Non-canonical Wnt pathway (WP215)

Danio rerio

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads

Authors

Gabby Krens , Kristina Hanspers , Daniela Digles , Alex Pico , Egon Willighagen , Denise Slenter , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

Wnt signaling, non-canonical pathway

Participants

Label Type Compact URI Comment
Ca2+ Metabolite chebi:29108
GBP GeneProduct ncbigene:30719
vangl2 GeneProduct ensembl:ENSDARG00000027397
vent GeneProduct ncbigene:64810
ntl GeneProduct ncbigene:30399
wnt11r GeneProduct ensembl:ENSDARG00000014796
wif1 GeneProduct ncbigene:30476 wnt inhibitory factor 1
cdc42l2 GeneProduct ncbigene:556226
camk1g GeneProduct ncbigene:335654
APC GeneProduct ncbigene:386762
cyclin D1 GeneProduct ncbigene:30222
abi1a GeneProduct ensembl:ENSDARG00000010155
fzd8a GeneProduct ncbigene:58073
cdc42 GeneProduct ncbigene:336839
wnt2 GeneProduct ncbigene:30127
rac2 GeneProduct ncbigene:415151
otx2 GeneProduct ncbigene:30501
fzd9 GeneProduct ncbigene:58023
wnt11 GeneProduct ensembl:ENSDARG00000004256 silberblick
rfzd8b GeneProduct ncbigene:58072
fzd3 GeneProduct ncbigene:30371
prkcbb GeneProduct ensembl:ENSDARG00000022254
tcf3 / tcf7l1a GeneProduct ncbigene:30523
cdc42l GeneProduct ensembl:ENSDARG00000040158
wnt10b GeneProduct ncbigene:30308
wnt7 GeneProduct ncbigene:60633
RhoAd GeneProduct ncbigene:436718
mapk10 GeneProduct ensembl:ENSDARG00000102730
daam1 GeneProduct ncbigene:378457
cdx4 GeneProduct ncbigene:30330
axin1 GeneProduct ncbigene:57931 masterblind
mapk8b GeneProduct ensembl:ENSDARG00000009870
ved GeneProduct ncbigene:368201
sqt GeneProduct ncbigene:30153
gelsolin GeneProduct ncbigene:321099
lef GeneProduct ncbigene:30701
rock2b GeneProduct ensembl:ENSDARG00000004877
sp5a GeneProduct ensembl:ENSDARG00000076571
wnt4b GeneProduct ncbigene:57928
rock2a GeneProduct ensembl:ENSDARG00000017500
actr3 GeneProduct ensembl:ENSDARG00000091138
fzd7b GeneProduct ncbigene:30412
wnt3l GeneProduct ncbigene:60632
tcl GeneProduct ncbigene:386615 secreted frizzled-related protein
ptpn11a GeneProduct ensembl:ENSDARG00000020334
NLK GeneProduct ncbigene:405892 Nem like kinase
mapk9 GeneProduct ensembl:ENSDARG00000077364
tcf3b / tcf7l1b GeneProduct ncbigene:30556
dvl3 GeneProduct ncbigene:80972 deshevelled3
cki GeneProduct ncbigene:30328
wnt8a GeneProduct ncbigene:30122
groucho1 GeneProduct ncbigene:30205
wnt16 GeneProduct ncbigene:404628
prickle1a GeneProduct ensembl:ENSDARG00000040649
LRP5 GeneProduct ncbigene:554087
chd GeneProduct ncbigene:30161
evlb GeneProduct ensembl:ENSDARG00000099720
has2 GeneProduct ensembl:ENSDARG00000036987
pfn2 GeneProduct ensembl:ENSDARG00000003952
groucho3 GeneProduct ncbigene:83411
cfl2 GeneProduct ensembl:ENSDARG00000014106
mkp3 GeneProduct ncbigene:353314
sfzd1 GeneProduct ncbigene:402843 secreted frizzled-related protein
wnt5a GeneProduct zfin:ZDB-GENE-060328-3
vangl1 GeneProduct ensembl:ENSDARG00000004305
prickle2 GeneProduct ncbigene:368250
wnt2b GeneProduct ncbigene:359837
eve1 GeneProduct ncbigene:30335
oep GeneProduct ncbigene:30304
csk GeneProduct ensembl:ENSDARG00000067996
dvl2 GeneProduct ncbigene:323630 deshevelled2
boz GeneProduct ncbigene:30170
fzd7a GeneProduct ensembl:ENSDARG00000060004
rhoca GeneProduct ensembl:ENSDARG00000021309
axin2 GeneProduct ncbigene:58080
vox GeneProduct ncbigene:64807
nap1l1 GeneProduct ensembl:ENSDARG00000101813
