Vitamin D in inflammatory diseases (WP4482)

Homo sapiens

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Vitamin D in inflammatory diseases. Inhibition of the p38 MAP kinase pathway. Proinflammatory stimuli lead to p38MAP kinase phosphorylation and activation which subsequently induces expression of many proinflammatory proteins. MED14 is part of the mediator complex involved in the regulation of transcriptional initiation and it was found to form a complex with VDR and mediate ligand-dependent enhancement of transcription by the VDR. SMAD, NFAT and NFκB signaling and modulation of these signaling pathways by VDR/RXR.

Authors

Laurent Winckers , Egon Willighagen , Andra Waagmeester , Kristina Hanspers , Denise Slenter , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

vitamin D metabolic pathway infectious disease pathway

Disease Ontology

disease by infectious agent

Participants
Query Drugst.One

Label Type Compact URI Comment
Vitamin D Metabolite chebi:27300
Cortisol Metabolite wikidata:Q190875
NFKB1 GeneProduct ncbigene:4790
IkKA GeneProduct ncbigene:1147
IkKB GeneProduct ncbigene:3551
IkKG GeneProduct ncbigene:8517
RELA GeneProduct ncbigene:5970
IkBA GeneProduct ncbigene:4792
IL6 GeneProduct ncbigene:3569
TNF GeneProduct ncbigene:7124
RXR GeneProduct ncbigene:6256
SMAD4 GeneProduct ncbigene:4089
PPP3CA GeneProduct ncbigene:5530
PPP3R1 GeneProduct ncbigene:5534
MAP2K3 GeneProduct ncbigene:5606
SMAD3 GeneProduct ncbigene:4088
NFAT GeneProduct ncbigene:4772
MKP1 GeneProduct ncbigene:1843
p38 GeneProduct ncbigene:1432
MAP2K6 GeneProduct ncbigene:5608
MAP3K1 GeneProduct ncbigene:4214
VDR GeneProduct ncbigene:7421
Med14 GeneProduct ncbigene:9282
GCR GeneProduct ncbigene:2908

References

  1. The nuclear factor NF-kappaB pathway in inflammation. Lawrence T. Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651. PubMed Europe PMC Scholia
  2. Vitamin D in inflammatory diseases. Wöbke TK, Sorg BL, Steinhilber D. Front Physiol. 2014 Jul 2;5:244. PubMed Europe PMC Scholia