FOXP3 in COVID-19 (WP5063)
Homo sapiens
FOXP3 in Covid-19
Authors
Ilja De Wolf , Friederike Ehrhart , Eric Weitz , and Egon WillighagenActivity
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Cited In
- An NF-κB- and Therapy-Related Regulatory Network in Glioma: A Potential Mechanism of Action for Natural Antiglioma Agents (2022).
- Identification of host genomic biomarkers from multiple transcriptomics datasets for diagnosis and therapies of SARS-CoV-2 infections (2023).
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Organisms
Homo sapiensCommunities
COVID-19Annotations
Disease Ontology
COVID-19Pathway Ontology
disease pathwayCell Type Ontology
T cell| Label | Type | Compact URI | Comment |
|---|---|---|---|
| IL6ST | GeneProduct | hgnc.symbol:IL6ST | |
| IL6R | GeneProduct | hgnc.symbol:IL6R | |
| IL2RB | GeneProduct | hgnc.symbol:IL2RB | |
| FOXP3 | GeneProduct | ensembl:ENSG00000049768 | |
| IL2RA | GeneProduct | hgnc.symbol:IL2RA | |
| IL6 | GeneProduct | hgnc.symbol:IL6 | |
| STAT3 | GeneProduct | hgnc.symbol:STAT3 | |
| IL7R | GeneProduct | hgnc.symbol:IL7R | |
| IL2RG | GeneProduct | hgnc.symbol:IL2RG | |
| IL2 | GeneProduct | hgnc.symbol:IL2 | |
| STAT5A | GeneProduct | ensembl:ENSG00000126561 | |
| STAT5B | GeneProduct | ensembl:ENSG00000173757 | |
| CD86 | Protein | uniprot:P42081 | |
| CD28 | Protein | uniprot:P10747 | |
| CD80 | Protein | uniprot:P33681 | |
| MHC-II beta | Protein | pfam:PF00969 | |
| FOXP3 | Protein | uniprot:B7ZLG1 |
References
- Structure and function of the interleukin 2 receptor: affinity conversion model. Shimizu A, Kondo S, Sabe H, Ishida N, Honjo T. Immunol Rev. 1986 Aug;92:103–20. PubMed Europe PMC Scholia
- Control of regulatory T cell development by the transcription factor Foxp3. Hori S, Nomura T, Sakaguchi S. Science. 2003 Feb 14;299(5609):1057–61. PubMed Europe PMC Scholia
- CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86. Orabona C, Grohmann U, Belladonna ML, Fallarino F, Vacca C, Bianchi R, et al. Nat Immunol. 2004 Nov;5(11):1134–42. PubMed Europe PMC Scholia
- Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Nature. 2006 May 11;441(7090):235–8. PubMed Europe PMC Scholia
- Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective. Ono M, Tanaka RJ. Immunol Cell Biol. 2016 Jan;94(1):3–10. PubMed Europe PMC Scholia
- Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation. Freudenberg K, Lindner N, Dohnke S, Garbe AI, Schallenberg S, Kretschmer K. Front Immunol. 2018 Feb 2;9:125. PubMed Europe PMC Scholia
- From stability to dynamics: understanding molecular mechanisms of regulatory T cells through Foxp3 transcriptional dynamics. Bending D, Ono M. Clin Exp Immunol. 2019 Jul;197(1):14–23. PubMed Europe PMC Scholia
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Lancet. 2020 Feb 15;395(10223):497–506. PubMed Europe PMC Scholia
- The inhibition of IL-2/IL-2R gives rise to CD8+ T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia. Shi H, Wang W, Yin J, Ouyang Y, Pang L, Feng Y, et al. Cell Death Dis. 2020 Jun 8;11(6):429. PubMed Europe PMC Scholia
- T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis. Kalfaoglu B, Almeida-Santos J, Tye CA, Satou Y, Ono M. Front Immunol. 2020 Oct 8;11:589380. PubMed Europe PMC Scholia