Peptide GPCRs (WP24)
Homo sapiens
G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Wikipedia Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
Authors
Nathan Salomonis , Alex Pico , Kristina Hanspers , Martina Summer-Kutmon , Egon Willighagen , Zahra Roudbari , and Eric WeitzActivity
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Cited In
- Machine learning and bioinformatics to identify 8 autophagy-related biomarkers and construct gene regulatory networks in dilated cardiomyopathy (2022).
- DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival (2021).
- Copy Number Variants Captured by the Array Comparative Genomic Hybridization in a Cohort of Patients Affected with Hereditary Colorectal Cancer in Sri Lanka: The First CNV Analysis Study of the Hereditary Colorectal Cancer in the Sri Lankan Population (2021).
- Transcriptome Alterations In X-Irradiated Human Gingiva Fibroblasts (2016).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
G protein mediated signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Oxytocin | Metabolite | cas:50-56-6 | |
| Bradykinin | Metabolite | hmdb:HMDB0004246 | |
| SSTR2 | GeneProduct | ncbigene:6752 | |
| IL8RA | GeneProduct | ncbigene:3577 | |
| NPY2R | GeneProduct | ncbigene:4887 |
References
- G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells. Kukkonen JP. Biochem Biophys Res Commun. 2016 Aug 5;476(4):379–85. PubMed Europe PMC Scholia