FAS pathway and stress induction of HSP regulation (WP788)

Gallus gallus

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This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].

Authors

Thomas Kelder , Kristina Hanspers , Christine Chichester , Egon Willighagen , Lauren J. Dupuis , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Gallus gallus

Communities

Annotations

Pathway Ontology

FasL mediated signaling pathway

Participants

Label Type Compact URI Comment
Phosphate Metabolite hmdb:HMDB0001429
Glutathione Metabolite hmdb:HMDB0000125
Ceramide Metabolite chebi:17761
SPTAN1 GeneProduct ncbigene:374234 Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
FAF1 GeneProduct ncbigene:424629
CASP7 GeneProduct ncbigene:423901
HSPB1 GeneProduct ncbigene:396227
RIPK2 GeneProduct ncbigene:420215 receptor (TNFRSF)-interacting serine-threonine kinase 2
DFFB GeneProduct ncbigene:374158
PAK1 GeneProduct ncbigene:419083
APAF1 GeneProduct ncbigene:417926
MAPKAPK2 GeneProduct ncbigene:419847
CASP8 GeneProduct ncbigene:395284
PARP1 GeneProduct ncbigene:396199
DFFA GeneProduct ncbigene:419451
ARHGDIB GeneProduct ncbigene:417941 Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
CYCS GeneProduct ncbigene:420624
FASLG GeneProduct ncbigene:776371
FADD GeneProduct ncbigene:776859
CASP10 GeneProduct ncbigene:424081
RB1 GeneProduct ncbigene:386582
MAPK8 GeneProduct ncbigene:423778
JUN GeneProduct ncbigene:424673
MAPKAPK3 GeneProduct ncbigene:415917
MAP2K4 GeneProduct ncbigene:417312
CASP6 GeneProduct ncbigene:395477
PAK2 GeneProduct ncbigene:424860
MAP3K7 GeneProduct ncbigene:421808
LMNB1 GeneProduct ncbigene:396223
LMNB2 GeneProduct ncbigene:396222
CASP9 GeneProduct ncbigene:426970
CFLAR GeneProduct ncbigene:424080
BCL2 GeneProduct ncbigene:396282
MAP3K1 GeneProduct ncbigene:427144
CASP3 GeneProduct ncbigene:395476
PRKDC GeneProduct ncbigene:395376
LMNA GeneProduct ncbigene:396224
FAS GeneProduct ncbigene:395274

References

  1. Heat shock proteins--modulators of apoptosis in tumour cells. Creagh EM, Sheehan D, Cotter TG. Leukemia. 2000 Jul;14(7):1161–73. PubMed Europe PMC Scholia