Tryptophan metabolism (WP270)

Rattus norvegicus

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This pathway describes the metabolism of tryptophan, an essential amino acid. This pathway was originally converted from rat to human, using ortholog information. Original pathway was created by Sebastien Burel.

Authors

Lynn M. Ferrante , Kristina Hanspers , Egon Willighagen , Daniela Digles , and Friederike Ehrhart

Activity

last edited

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

tryptophan metabolic pathway

Participants

Label Type Compact URI Comment
Melatonin Metabolite chebi:16796
6-Hydroxykynurenate Metabolite pubchem.compound:440752 6-Hydroxykynurenate
4,6-Dihydroxyquinoline Metabolite chebi:28799 4,6-Dihydroxyquinoline
4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate Metabolite chemspider:389617 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
5-Hydroxykynurenamine Metabolite chebi:28715 5-Hydroxykynurenamine
N-Acetylindoxyl Metabolite chebi:15363 N-Acetylindoxyl
Kynurenate Metabolite chebi:58454 4-Hydroxy-2-quinolinecarboxylic
C00332 Metabolite chebi:15345 Acetoacetyl-CoA
C01144 Metabolite chebi:15453 (S)-3-Hydroxybutanoyl-CoA
C00877 Metabolite chebi:15473 Crotonoyl-CoA
Quinolinate Metabolite chebi:29959
Indolepyruvate Metabolite pubchem.compound:803 Indolepyruvate
Indolelactate Metabolite chebi:17282 Indolelactate
5-Hydroxykynurenine Metabolite chebi:2076
N-Acetylisatin Metabolite chebi:16050 N-Acetylisatin
Acetyl-CoA Metabolite chebi:15351 Acetyl-CoA
L-Kynurenine Metabolite chebi:16946 L-Kynurenine
Formylkynurenine Metabolite chebi:18377 Formylkynurenine
Indole Metabolite chebi:35581
Indole-3-acetamide Metabolite chebi:16031 Indole-3-acetamide
L-Tryptophan Metabolite chebi:16828
2-Aminophenol Metabolite chebi:18112 2-Aminophenol
Tryptamine Metabolite chebi:16765
Ido1 GeneProduct ncbigene:66029
Cyp2j4 GeneProduct ncbigene:65210
Asmt GeneProduct ncbigene:246281
Prmt1 GeneProduct ncbigene:60421
Aanat GeneProduct ncbigene:25120
Mdm2 GeneProduct ncbigene:314856
Maob GeneProduct ncbigene:25750
Ddc GeneProduct ncbigene:24311
Acat1 GeneProduct ncbigene:25014
Hsd17b10 GeneProduct ncbigene:63864
Echs1 GeneProduct ncbigene:140547
Gcdh GeneProduct ncbigene:364975 predicted
Ogdh GeneProduct ncbigene:360975
Acmsd GeneProduct ncbigene:171385
Haao GeneProduct ncbigene:56823
Kynu GeneProduct ncbigene:116682
Tdo2 GeneProduct ncbigene:64206
Tph1 GeneProduct ncbigene:24848
Wars GeneProduct ncbigene:314442
Cat GeneProduct ncbigene:24248
Aadat GeneProduct ncbigene:29416
Dhcr24 GeneProduct ncbigene:298298 predicted
Aldh3a2 GeneProduct ncbigene:65183
Cyp7b1 GeneProduct ncbigene:25429
AFMID GeneProduct ncbigene:688283
Aox1 GeneProduct ncbigene:54349
Dd5 GeneProduct ncbigene:117060
Abp1 GeneProduct ncbigene:65029
Inmt GeneProduct ncbigene:368066
Cyp1a1 GeneProduct ncbigene:24296
Cyp1a2 GeneProduct ncbigene:24297
Cyp2a1 GeneProduct ncbigene:24894
Cyp2a2 GeneProduct ncbigene:24895
Cyp2d2 GeneProduct ncbigene:25053
Cyp2e1 GeneProduct ncbigene:25086
Cyp19a1 GeneProduct ncbigene:25147
Cyp1b1 GeneProduct ncbigene:25426
Cyp2c80 GeneProduct ncbigene:292330
Cyp2b15 GeneProduct ncbigene:685222
Cyp2f4 GeneProduct ncbigene:54246
Cyp4f1 GeneProduct ncbigene:56266
Hadh GeneProduct ncbigene:113965
Aldh1a2 GeneProduct ncbigene:116676
Aldh1a1 GeneProduct ncbigene:24188
Aldh2 GeneProduct ncbigene:29539
Aldh9a1 GeneProduct ncbigene:64040
Ube3a GeneProduct ncbigene:361585
Rnf25 GeneProduct ncbigene:301515

References