Endothelin pathways (WP3246)
Bos taurus
Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation.
Authors
Martina Summer-Kutmon and Eric WeitzActivity
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Cited In
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Organisms
Bos taurusCommunities
Renal Genomics PathwaysAnnotations
Disease Ontology
hypertension benign essential hypertensionCell Type Ontology
smooth muscle cell blood vessel endothelial cellPathway Ontology
calcium/calmodulin dependent signaling pathway G protein mediated signaling pathway via Galphai family G protein mediated signaling pathway via Galphas family Ras superfamily mediated signaling pathway G protein mediated signaling pathway via Galphaq family endothelin signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| GTP | Metabolite | hmdb:HMDB0001440 | |
| L-Arginine | Metabolite | hmdb:HMDB0000517 | |
| K+ | Metabolite | hmdb:HMDB0000586 | |
| cGMP | Metabolite | hmdb:HMDB0001314 | |
| K+ | Metabolite | hmdb:HMDB0000586 | |
| NO | Metabolite | hmdb:HMDB0003378 | |
| ATP | Metabolite | hmdb:HMDB0001532 | |
| cAMP | Metabolite | hmdb:HMDB0000058 | |
| Citrulline | Metabolite | hmdb:HMDB0000904 | |
| Arachidonic acid | Metabolite | hmdb:HMDB0001043 | |
| IP3 | Metabolite | hmdb:HMDB0001059 | |
| DAG | Metabolite | hmdb:HMDB0007008 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| PIP2 | Metabolite | hmdb:HMDB0010032 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| PIP2 | Metabolite | hmdb:HMDB0010032 | |
| IP3 | Metabolite | hmdb:HMDB0001059 | |
| DAG | Metabolite | hmdb:HMDB0007008 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| NO | Metabolite | hmdb:HMDB0003378 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| K+ | Metabolite | hmdb:HMDB0000586 | |
| K+ | Metabolite | hmdb:HMDB0000586 | |
| K+ | Metabolite | hmdb:HMDB0000586 | |
| K+ | Metabolite | hmdb:HMDB0000586 | |
| NO | Metabolite | hmdb:HMDB0003378 | |
| NO | Metabolite | hmdb:HMDB0003378 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| RAMP1 | GeneProduct | ensembl:ENSBTAG00000011534 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132329 |
| NPY1R | GeneProduct | ensembl:ENSBTAG00000047586 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164128 |
| CT | GeneProduct | ensembl:ENSBTAG00000047380 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110680 |
| ATP2A2 | GeneProduct | ensembl:ENSBTAG00000001398 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174437 |
| RIIAD1 | GeneProduct | ensembl:ENSBTAG00000032733 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000178796 |
| ADCY10 | GeneProduct | ensembl:ENSBTAG00000001052 | adenylate cyclaseHomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143199 |
| COII | GeneProduct | ensembl:ENSBTAG00000043556 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4513 |
| ADRA1A | GeneProduct | ensembl:ENSBTAG00000031632 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120907 |
| NPY | GeneProduct | ensembl:ENSBTAG00000004503 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122585 |
| CALCRL | GeneProduct | ensembl:ENSBTAG00000008483 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000064989 |
| PTGIR | GeneProduct | ensembl:ENSBTAG00000014585 | Prostaglandin I2 ReceptorHomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160013 |
| NOS3 | GeneProduct | ensembl:ENSBTAG00000017680 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164867 |
| EDN1 | GeneProduct | ensembl:ENSBTAG00000008096 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078401 |
| ECE1 | GeneProduct | ensembl:ENSBTAG00000002977 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117298 |
| CNN1 | GeneProduct | ensembl:ENSBTAG00000011207 | Calponin; tonically inhibits the ATPase activity of myosin in smooth muscleType your comment hereHomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130176 |
| PRKCA | GeneProduct | ensembl:ENSBTAG00000001061 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154229 |
| GNA15 | GeneProduct | ensembl:ENSBTAG00000019988 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000060558 |
| MYL1 | GeneProduct | ensembl:ENSBTAG00000009707 | myosine light chainHomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168530 |
| MAP2K1 | GeneProduct | ensembl:ENSBTAG00000033983 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169032 |
| EDNRA | GeneProduct | ensembl:ENSBTAG00000013674 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151617 |
| MYLK | GeneProduct | ensembl:ENSBTAG00000014567 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065534 |
| MAPK1 | GeneProduct | ensembl:ENSBTAG00000010312 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030 |
| EDNRB | GeneProduct | ensembl:ENSBTAG00000005299 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136160 |
| RAF1 | GeneProduct | ensembl:ENSBTAG00000045748 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132155 |
| PLCB1 | GeneProduct | ensembl:ENSBTAG00000008338 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182621 |
| CAD | GeneProduct | ensembl:ENSBTAG00000017894 | Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contractionType your comment hereHomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000084774 |
| EDN1 | GeneProduct | ensembl:ENSBTAG00000008096 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078401 |
| GNB5 | GeneProduct | ensembl:ENSBTAG00000003762 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966 |
| GNG13 | GeneProduct | ensembl:ENSBTAG00000033526 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588 |
| EDNRB | GeneProduct | ensembl:ENSBTAG00000005299 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136160 |
| GNA15 | GeneProduct | ensembl:ENSBTAG00000019988 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000060558 |
| GNB5 | GeneProduct | ensembl:ENSBTAG00000003762 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966 |
| GNG13 | GeneProduct | ensembl:ENSBTAG00000033526 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588 |
| PLCB1 | GeneProduct | ensembl:ENSBTAG00000008338 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182621 |
| PRKCA | GeneProduct | ensembl:ENSBTAG00000001061 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154229 |
| GNAS | GeneProduct | ensembl:ENSBTAG00000017475 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087460 |
| GNB5 | GeneProduct | ensembl:ENSBTAG00000003762 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966 |
| GNG13 | GeneProduct | ensembl:ENSBTAG00000033526 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588 |
| GNA15 | GeneProduct | ensembl:ENSBTAG00000019988 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000060558 |
| GNB5 | GeneProduct | ensembl:ENSBTAG00000003762 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966 |
| GNG13 | GeneProduct | ensembl:ENSBTAG00000033526 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588 |
| ADRB1 | GeneProduct | ensembl:ENSBTAG00000001242 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000043591 |
| GNAS | GeneProduct | ensembl:ENSBTAG00000017475 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087460 |
| GNB5 | GeneProduct | ensembl:ENSBTAG00000003762 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966 |
| GNG13 | GeneProduct | ensembl:ENSBTAG00000033526 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588 |
| CT | GeneProduct | ensembl:ENSBTAG00000047380 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110680 |
| CT | GeneProduct | ensembl:ENSBTAG00000047380 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110680 |
| GNAS | GeneProduct | ensembl:ENSBTAG00000017475 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087460 |
| GNB5 | GeneProduct | ensembl:ENSBTAG00000003762 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966 |
| GNG13 | GeneProduct | ensembl:ENSBTAG00000033526 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588 |
| NPY | GeneProduct | ensembl:ENSBTAG00000004503 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122585 |
| NPY | GeneProduct | ensembl:ENSBTAG00000004503 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122585 |
| GNAI1 | GeneProduct | ensembl:ENSBTAG00000002714 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127955 |
| GNB5 | GeneProduct | ensembl:ENSBTAG00000003762 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966 |
| GNG13 | GeneProduct | ensembl:ENSBTAG00000033526 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588 |