Small cell lung cancer (WP4658)

Homo sapiens

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Small cell lung carcinoma (SCLC) is a highly malignant cancer of the lung. Genes altered in small cell lung carcinoma: * TP53 is mutated in 70-90% of SCLCs. * RB1 is inactivated in most SCLCs. * PTEN is mutated in 2-10% of SCLCs. * MYC amplifications and amplification of MYC family members is found in 30% of SCLCs. * FHIT protein expression is lost due to Loss of heterozygocity (LOH) on chromosome arm 3p found in more than 80% of SCLCs. This description was adapted from [https://en.wikipedia.org/wiki/Small-cell_carcinoma Wikipedia]. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.

Authors

Kristina Hanspers , Friederike Ehrhart , Finterly Hu , Egon Willighagen , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

CPTAC Diseases

Annotations

Pathway Ontology

small cell lung carcinoma pathway cancer pathway signaling pathway

Disease Ontology

lung cancer cancer

Participants
Query Drugst.One

Label Type Compact URI Comment
Rimiducid Metabolite wikidata:Q27279658
Venetoclax Metabolite chebi:133021
Retinoic acid Metabolite chebi:6067
PIP3 Metabolite hmdb:HMDB0004249
Oblimersen Metabolite wikidata:Q7075165
Obatoclax Metabolite wikidata:Q7074645
RXRA GeneProduct ensembl:ENSG00000186350
CKS1B GeneProduct ensembl:ENSG00000173207
MYC GeneProduct ensembl:ENSG00000136997
CASP8 GeneProduct ensembl:ENSG00000064012
FHIT GeneProduct ensembl:ENSG00000189283
BID GeneProduct ensembl:ENSG00000015475
RARB GeneProduct ensembl:ENSG00000077092
RXRB GeneProduct ensembl:ENSG00000204231
RXRG GeneProduct ensembl:ENSG00000143171
TP53 GeneProduct ensembl:ENSG00000141510
CDKN1A GeneProduct ensembl:ENSG00000124762
BAX GeneProduct ensembl:ENSG00000087088
DDB2 GeneProduct ensembl:ENSG00000134574
POLK GeneProduct ensembl:ENSG00000122008
BAK1 GeneProduct ensembl:ENSG00000030110
GADD45G GeneProduct ensembl:ENSG00000130222
GADD45A GeneProduct ensembl:ENSG00000116717
GADD45B GeneProduct ensembl:ENSG00000099860
BCL2 GeneProduct ensembl:ENSG00000171791
CYCS GeneProduct ensembl:ENSG00000172115
APAF1 GeneProduct ensembl:ENSG00000120868
CASP3 GeneProduct ensembl:ENSG00000164305
CASP9 GeneProduct ensembl:ENSG00000132906
CCNE1 GeneProduct ensembl:ENSG00000105173 CCNE1; cyclin E
CCNE2 GeneProduct ensembl:ENSG00000175305 CCNE2; cyclin E
CDK2 GeneProduct ensembl:ENSG00000123374 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDK6 GeneProduct ensembl:ENSG00000105810 CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
RB1 GeneProduct ensembl:ENSG00000139687
CDK4 GeneProduct ensembl:ENSG00000135446 CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CCND1 GeneProduct ensembl:ENSG00000110092 CCND3; cyclin D3
E2F1 GeneProduct ensembl:ENSG00000101412 E2F1; E2F transcription factor 1
E2F2 GeneProduct ensembl:ENSG00000007968 E2F2; E2F transcription factor 2
E2F3 GeneProduct ensembl:ENSG00000112242 E2F3; E2F transcription factor 3
SKP1 GeneProduct ensembl:ENSG00000113558
CDKN1C GeneProduct ensembl:ENSG00000129757 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN1B GeneProduct ensembl:ENSG00000111276 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CKS2 GeneProduct ensembl:ENSG00000123975
MAX GeneProduct ensembl:ENSG00000125952
CDKN2B GeneProduct ensembl:ENSG00000147883
ZBTB17 GeneProduct ensembl:ENSG00000116809
LAMA1 GeneProduct ncbigene:284217
COL4A4 GeneProduct ncbigene:1286
LAMA2 GeneProduct ncbigene:3908
LAMA5 GeneProduct ncbigene:3911
LAMB1 GeneProduct ncbigene:3912
LAMC3 GeneProduct ncbigene:10319
LAMB2 GeneProduct ncbigene:3913
LAMA3 GeneProduct ncbigene:3909
COL4A2 GeneProduct ncbigene:1284
LAMA4 GeneProduct ncbigene:3910
LAMB3 GeneProduct ncbigene:3914
COL4A5 GeneProduct ensembl:ENSG00000188153
COL4A6 GeneProduct ncbigene:1288
LAMC1 GeneProduct ncbigene:3915
FN1 GeneProduct ncbigene:2335
LAMC2 GeneProduct ncbigene:3918
COL4A1 GeneProduct ncbigene:1282
COL4A3 GeneProduct ensembl:ENSG00000169031
LAMB4 GeneProduct ensembl:ENSG00000091128
ITGB1 GeneProduct ncbigene:3688
ITGA6 GeneProduct ncbigene:3655
ITGA2 GeneProduct ncbigene:3673
ITGA2B GeneProduct ncbigene:3674
ITGA3 GeneProduct ncbigene:3675
ITGAV GeneProduct ncbigene:3685
PIK3R1 GeneProduct ncbigene:5295
PTK2 GeneProduct ncbigene:5747 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
PIK3R3 GeneProduct ensembl:ENSG00000117461
PTEN GeneProduct ncbigene:5728
AKT2 GeneProduct ncbigene:208
PIK3R2 GeneProduct ncbigene:5296
PIK3CA GeneProduct ncbigene:5290
AKT1 GeneProduct ncbigene:207
PIK3CB GeneProduct ncbigene:5291
AKT3 GeneProduct ncbigene:10000
PIK3CD GeneProduct ncbigene:5293
IKBKG GeneProduct ensembl:ENSG00000269335
IKBKB GeneProduct ensembl:ENSG00000104365
CHUK GeneProduct ensembl:ENSG00000213341
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ensembl:ENSG00000173039
NFKBIA GeneProduct ensembl:ENSG00000100906
NFKBIB GeneProduct ensembl:ENSG00000104825
CCND1 GeneProduct ensembl:ENSG00000110092
BIRC2 GeneProduct ensembl:ENSG00000110330
BIRC3 GeneProduct ensembl:ENSG00000023445
BIRC7 GeneProduct ensembl:ENSG00000101197
BIRC8 GeneProduct ensembl:ENSG00000163098
BCL2L1 GeneProduct ensembl:ENSG00000171552
TRAF2 GeneProduct ensembl:ENSG00000127191
TRAF3 GeneProduct ensembl:ENSG00000131323
TRAF4 GeneProduct ensembl:ENSG00000076604
TRAF5 GeneProduct ensembl:ENSG00000082512
TRAF6 GeneProduct ensembl:ENSG00000175104
TRAF1 GeneProduct ensembl:ENSG00000056558
PTGS2 GeneProduct ensembl:ENSG00000073756
NOS2 GeneProduct ensembl:ENSG00000007171

References

  1. KEGG Pathway: map05222
  2. Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells. Deng WG, Nishizaki M, Fang B, Roth JA, Ji L. Biochem Biophys Res Commun. 2007 Apr 20;355(4):993–9. PubMed Europe PMC Scholia
  3. PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E. Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20. PubMed Europe PMC Scholia