Vitamin A1 and A5/X pathways (WP5397)

Homo sapiens

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Vitamin A5/X pathway which shows how our food results in precursors from which Vitamin A5/X (9CBC, 9CDHBC, 9CDHROL-ES and 9CDKHROL) is metabolized which is converted into Vitamin A5/X acid (9CDHRA) which binds to RXR.

Authors

Egon Willighagen , Aishwarya Iyer , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

vitamin A and metabolites signaling pathway metabolic pathway of cofactors, vitamins, nutrients retinol metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
ATBC Metabolite wikidata:Q306135 provitamin A1
9CDHROL-ES Metabolite wikidata:Q120868159
9CDHROL Metabolite wikidata:Q120868469
9CBC Metabolite wikidata:Q27135678
9CDHBC Metabolite wikidata:Q120868409
9CDHRA Metabolite wikidata:Q120868444 vitamin A5/X acid
Both R and S forms bind, but R better. The R stereoisomer is patented
9CDHRA-ES Metabolite wikidata:Q120868227
ATRA Metabolite pubchem.compound:444795 vitamin A1 acid
ATRAL Metabolite pubchem.compound:638015 vitamin A1 aldehyde
ATROL Metabolite pubchem.compound:445354 vitamin A1
ATROL-ES Metabolite wikidata:Q120868257 vitamin A1
RXRa Protein ncbigene:6256
RXRb Protein ncbigene:6257
RXRc Protein ncbigene:6258
RARa Protein ncbigene:5914
RARb Protein ncbigene:5915
RARg Protein ncbigene:5916

References

  1. An Endogenous Mammalian Retinoid X Receptor Ligand, At Last! de Lera ÁR, Krezel W, Rühl R. ChemMedChem [Internet]. 2016 May 6;11(10):1027–37. Available from: http://dx.doi.org/10.1002/cmdc.201600105 DOI Scholia
  2. 9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice. Rühl R, Krzyżosiak A, Niewiadomska-Cimicka A, Rochel N, Szeles L, Vaz B, et al. PLoS Genet. 2015 Jun 1;11(6):e1005213. PubMed Europe PMC Scholia
  3. Vitamin A5/X, a New Food to Lipid Hormone Concept for a Nutritional Ligand to Control RXR-Mediated Signaling. Krężel W, Rivas A, Szklenar M, Ciancia M, Alvarez R, de Lera AR, et al. Nutrients. 2021 Mar 12;13(3):925. PubMed Europe PMC Scholia