Soluble ACE2-mediated cell entry of SARS-CoV-2 (WP5076)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
ACE2 is a regulator of the renin-angiotensin system. To perform this function, ACE2 is transported to the cell surface, where it is cleaved by disintegrin and ADAM17 to produce an enzymatically active soluble form of ACE2. This soluble form retains the SARS-CoV-2 binding site. SARS-CoV-2 bound to either soluble ACE2 or soluble ACE2 and vasopressin then uses receptor-mediated endocytosis by through either AT1 or AVPR1B, respectively. This figure is based on the graphical abstract from [https://www.cell.com/cell/fulltext/S0092-8674(21)00283-X Yeung et al.].

Authors

Kristina Hanspers , Eric Weitz , and Nhung Pham

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

COVID-19

Annotations

Disease Ontology

severe acute respiratory syndrome COVID-19 viral infectious disease

Pathway Ontology

endocytosis pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Vasopressin Metabolite hmdb:HMDB01980
sACE2 GeneProduct ensembl:ENSG00000130234
ADAM17 GeneProduct ensembl:ENSG00000151694
AGTR1 GeneProduct ensembl:ENSG00000144891
AVPR1B GeneProduct ensembl:ENSG00000198049
ACE2 GeneProduct ensembl:ENSG00000130234
S1 Protein wikidata:Q106020256

References

  1. Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. Yeung ML, Teng JLL, Jia L, Zhang C, Huang C, Cai JP, et al. Cell. 2021 Apr 15;184(8):2212-2228.e12. PubMed Europe PMC Scholia