Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins (WP4936)
Homo sapiens
Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2, derived from the network diffusion model and overlaid with the changes in protein levels, ubiquitination and phosphorylation induced by SARS-CoV-2 infection
Authors
Rex D A B , Egon Willighagen , Friederike Ehrhart , Marvin Martens , Eric Weitz , Finterly Hu , Kristina Hanspers , Martina Summer-Kutmon , and Nhung PhamActivity
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Organisms
Homo sapiensCommunities
COVID-19Annotations
Pathway Ontology
infectious disease pathway altered autophagy pathwayDisease Ontology
COVID-19| Label | Type | Compact URI | Comment |
|---|---|---|---|
| LARP1 | GeneProduct | ensembl:ENSG00000155506 | |
| PPP1R9A | GeneProduct | ensembl:ENSG00000158528 | Also known as NRB1 |
| MAP1LC3B | GeneProduct | ncbigene:81631 | |
| ATG4A | GeneProduct | ensembl:ENSG00000101844 | |
| P70S6K | GeneProduct | ensembl:ENSG00000108443 | |
| RB1CC1 | GeneProduct | ensembl:ENSG00000023287 | |
| VPS18 | GeneProduct | ensembl:ENSG00000104142 | |
| AKT1S1 | GeneProduct | ensembl:ENSG00000204673 | |
| orf3 | GeneProduct | uniprot:P0DTC3 | orf3 has no identifiers, but orf3a and orf3b do, and orf3a is the only one with enough amino acids to be structure in Figure 3 |
| VPS33A | GeneProduct | ensembl:ENSG00000139719 | |
| VPS39 | GeneProduct | ensembl:ENSG00000166887 | |
| orf3 | GeneProduct | uniprot:P0DTC3 | orf3 has no identifiers, but orf3a and orf3b do, and orf3a is the only one with enough amino acids to be structure in Figure 3 |
| EIF4B | GeneProduct | ensembl:ENSG00000063046 | |
| LAMP2 | GeneProduct | ensembl:ENSG00000005893 | |
| APOB | GeneProduct | ensembl:ENSG00000084674 | |
| NBR1 | GeneProduct | ensembl:ENSG00000188554 | |
| VAMP8 | GeneProduct | ensembl:ENSG00000118640 | |
| TMEM59 | GeneProduct | ensembl:ENSG00000116209 | |
| LAMTOR1 | GeneProduct | ensembl:ENSG00000149357 | |
| ATG2B | GeneProduct | ensembl:ENSG00000066739 | |
| orf3 | GeneProduct | uniprot:P0DTC3 | orf3 has no identifiers, but orf3a and orf3b do, and orf3a is the only one with enough amino acids to be structure in Figure 3 |
| MLST8 | Protein | ncbigene:64223 | |
| ATG5 | Protein | ncbigene:9474 | |
| VPS16 | Protein | ncbigene:64601 | |
| VPS11 | Protein | ncbigene:55823 | |
| ATG13 | Protein | ncbigene:9776 | |
| AMPK | Protein | ncbigene:5563 | |
| TAX1BP1 | Protein | ncbigene:8887 | |
| PKM | Protein | ncbigene:5315 | |
| SQSTM1 | Protein | ncbigene:8878 | |
| OPTN | Protein | ncbigene:10133 | |
| ATG7 | Protein | ncbigene:10533 | |
| RAB7A | Protein | ncbigene:7879 | |
| VPS41 | Protein | ncbigene:27072 | |
| CALCOCO2 | Protein | ncbigene:10241 | |
| GABARAPL2 | Protein | ncbigene:11345 | |
| MTOR | Protein | ncbigene:2475 | |
| ATG3 | Protein | ncbigene:64422 | |
| DEPTOR | Protein | ncbigene:64798 | |
| RPS6 | Protein | ncbigene:6194 | |
| ATG12 | Protein | ncbigene:9140 | |
| AKT1 | Protein | uniprot:P31749 | |
| ATG16L | Protein | ncbigene:55054 | |
| RHEB | Protein | ncbigene:6009 | |
| RPTOR | Protein | ncbigene:57521 | |
| ULK1 | Protein | ncbigene:8408 | |
| ATG9A | Protein | ncbigene:79065 | |
| GSK3 | Protein | ncbiprotein:P31749 | |
| TSC2 | Protein | ncbiprotein:P31749 | |
| nsp6 | Protein | ncbiprotein:YP_009725302 |
References
- Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C, et al. Nature. 2021 Jun;594(7862):246–52. PubMed Europe PMC Scholia