Cholesterol metabolism (WP632)
Rattus norvegicus
Cholesterol is essential for life - it's a required for the regulation of membrane fluidity. Cholesterol also serves as a precursor for many other biochemical pathways. Cholesterol is synthesized throughout the body but mainly in liver, intestines, adrenal glands and reproductive organs. Synthesis starts with the combination of Acetyl-CoA and Acetoacetyl-CoA. An important intemediary in the synthesis of cholesterol is mevalonate. Synthesis of cholesterol is regulated by a homeostatic mechanism.
Authors
Susan Coort , I450472 , Kristina Hanspers , Martina Summer-Kutmon , Christine Chichester , and Egon WillighagenActivity
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Organisms
Rattus norvegicusCommunities
Annotations
Pathway Ontology
cholesterol metabolic pathway arterial occlusive disease pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| (S)-2,3-Epoxysqualene | Metabolite | hmdb:HMDB0001188 | |
| Isopentenyl pyrophosphate | Metabolite | hmdb:HMDB0001347 | |
| Lathosterol | Metabolite | hmdb:HMDB0001170 | |
| Dimethylallylpyrophosphate | Metabolite | hmdb:HMDB0001120 | |
| Mevalonate | Metabolite | hmdb:HMDB0000227 | |
| Squalene | Metabolite | hmdb:HMDB0000256 | |
| Lanosterin | Metabolite | hmdb:HMDB0001251 | |
| Acetoacetyl-CoA | Metabolite | hmdb:HMDB0001484 | |
| Mevalonate Pyrophosphat | Metabolite | hmdb:HMDB0001981 | |
| Cholesterol | Metabolite | hmdb:HMDB0000067 | |
| Geranyl pyrophosphate | Metabolite | hmdb:HMDB0001285 | |
| Dehydrocholesterol | Metabolite | hmdb:HMDB0000032 | |
| HMG-CoA | Metabolite | hmdb:HMDB0001375 | |
| Cholesterol ester | Metabolite | chebi:17002 | |
| Acetyl-CoA | Metabolite | hmdb:HMDB0001206 | |
| Farnesyl pyrophosphate | Metabolite | hmdb:HMDB0000961 | |
| Hmgcs1 | GeneProduct | ncbigene:29637 | |
| Soat1 | GeneProduct | ensembl:ENSRNOG00000004111 | |
| Scarb1 | GeneProduct | ensembl:ENSRNOG00000000981 | |
| Fdft1 | GeneProduct | ensembl:ENSRNOG00000021314 | |
| Hmgcr | GeneProduct | ncbigene:25675 | |
| Apoe | GeneProduct | ensembl:ENSRNOG00000018454 | |
| MVK | GeneProduct | ncbigene:81727 | |
| Dhcr7 | GeneProduct | ensembl:ENSRNOG00000020776 | |
| Srebf1 | GeneProduct | ensembl:ENSRNOG00000003463 | |
| Apoc2 | GeneProduct | ensembl:ENSRNOG00000018402 | |
| Lss | GeneProduct | ensembl:ENSRNOG00000054549 | |
| Fdps | GeneProduct | ncbigene:83791 | |
| Sqle | GeneProduct | ensembl:ENSRNOG00000009550 | |
| Ldlr | GeneProduct | ensembl:ENSRNOG00000009946 | |
| Lpl | GeneProduct | ensembl:ENSRNOG00000012181 | |
| Lipc | GeneProduct | ensembl:ENSRNOG00000060338 | |
| Apoc1 | GeneProduct | ensembl:ENSRNOG00000018426 | |
| Mvd | GeneProduct | ensembl:ENSRNOG00000013376 | |
| Nsdhl | GeneProduct | ensembl:ENSRNOG00000057814 | |
| Idi1 | GeneProduct | ensembl:ENSRNOG00000016690 | |
| Sc4mol | GeneProduct | ensembl:ENSRNOG00000032297 | |
| Lrp1 | GeneProduct | ncbigene:299858 | |
| Sc5d | GeneProduct | ensembl:ENSRNOG00000008305 |
References
- Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins. Gadbut AP, Wu L, Tang D, Papageorge A, Watson JA, Galper JB. EMBO J. 1997 Dec 15;16(24):7250–60. PubMed Europe PMC Scholia
- Improvement of Endothelial Function by HMG-CoA Reductase Inhibitors. Wassmann S, Nickenig G. Drug News Perspect. 2002 Mar;15(2):85–92. PubMed Europe PMC Scholia