of metabolic pathways in critically ill patients (2016).
- Using the Semantic Web for Rapid Integration of WikiPathways with Other Biological Online Data Resources (2016).
- Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma (2015).
- A network biology workflow to study transcriptomics data of the diabetic liver (2014).
- A patient-based iPSC-derived hepatocyte model of alcohol-associated cirrhosis reveals bioenergetic insights into disease pathogenesis (2024).
- Investigation of the relationship between COVID-19 and pancreatic cancer using bioinformatics and systems biology approaches (2024).
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Organisms
Homo sapiensCommunities
CPTAC ONTOX Serious Request 2024 - MetaKidsAnnotations
Pathway Ontology
gluconeogenesis pathway glycolysis/gluconeogenesis pathway glycolysis pathway citric acid cycle pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Malate | Metabolite | hmdb:HMDB0000744 | |
| 2P-Glycerate | Metabolite | hmdb:HMDB0000362 | |
| Oxaloacetate | Metabolite | hmdb:HMDB0000223 | |
| 1,3BP-Glycerate | Metabolite | hmdb:HMDB0001270 | |
| Acetyl-CoA | Metabolite | hmdb:HMDB0001206 | |
| 3P-Glycerate | Metabolite | hmdb:HMDB0000807 | |
| Fructose-1,6BP | Metabolite | hmdb:HMDB0001058 | |
| Lactate | Metabolite | hmdb:HMDB0000190 | |
| Glucose | Metabolite | hmdb:HMDB0000122 | |
| Glyceraldehyde 3P | Metabolite | hmdb:HMDB0001112 | |
| Pyruvate | Metabolite | hmdb:HMDB0000243 | |
| Fructose 6P | Metabolite | chebi:61527 | |
| Aspartate | Metabolite | hmdb:HMDB0000191 | |
| Dihydroxyacetone-P | Metabolite | hmdb:HMDB0001473 | |
| P-enolpyruvate | Metabolite | hmdb:HMDB0000263 | |
| Glucose-6P | Metabolite | chebi:75052 | Glucose-6-Phosphate (2-) |
| Glucose-6P (open) | Metabolite | chebi:57584 | D-Glucose-6-Phosphate (2-) open form |
| Fructose 6P (open) | Metabolite | chebi:57579 | fructose-6-phosphate (2-) open form |
| TPI1 | GeneProduct | ncbigene:7167 | |
| PFKP | GeneProduct | ncbigene:5214 | |
| FBP1 | GeneProduct | ncbigene:2203 | |
| ALDOA | GeneProduct | ncbigene:226 | |
| LDHAL6B | GeneProduct | ncbigene:92483 | |
| PKM1 | GeneProduct | ncbigene:5315 | |
| ALDOC | GeneProduct | ncbigene:230 | |
| SLC2A2 | GeneProduct | ncbigene:6514 | |
| GOT1 | GeneProduct | ncbigene:2805 | |
| GAPDH | GeneProduct | ensembl:ENSG00000111640 | |
| DLD | GeneProduct | ncbigene:1738 | |
| PC | GeneProduct | ncbigene:5091 | |
| PFKM | GeneProduct | ncbigene:5213 | |
| GOT2 | GeneProduct | ncbigene:2806 | |
| PGK1 | GeneProduct | ncbigene:5230 | |
| MDH1 | GeneProduct | ncbigene:4190 | |
| PKLR | GeneProduct | ncbigene:5313 | |
| SLC2A5 | GeneProduct | ncbigene:6518 | |
| PDHA1 | GeneProduct | ncbigene:5160 | |
| MDH2 | GeneProduct | ncbigene:4191 | |
| LDHA | GeneProduct | ncbigene:3939 | |
| HK1 | GeneProduct | ncbigene:3098 | |
| SLC2A1 | GeneProduct | ncbigene:6513 | |
| PGAM2 | GeneProduct | ncbigene:5224 | |
| DLAT | GeneProduct | ncbigene:1737 | |
| PFKL | GeneProduct | ncbigene:5211 | |
| ENO3 | GeneProduct | ncbigene:2027 | |
| ENO1 | GeneProduct | ncbigene:2023 | |
| LDHC | GeneProduct | ncbigene:3948 | |
| HK3 | GeneProduct | ncbigene:3101 | |
| LDHB | GeneProduct | ncbigene:3945 | |
| MPC2 | GeneProduct | ncbigene:25874 | |
| MPC1 | GeneProduct | ncbigene:51660 | |
| ENO2 | GeneProduct | ncbigene:2026 | |
| G6PC | GeneProduct | ncbigene:2538 | Not present in brain and muscle, so those organs can not produce their own glucose in the gluconeogenesis pathway |
| HK2 | GeneProduct | ncbigene:3099 | |
| PCK1 | GeneProduct | ncbigene:5105 | |
| PGK2 | GeneProduct | ncbigene:5232 | |
| SLC2A4 | GeneProduct | ncbigene:6517 | |
| FBP2 | GeneProduct | ncbigene:8789 | |
| SLC2A3 | GeneProduct | ncbigene:6515 | |
| GCK | GeneProduct | ncbigene:2645 | Gck is mainly active in liver |
| PGAM1 | GeneProduct | ncbigene:5223 | |
| PKM2 | GeneProduct | ncbigene:5315 | |
| ALDOB | GeneProduct | ncbigene:229 | |
| PGI | GeneProduct | eccode:5.3.1.9 | phosphoglucose isomerase (PGI) |
| GPI | GeneProduct | ncbigene:2821 | glucose-6-phosphate isomerase |
References
- A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, et al. Science. 2012 Jul 6;337(6090):96–100. PubMed Europe PMC Scholia