Metabolism of sphingolipids in ER and Golgi apparatus (WP4142)
Homo sapiens
New Pathway on Sphingolipids.
Authors
Denise Slenter , Egon Willighagen , Youssef Walid , Eric Weitz , Finterly Hu , and Daniela DiglesActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
lacto-series glycosphingolipid metabolic pathway glycosphingolipid metabolic pathway sphingolipid biosynthetic pathway sphingolipid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Neutral GSLs | Metabolite | chebi:25513 | neutral glycosphingolip = Any glycosphingolipid containing unsubstituted glycosyl moieties. |
| GT3 | Metabolite | chebi:28541 | ganglioside GT3 |
| GA2 | Metabolite | chebi:27731 | ganglioside GA2 |
| GD3 | Metabolite | chebi:89636 | Ganglioside GD3 |
| GM3 | Metabolite | chebi:15681 | ganglioside GM3 |
| Ethanolamine phosphate | Metabolite | wikidata:Q418826 | |
| Dihydroceramide | Metabolite | hmdb:HMDB0006752 | |
| Sphinganine | Metabolite | hmdb:HMDB0000269 | |
| 3-ketosphinganine | Metabolite | wikidata:Q27073739 | |
| Ceramide | Metabolite | chebi:17761 | |
| Hexadecanal | Metabolite | wikidata:Q27077978 | |
| Sphinganine 1-phosphate | Metabolite | wikidata:Q27077062 | |
| Sphingosine | Metabolite | wikidata:Q46298 | |
| Sphingosine-1-phosphate | Metabolite | wikidata:Q418267 | |
| Galactosyl-ceramide | Metabolite | wikidata:Q2756638 | Galactocerebroside |
| Ceramide-1-phosphate | Metabolite | wikidata:Q35664620 | Cer-1-P |
| Sphingomyelin | Metabolite | wikidata:Q423143 | |
| Glucosylceramide | Metabolite | wikidata:Q35662896 | |
| Sulfatide | Metabolite | wikidata:Q408584 | |
| Galactosylceramide | Metabolite | chebi:36498 | Gala-serie (=GalCer) GSLs (glycosphingolipids) |
| Lactosylceramide | Metabolite | wikidata:Q3215908 | |
| Serine | Metabolite | chebi:17822 | |
| Palmitoyl CoA | Metabolite | wikidata:Q3361645 | |
| Ceramide | Metabolite | chebi:17761 | |
| Galactosyl-ceramide | Metabolite | wikidata:Q2756638 | Galactocerebroside |
| DEGS2 | Metabolite | wikidata:Q21115762 | |
| DEGS1 | Metabolite | wikidata:Q21105760 | |
| Dihydroceramide desaturase | Metabolite | wikidata:Q17117943 | |
| GM2 | Metabolite | chebi:51013 | ganglioside GM2 |
| GM1a | Metabolite | chebi:18216 | ganglioside GM1a |
| GD1a | Metabolite | chebi:18163 | ganglioside GD1a |
| GD2 | Metabolite | chebi:28648 | ganglioside GD2 |
| GD1b | Metabolite | chebi:28175 | ganglioside GD1b |
| GT1b | Metabolite | chebi:28058 | ganglioside GT1b |
| GT2 | Metabolite | chebi:61732 | ganglioside GT2 |
| GT1c | Metabolite | chebi:87992 | ganglioside GT1c |
| GQ1c | Metabolite | chebi:87994 | ganglioside GQ1c |
| GA1 | Metabolite | chebi:27938 | ganglioside GA1 |
| GM1b | Metabolite | chebi:62370 | ganglioside GM1b |
| SPHK2 | Protein | ensembl:ENSG00000063176 | |
| SPHK1 | Protein | ensembl:ENSG00000176170 | |
| GalNacT | Protein | eccode:2.4.1.41 | N-acetylgalactosaminetransferase |
| Sphingosine kinase | Protein | eccode:2.7.1.91 | |
| SATI | Protein | eccode:2.4.99.9 | sialyltransferase SAT1 |
| B3GALNT1 | Protein | ensembl:ENSG00000169255 | |