wnt1 GeneProduct ncbigene:30128
evla GeneProduct ensembl:ENSDARG00000035650
pfn2l GeneProduct ensembl:ENSDARG00000012682
gsc GeneProduct ncbigene:30212
fzd4 GeneProduct ncbigene:30363
pea GeneProduct ncbigene:30700
dvl2 GeneProduct ncbigene:323630
wnt8b GeneProduct ncbigene:30144
RhoAb GeneProduct ncbigene:336001
otx1 GeneProduct ncbigene:30500
camk2d GeneProduct ncbigene:436815
dharma/boz GeneProduct ncbigene:30170
bmp4 GeneProduct ncbigene:30612
rac3 GeneProduct ncbigene:437027
celsr1b GeneProduct ensembl:ENSDARG00000058259
knypek GeneProduct ncbigene:118437
c-myc GeneProduct ncbigene:30686
fgf8 GeneProduct ncbigene:30538
E12 / tcf3 GeneProduct ncbigene:30310
cap1 GeneProduct ensembl:ENSDARG00000016350
Tak1 GeneProduct ncbigene:553788
tbx6 GeneProduct ncbigene:30254
capgb GeneProduct ensembl:ENSDARG00000099672
pak1 GeneProduct ncbigene:373103
dia1 GeneProduct ncbigene:336553
fzd2 GeneProduct ncbigene:30370
dvl3 GeneProduct ncbigene:80972
ERK2 / MAPK1 GeneProduct ncbigene:360144
Yes1 GeneProduct ncbigene:407620
src GeneProduct ensembl:ENSDARG00000008107
tmsb4x GeneProduct ensembl:ENSDARG00000077777
fzd10 GeneProduct ncbigene:30366
rock1 GeneProduct ensembl:ENSDARG00000058993
wnt7a GeneProduct ncbigene:565714
rac1a GeneProduct ensembl:ENSDARG00000074849
capga GeneProduct ensembl:ENSDARG00000035560
quo GeneProduct ncbigene:321031
ERK1 / MAPK3 GeneProduct ncbigene:399480
erm GeneProduct ncbigene:30452
limk1 GeneProduct ncbigene:735292
celsr1a GeneProduct ensembl:ENSDARG00000069185
spry4 GeneProduct ncbigene:114437
smo GeneProduct ncbigene:30225
stat3 GeneProduct ncbigene:30767
c-jun GeneProduct ncbigene:335916
icat GeneProduct ncbigene:58117 beta-catenin-interacting protein
fyna GeneProduct ensembl:ENSDARG00000011370
fzd8c GeneProduct ncbigene:30364
lim1 GeneProduct ncbigene:30463
fzd10 GeneProduct ensembl:ENSDARG00000068213
cfl1 GeneProduct ensembl:ENSDARG00000021124
groucho2 GeneProduct ncbigene:30206
catenin-beta 2 GeneProduct ncbigene:324004 ’catenin (cadherin-associated protein), beta 2’
flh GeneProduct ncbigene:30260
mitfa GeneProduct ncbigene:30080
bmp2b GeneProduct ncbigene:30632
prickle1 GeneProduct ncbigene:368249
spry2 GeneProduct ncbigene:335098
gata2 GeneProduct ncbigene:30480
sfzd5 GeneProduct ncbigene:117510 secreted frizzled-related protein
gsk3b GeneProduct ncbigene:30654
catenin-beta 1 GeneProduct ncbigene:30265 ’catenin (cadherin-associated protein), beta 1 ’
rhoac GeneProduct ensembl:ENSDARG00000099709
wnt4a GeneProduct ncbigene:30123
wnt5b GeneProduct ncbigene:30105
tbx16 / spt GeneProduct ncbigene:30264
Sp5l GeneProduct ncbigene:324261
dact2 / drapper GeneProduct ncbigene:337795 ’dapper homolog 2, antagonist of beta-catenin’
actr2a GeneProduct ensembl:ENSDARG00000052438
fz12 GeneProduct ncbigene:30275
ephin B1 GeneProduct ncbigene:114377
frzb GeneProduct ncbigene:30119
wnt10a GeneProduct ncbigene:30171
limk2 GeneProduct ensembl:ENSDARG00000005104
RhoAa GeneProduct ncbigene:406411
fgf3 GeneProduct ncbigene:30549
tcf4 GeneProduct ncbigene:30510
rac1b GeneProduct ensembl:ENSDARG00000087954
rac1l GeneProduct ensembl:ENSDARG00000054649
actr2b GeneProduct ensembl:ENSDARG00000070076

References

  1. ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. Krens SFG, Corredor-Adámez M, He S, Snaar-Jagalska BE, Spaink HP. BMC Genomics. 2008 Apr 28;9:196. PubMed Europe PMC Scholia