Cholesterol metabolism (WP5304)

Homo sapiens

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
This pathway includes the following processes regarding cholesterol metabolism: I) Absorption of cholesterol in the enterocyte, II) Forming of chylomicrons and other lipid droplets, III) Distinction between Bloch and Kandutsch-Russell cholesterol biosynthesis, IV) Absorption of cholesterol in the hepatocyte and V) Transintestinal cholesterol excretion (TICE).

Authors

Tom Pauly , Susan Coort , Egon Willighagen , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

cholesterol transport pathway cholesterol biosynthetic pathway cholesterol metabolic pathway

Cell Type Ontology

enterocyte hepatocyte

Participants
Query Drugst.One

Label Type Compact URI Comment
27-Hydroxycholesterol Metabolite chebi:17703
Bile acid Metabolite chebi:22868
7-alpha-hydroxycholesterol Metabolite chebi:17500
Zymosterol Metabolite chebi:18252
Lanosterol Metabolite chebi:16521
Desmosterol Metabolite chebi:17737
Esterase Metabolite hmdb:HMDB0302632
Zymostenol Metabolite chebi:16608
Phospholipase Metabolite hmdb:HMDB0302979
24,25-dihydrolanosterol Metabolite chebi:28113
Phospholipid Metabolite chebi:16247
Cholesterol Metabolite chebi:16113
Cholesteryl ester Metabolite chebi:17002
Triacylglycerol Metabolite chebi:17855
Fatty acid Metabolite chebi:35366
Diacylglycerol Metabolite chebi:18035
Monoacylglycerol Metabolite chebi:17408
DGL Metabolite chebi:15966
Lysophospholipid Metabolite chebi:16961
triacylglycerols Metabolite chebi:17855
Cholesterol ester Metabolite chebi:17002
(S)-2,3-Epoxysqualene Metabolite chebi:15441
Mevalonicacid Metabolite cas:150-97-0
Farnesylpyrophosphate Metabolite cas:13058-04-3
Lathosterol Metabolite cas:80-99-9
Mevalonic acid 5-pyrophosphate Metabolite cas:1492-08-6
7-Dehydrocholesterol Metabolite cas:434-16-2
Isopentenylpyrophosphate Metabolite cas:358-71-4
HMG-CoA Metabolite hmdb:HMDB0001375
Geranyl-PP Metabolite cas:6699-20-3
Cholesterol Metabolite cas:57-88-5
Mevalonic acid-5P Metabolite cas:73566-35-5
Squalene Metabolite cas:111-02-4
Acetyl-CoA Metabolite cas:72-89-9
Dimethylallylpyrophosphate Metabolite cas:358-72-5
Mevalonic acid Metabolite cas:150-97-0
Isopentenyl pyrophosphate Metabolite cas:358-71-4
Dimethylallyl pyrophosphate Metabolite cas:358-72-5
lanosterol Metabolite chebi:16521
farnesyl pyrophosphate Metabolite cas:13058-04-3
desmosterol Metabolite chebi:17737
LCAT GeneProduct ensembl:ENSG00000213398
ABCG5 GeneProduct ensembl:ENSG00000138075
SOAT1 GeneProduct ensembl:ENSG00000057252
STAR GeneProduct ensembl:ENSG00000147465
SLC27A4 GeneProduct ensembl:ENSG00000167114
MTTP GeneProduct ensembl:ENSG00000138823
LRP1 GeneProduct ensembl:ENSG00000123384
APOH GeneProduct ensembl:ENSG00000091583
NPC2 GeneProduct ensembl:ENSG00000119655
APOA4 GeneProduct ensembl:ENSG00000110244
SORT1 GeneProduct ensembl:ENSG00000134243
LDLR GeneProduct ensembl:ENSG00000130164
APOC2 GeneProduct ensembl:ENSG00000234906
APOC3 GeneProduct ensembl:ENSG00000110245
ANGPTL8 GeneProduct ensembl:ENSG00000130173
APOC1 GeneProduct ensembl:ENSG00000130208
LBR GeneProduct ensembl:ENSG00000143815
CYP51A1 GeneProduct ensembl:ENSG00000001630
APOA1 GeneProduct ensembl:ENSG00000118137
PLTP GeneProduct ncbigene:5360
LPL GeneProduct ensembl:ENSG00000175445
APOA2 GeneProduct ensembl:ENSG00000158874
APOB GeneProduct ensembl:ENSG00000084674
CETP GeneProduct ensembl:ENSG00000087237
CYP7A1 GeneProduct ensembl:ENSG00000167910
LRPAP1 GeneProduct ensembl:ENSG00000163956
CIDEB GeneProduct ensembl:ENSG00000136305
APOE GeneProduct ensembl:ENSG00000130203
DHCR24 GeneProduct ensembl:ENSG00000116133
TSPO GeneProduct ensembl:ENSG00000100300
PCSK9 GeneProduct ensembl:ENSG00000169174
DGAT1 GeneProduct ensembl:ENSG00000185000
VAPA GeneProduct ensembl:ENSG00000101558
MGAT1 GeneProduct ensembl:ENSG00000131446
OSBPL5 GeneProduct ensembl:ENSG00000021762
HSD17B7 GeneProduct ensembl:ENSG00000132196
LIPG GeneProduct ensembl:ENSG00000101670
NPC1 GeneProduct hgnc.symbol:NPC1
LPA GeneProduct ensembl:ENSG00000198670
STARD3 GeneProduct ensembl:ENSG00000131748
ANGPTL3 GeneProduct ensembl:ENSG00000132855
LDLRAP1 GeneProduct ensembl:ENSG00000157978
EBP GeneProduct ensembl:ENSG00000147155
CD36 GeneProduct ensembl:ENSG00000135218
SCARB1 GeneProduct ensembl:ENSG00000073060
TM7SF2 GeneProduct ensembl:ENSG00000149809
ABCA1 GeneProduct ensembl:ENSG00000165029
VDAC1 GeneProduct ensembl:ENSG00000213585
MYLIP GeneProduct ensembl:ENSG00000007944
CYP27A1 GeneProduct ensembl:ENSG00000135929
LIPC GeneProduct ensembl:ENSG00000166035
ABCB11 GeneProduct ensembl:ENSG00000073734
LIPA GeneProduct ensembl:ENSG00000107798
ABCG8 GeneProduct ncbigene:64241
ABCG5 GeneProduct ncbigene:64240
NPC1L1 GeneProduct ensembl:ENSG00000015520
ACAT2 GeneProduct ensembl:ENSG00000120437
SAR1B GeneProduct ensembl:ENSG00000152700
NSDHL GeneProduct ncbigene:50814 NAD(P) dependent steroid dehydrogenase-like
FDPS GeneProduct ncbigene:2224
HMGCS1 GeneProduct ncbigene:3157
SC4MOL GeneProduct ncbigene:6307
SQLE GeneProduct ncbigene:6713
IDI1 GeneProduct ncbigene:3422
MVD GeneProduct ncbigene:4597
HMGCR GeneProduct ncbigene:3156
DHCR7 GeneProduct ncbigene:1717
PMVK GeneProduct ncbigene:10654
SC5DL GeneProduct ncbigene:6309
FDFT1 GeneProduct ncbigene:2222
LSS GeneProduct ncbigene:4047
MVK GeneProduct ncbigene:4598
FABP2 GeneProduct ensembl:ENSG00000145384
Triacylglycerol lipase Protein uniprot:A0A087WX88
Apolipoprotein B-100 Protein uniprot:A8MUN2

