Drug induction of bile acid pathway (WP2289)
Homo sapiens
Several drug (e.g. chlozapine) and their inhibitory effects on targets of the bile acid production pathway.
Authors
Rianne Fijten , Egon Willighagen , Susan Coort , Martina Summer-Kutmon , Roelod , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
drug pathway bile acid signaling pathwayCell Type Ontology
hepatocyteLabel | Type | Compact URI | Comment |
---|---|---|---|
Chlorpromazine | Metabolite | pubchem.compound:2726 | |
Bile acids | Metabolite | chebi:3098 | |
Ezetimibe | Metabolite | pubchem.compound:150311 | |
Troglitazone | Metabolite | pubchem.compound:5591 | |
Cholesterol | Metabolite | hmdb:HMDB0000067 | |
Tetrahydrocortisone | Metabolite | hmdb:HMDB0000903 | |
Cyclosporin | Metabolite | pubchem.compound:5284373 | |
Glycocholic acid | Metabolite | hmdb:HMDB0000138 | |
Clozapine | Metabolite | pubchem.compound:135398737 | |
Taurocholic acid | Metabolite | hmdb:HMDB0000036 | |
Bilirubin | Metabolite | hmdb:HMDB0000054 | |
Isoursodeoxycholic acid | Metabolite | hmdb:HMDB0000686 | |
Deoxycholic acid | Metabolite | hmdb:HMDB0000626 | |
Methylprednisolone | Metabolite | pubchem.compound:6741 | |
Cimetidine | Metabolite | pubchem.compound:2756 | |
Phospholipids | Metabolite | chebi:16247 | |
Digoxin | Metabolite | hmdb:HMDB0001917 | |
Clarithromyci | Metabolite | pubchem.compound:84029 | |
Erythromycin | Metabolite | pubchem.compound:12560 | |
Silybin | Metabolite | pubchem.compound:31553 | |
Glyburide | Metabolite | pubchem.compound:3488 | |
Tacrolimus | Metabolite | pubchem.compound:445643 | |
Trabectedin | Metabolite | pubchem.compound:108150 | |
Phomin | Metabolite | pubchem.compound:5311281 | |
Colchicine | Metabolite | pubchem.compound:6167 | |
Ranitidine | Metabolite | hmdb:HMDB0001930 | |
Oxiglutatione | Metabolite | pubchem.compound:65359 | |
SLCO1B1 | GeneProduct | ncbigene:10599 | |
SULT2A1 | GeneProduct | ncbigene:6822 | |
CYP3A4 | GeneProduct | ncbigene:1576 | |
SLC10A1 | GeneProduct | ncbigene:6554 | |
CYP7A1 | GeneProduct | ncbigene:1581 | |
BAAT | GeneProduct | ncbigene:570 | |
ABCB1 | GeneProduct | ncbigene:5243 | |
NR1H4 | GeneProduct | ncbigene:9971 | |
SLC51A | GeneProduct | ncbigene:200931 | |
VDR | GeneProduct | ncbigene:7421 | |
NR1I3 | GeneProduct | ncbigene:9970 | |
NR1I2 | GeneProduct | ncbigene:8856 | |
SLC51B | GeneProduct | ncbigene:123264 | |
ABCC4 | GeneProduct | ncbigene:10257 | |
ABCB11 | GeneProduct | ncbigene:8647 | |
ABCC3 | GeneProduct | ncbigene:8714 | |
ABCC2 | GeneProduct | ncbigene:1244 |