Wnt signaling pathway (WP1016)

Bos taurus

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: [http://www.genome.jp/kegg/pathway/hsa/hsa04310.html KEGG].

Authors

Thomas Kelder , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

Wnt signaling pathway

Participants

Label Type Compact URI Comment
LDLR GeneProduct ensembl:ENSBTAG00000012314 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3949
WNT1 GeneProduct ensembl:ENSBTAG00000015364 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7471
WNT2 GeneProduct ensembl:ENSBTAG00000008097 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7472
WNT2B GeneProduct ensembl:ENSBTAG00000014291 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7482
WNT3 GeneProduct ensembl:ENSBTAG00000016012 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7473
WNT3A GeneProduct ensembl:ENSBTAG00000039397 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:89780
WNT4 GeneProduct ensembl:ENSBTAG00000022671 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54361
WNT5A GeneProduct ensembl:ENSBTAG00000020221 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7474
WNT5B GeneProduct ensembl:ENSBTAG00000001341 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81029
WNT6 GeneProduct ensembl:ENSBTAG00000013990 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7475
WNT7A GeneProduct ensembl:ENSBTAG00000001668 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7476
WNT7B GeneProduct ensembl:ENSBTAG00000009532 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7477
WNT10A GeneProduct ensembl:ENSBTAG00000009217 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:80326
WNT10B GeneProduct ensembl:ENSBTAG00000015347 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7480
WNT11 GeneProduct ensembl:ENSBTAG00000010820 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7481
WNT16 GeneProduct ensembl:ENSBTAG00000002940 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51384
FZD1 GeneProduct ensembl:ENSBTAG00000002107 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8321
FZD2 GeneProduct ensembl:ENSBTAG00000020590 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2535
FZD10 GeneProduct ensembl:ENSBTAG00000007047 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11211
FZD9 GeneProduct ensembl:ENSBTAG00000020742 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8326
FZD8 GeneProduct ensembl:ENSBTAG00000015072 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8325
FZD7 GeneProduct ensembl:ENSBTAG00000002283 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8324
FZD6 GeneProduct ensembl:ENSBTAG00000010529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8323
FZD5 GeneProduct ensembl:ENSBTAG00000020957 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7855
SFRP4 GeneProduct ensembl:ENSBTAG00000015366 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6424
FZD3 GeneProduct ensembl:ENSBTAG00000006621 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7976
MAPK9 GeneProduct ensembl:ENSBTAG00000004709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
MAPK10 GeneProduct ensembl:ENSBTAG00000020048 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602
RHOA GeneProduct ensembl:ENSBTAG00000004279 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387
RAC1 GeneProduct ensembl:ENSBTAG00000009233 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
DVL1 GeneProduct ensembl:ENSBTAG00000010696 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1855
DVL2 GeneProduct ensembl:ENSBTAG00000003075 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1856
DVL3 GeneProduct ensembl:ENSBTAG00000019336 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1857
PRKCB GeneProduct ensembl:ENSBTAG00000020921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579
PRKCG GeneProduct ensembl:ENSBTAG00000013550 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5582
PRKCD GeneProduct ensembl:ENSBTAG00000008719 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580
PRKCE GeneProduct ensembl:ENSBTAG00000020614 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5581
PRKCI GeneProduct ensembl:ENSBTAG00000001403 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5584
PRKCH GeneProduct ensembl:ENSBTAG00000003276 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5583
PRKD1 GeneProduct ensembl:ENSBTAG00000012789 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587
PRKCQ GeneProduct ensembl:ENSBTAG00000010664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5588
PRKCZ GeneProduct ensembl:ENSBTAG00000014119 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5590
PPP2R5E GeneProduct ensembl:ENSBTAG00000019784 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5529
PPP2R5C GeneProduct ensembl:ENSBTAG00000020192 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5527
FRAT1 GeneProduct ensembl:ENSBTAG00000007956 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10023
AXIN1 GeneProduct ensembl:ENSBTAG00000016577 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8312
CSNK1E GeneProduct ensembl:ENSBTAG00000047582 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1454
GSK3B GeneProduct ensembl:ENSBTAG00000048057 MOUSE:KG38 MOUSE
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
APC GeneProduct ensembl:ENSBTAG00000018852 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324
CTNNB1 GeneProduct ensembl:ENSBTAG00000016420 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
FBXW2 GeneProduct ensembl:ENSBTAG00000000712 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26190
PAFAH1B1 GeneProduct ensembl:ENSBTAG00000016806 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5048
MYC GeneProduct ensembl:ENSBTAG00000008409 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
CCND1 GeneProduct ensembl:ENSBTAG00000017514 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:595
CCND2 GeneProduct ensembl:ENSBTAG00000016649 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:894
CCND3 GeneProduct ensembl:ENSBTAG00000010106 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
FOSL1 GeneProduct ensembl:ENSBTAG00000006194 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8061
JUN GeneProduct ensembl:ENSBTAG00000004037 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
PLAU GeneProduct ensembl:ENSBTAG00000005947 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5328
PRKCA GeneProduct ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
LRP5 GeneProduct ensembl:ENSBTAG00000005903 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4041
KREMEN1 GeneProduct ensembl:ENSBTAG00000009773 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83999
RYK GeneProduct ensembl:ENSBTAG00000016999 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6259
ROR1 GeneProduct ensembl:ENSBTAG00000012312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4919
LRP6 GeneProduct ensembl:ENSBTAG00000011761 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4040
ROR2 GeneProduct ensembl:ENSBTAG00000005092 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4920

References

  1. Wnt signaling in disease and in development. Nusse R. Cell Res. 2005 Jan;15(1):28–32. PubMed Europe PMC Scholia