References

  1. Cholesterol esterase activity of human intestinal mucosa. Ponz de Leon M, Carubbi F, Di Donato P, Carulli N. Dig Dis Sci. 1985 Nov;30(11):1053–64. PubMed Europe PMC Scholia
  2. Phospholipases: structural and functional motifs for working at an interface. Roberts MF. FASEB J. 1996 Aug;10(10):1159–72. PubMed Europe PMC Scholia
  3. Malformation syndromes due to inborn errors of cholesterol synthesis. Porter FD. J Clin Invest. 2002 Sep;110(6):715–24. PubMed Europe PMC Scholia
  4. Lecithin: cholesterol acyltransferase--from biochemistry to role in cardiovascular disease. Rousset X, Vaisman B, Amar M, Sethi AA, Remaley AT. Curr Opin Endocrinol Diabetes Obes. 2009 Apr;16(2):163–71. PubMed Europe PMC Scholia
  5. Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways. Mitsche MA, McDonald JG, Hobbs HH, Cohen JC. Elife. 2015 Jun 26;4:e07999. PubMed Europe PMC Scholia
  6. Mechanisms by Which LRP1 (Low-Density Lipoprotein Receptor-Related Protein-1) Maintains Arterial Integrity. Gonias SL. Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2548–9. PubMed Europe PMC Scholia
  7. The TICE Pathway: Mechanisms and Lipid-Lowering Therapies. Grefhorst A, Verkade HJ, Groen AK. Methodist Debakey Cardiovasc J. 2019;15(1):70–6. PubMed Europe PMC Scholia
  8. Rare dyslipidaemias, from phenotype to genotype to management: a European Atherosclerosis Society task force consensus statement. Hegele RA, Borén J, Ginsberg HN, Arca M, Averna M, Binder CJ, et al. Lancet Diabetes Endocrinol. 2020 Jan;8(1):50–67. PubMed Europe PMC Scholia
  9. Regulation of intestinal lipid metabolism: current concepts and relevance to disease. Ko CW, Qu J, Black DD, Tso P. Nat Rev Gastroenterol Hepatol. 2020 Mar;17(3):169–83. PubMed Europe PMC Scholia
  10. Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities. Huang B, Song BL, Xu C. Nat Metab. 2020 Feb;2(2):132–41. PubMed Europe PMC Scholia
  11. Addressing dyslipidemic risk beyond LDL-cholesterol. Tall AR, Thomas DG, Gonzalez-Cabodevilla AG, Goldberg IJ. J Clin Invest. 2022 Jan 4;132(1):e148559. PubMed Europe PMC Scholia