| SPL1 | Protein | uniprot:O95470 | Sphingosine-1-phosphate lyase 1 |
| SPHK2 | Protein | ensembl:ENSG00000063176 | |
| SPHK1 | Protein | ensembl:ENSG00000176170 | |
| Sphingosine kinase | Protein | eccode:2.7.1.91 | |
| SPGG1 | Protein | uniprot:Q9BX95 | sphingosine-1-phosphate phosphatase |
| SPGG2 | Protein | uniprot:Q8IWX5 | sphingosine-1-phosphate phosphatase |
| SPGG1 | Protein | uniprot:Q9BX95 | sphingosine-1-phosphate phosphatase |
| SPGG2 | Protein | uniprot:Q8IWX5 | sphingosine-1-phosphate phosphatase |
| SPTLC1P1 | Protein | ncbigene:100874511 | serine palmitoyltransferase |
| SPTLC1P2 | Protein | ncbigene:100874498 | serine palmitoyltransferase |
| SPTLC1P3 | Protein | ncbigene:100874499 | serine palmitoyltransferase |
| SPTLC1P4 | Protein | ncbigene:100874500 | serine palmitoyltransferase |
| SPTLC1P5 | Protein | ncbigene:100874512 | serine palmitoyltransferase |
| KDSR | Protein | uniprot:Q06136 | 3-ketodihydrosphingosine reductase |
| CERS3 | Protein | uniprot:Q8IU89 | dihydroceramide synthase |
| GalCer synthase | Protein | uniprot:Q16880 | UGT8 / CGT |
| CERK | Protein | uniprot:Q8TCT0 | Ceramide Kinase |
| SGMS2 | Protein | uniprot:Q8NHU3 | Sphingomyelin synthase 2 |
| GlcCer synthase | Protein | uniprot:Q16739 | glucosylceramide synthase (GCS) |
| B3GALT1 | Protein | ensembl:ENSG00000172318 | |
| B4GALNT1 | Protein | ensembl:ENSG00000135454 | |
| B4GALT1 | Protein | ensembl:ENSG00000086062 | |
| GALNTL1 | Protein | uniprot:Q8N428 | GALNT16 Synonyms:GALNTL1 (uniprot) |
| GALNT1 | Protein | ensembl:ENSG00000141429 | |
| SPL1 | Protein | uniprot:O95470 | Sphingosine-1-phosphate lyase 1 |
| SATIV | Protein | eccode:2.4.99.10 | sialyltransferase SAT4 |
| GalNacT | Protein | eccode:2.4.1.41 | N-acetylgalactosaminetransferase |
| GalNacT | Protein | eccode:2.4.1.41 | N-acetylgalactosaminetransferase |
| GalNacT | Protein | eccode:2.4.1.41 | N-acetylgalactosaminetransferase |
| SATIV | Protein | eccode:2.4.99.10 | sialyltransferase SAT4 |
| SATIV | Protein | eccode:2.4.99.10 | sialyltransferase SAT4 |
| SATIV | Protein | eccode:2.4.99.10 | sialyltransferase SAT4 |
| SATII | Protein | eccode:2.4.99.8 | sialyltransferase SAT2 |
| SATIII | Protein | uniprot:Q8NDV1 | sialyltransferase SAT3 |
| B3GALT2 | Protein | uniprot:O43825 | GalTII = galactosyltransferase |
| B4GALT2 | Protein | uniprot:O60909 | GalTII = galactosyltransferase |
| B3GALT2 | Protein | uniprot:O43825 | GalTII = galactosyltransferase |
| B4GALT2 | Protein | uniprot:O60909 | GalTII = galactosyltransferase |
| B3GALT2 | Protein | uniprot:O43825 | GalTII = galactosyltransferase |
| B4GALT2 | Protein | uniprot:O60909 | GalTII = galactosyltransferase |
| B3GALT2 | Protein | uniprot:O43825 | GalTII = galactosyltransferase |
| B4GALT2 | Protein | uniprot:O60909 | GalTII = galactosyltransferase |
| SGMS1 | Protein | uniprot:Q86VZ5 | Sphingomyelin synthase 1 |
References
- The metabolism and function of sphingolipids and glycosphingolipids. Lahiri S, Futerman AH. Cell Mol Life Sci. 2007 Sep;64(17):2270–84. PubMed Europe PMC Scholia