Enterohepatic circulation of bile acids (WP5396)

Homo sapiens

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Enterohepatic circulation of bile acids showing the individual transport proteins in hepatocytes, ileocytes (ileal enterocytes), and renal proximal tubule cells. The reactions depicted in this pathway provide a continuous supply of bile acids, which are required for the digestion of food. This transport system also reduces fecal and urinary bile acid loss, while also restricting these potentially cytotoxic compounds to reach intestinal and hepatobiliary compartments.

Authors

Denise Slenter , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

bile acid transport pathway

Cell Type Ontology

hepatocyte

Participants
Query Drugst.One

Label Type Compact URI Comment
taurine (T) conjugated bile acids (BA) : T-BA Metabolite chebi:23219 Annotated with ChEBI group ID for bile acid taurine conjugates
Bile Acids Metabolite chebi:36078 Annotated with ChEBI group ID for cholanoids
Na+ Metabolite chebi:29101
ATP Metabolite chebi:15422
glycine (G) conjugated bile acids (BA) : G-BA Metabolite chebi:36255 Annotated with ChEBI group ID for bile acid glycine conjugates
T-BA Metabolite chebi:23219 Annotated with ChEBI group ID for bile acid taurine conjugates
G-BA Metabolite chebi:36255 Annotated with ChEBI group ID for bile acid glycine conjugates
BA Metabolite chebi:36078 Annotated with ChEBI group ID for cholanoids
Sulfate (S) conjugatedbile acids (BA) : S-BA Metabolite chebi:195349 Annotated with ChEBI group ID for bile acid sulfate conjugates
Glucuronide (U) conjugatedbile acids (BA) : U-BA Metabolite chebi:195350 Annotated with ChEBI group ID for bile acid glucuronide conjugates
S-BA Metabolite chebi:195349 Annotated with ChEBI group ID for bile acid sulfate conjugates
U-BA Metabolite chebi:195350 Annotated with ChEBI group ID for bile acid glucuronide conjugates
hydroxylation (H) conjugatedbile acids (BA) : H-BA Metabolite chebi:195351 Annotated with ChEBI group ID for bile acid hydroxylation conjugates
H-BA Metabolite chebi:195351 Annotated with ChEBI group ID for bile acid hydroxylation conjugates
ILBP Protein uniprot:P51161 AKA FABP6
NTCP Protein uniprot:Q14973 AKA SLC10A1
Na+ dependant uptake of Bile Acids
OATP1B1 Protein uniprot:Q9Y6L6 AKA SLCO1B1
Na+ independant uptake of Bile Acids
OATP1B3 Protein uniprot:Q9NPD5 AKA SLCO1B3
Na+ independant uptake of Bile Acids
MRP2 Protein uniprot:Q92887 AKA ABCC2
ATP dependant export of Bile Acid sulfates/glucuronides
MDR1 Protein uniprot:P08183 AKA ABCB1A (PMID:21103970), UniProt: ABCB1 (ABCB1A is used for mouse). MDR1A in Figure (PMID:21103970)
ATP dependant export of tetrahydroxylated Bile Acids
MRP3 Protein uniprot:O15438 AKA ABCC3
ATP dependant export of Bile Acids, Bile Acid sulfates/glucuronides
BSEP Protein uniprot:O95342 AKA ABCB11
ATP dependant export of Bile Acids
MRP4 Protein uniprot:O15439 AKA ABBC4 (PMID:21103970); according to UniProt ABCC4 is the correct gene name.
ATP dependant export of Bile Acids
OSTα Protein uniprot:Q86UW1 heteromeric transporter OSTα-OSTβ , assumed to be gene SLC51A based on UniProt entry (gene name not mentioned in publication)
OSTβ Protein uniprot:Q86UW2 heteromeric transporter OSTα-OSTβ , assumed to be gene SLC51B based on UniProt entry (gene name not mentioned in publication)
ASBT Protein uniprot:Q12908 AKA SLC10A2
MRP2 Protein uniprot:Q92887 AKA ABCC2
MRP4 Protein uniprot:O15439 AKA ABBC4 (PMID:21103970); according to UniProt ABCC4 is the correct gene name.
ATP dependant export of Bile Acids, Bile Acid sulfates/glucuronides
MRP3 Protein uniprot:O15438 AKA ABCC3

References

  1. Role of the intestinal bile acid transporters in bile acid and drug disposition. Dawson PA. Handb Exp Pharmacol. 2011;(201):169–203. PubMed Europe PMC Scholia