Phosphatidylcholine catabolism (WP4195)
Homo sapiens
Schematic representation of phosphatidylcholine catabolism. Formation of various metabolites formed from phosphatidylcholine catabolism, which are signaling molecules.
Authors
Denise Slenter and Egon WillighagenActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
phosphatidylcholine biosynthetic pathway phosphatidylcholine metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| acetylcholine | Metabolite | wikidata:Q180623 | |
| Stearoyl(18:0) CoA | Metabolite | wikidata:Q27124612 | |
| Acyl-CoA | Metabolite | wikidata:Q2699537 | |
| PC(18:0/20:4) | Metabolite | cas:35418-59-8 | phosphatidylcholine = PC |
| sphingomyelin | Metabolite | chebi:17636 | |
| Lyso-PC(/20:4) | Metabolite | cas:108341-80-6 | |
| Choline | Metabolite | chebi:15354 | |
| FFA | Metabolite | chebi:35366 | Free fatty acids |
| ATP | Metabolite | chebi:15422 | |
| phosphocholine | Metabolite | chebi:295975 | |
| CoA | Metabolite | wikidata:Q407635 | |
| Glycerol 3-phosphate | Metabolite | wikidata:Q26711901 | |
| FFA(18:0) | Metabolite | wikidata:Q209685 | |
| Lyso-PC | Metabolite | chebi:36313 | |
| betaine | Metabolite | wikidata:Q10860583 | |
| Lyso-PA(/20:4) | Metabolite | wikidata:Q27105014 | |
| PA(18:0/20:4) | Metabolite | wikidata:Q27146827 | phosphatidic acid = PA |
| AA | Metabolite | wikidata:Q407699 | arachidonic acid = AA ? |
| glycerol-phosphocholine | Metabolite | wikidata:Q28529699 | In Figure spelled as glycerophosphocholine, in text as glycerol-phosphocholine |
| ADP | Metabolite | chebi:16761 | |
| PLD | Protein | eccode:3.1.4.4 | phospholipase D |
| sphingomyelinases | Protein | eccode:3.1.4.12 | |
| choline kinase | Protein | eccode:2.7.1.32 | |
| PLA1 | Protein | eccode:3.1.1.32 | phospholipase A1 |
| Acyltransferase | Protein | eccode:2.3.1 | |
| PA-PLA1 | Protein | uniprot:D3K5P3 | |
| cPLA2 | Protein | eccode:3.1.1.4 | phospholipase A2 |
| PDE | Protein | eccode:3.1.4 | a phosphodiesterase |
| LysoPLA1 | Protein | eccode:3.1.1.5 | lysophospholipase |
| ACS | Protein | eccode:6.2.1.3 | acyl-CoA synthetase |
| LysoPLA2* | Protein | eccode:3.1.1.5 | lysophospholipase |
References
- The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. Gibellini F, Smith TK. IUBMB Life. 2010 Jun;62(6):414–28. PubMed Europe PMC Scholia