Neural crest cell migration during development (WP4564)

Homo sapiens

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During normal neuronal development, neural crest cells participate in migration and invasion processes. The growth factor BDNF binds to and activates NGFR (p75NTR) in various contexts, invoking signaling pathways that lead to transcriptional activation in the nucleus. Also see the closely related pathway, "Neural crest cells in cancer" ([https://www.wikipathways.org/index.php/Pathway:WP4565 WP4565]).

Authors

Alex Pico and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway brain-derived neurotrophic factor signaling pathway

Cell Type Ontology

migratory neural crest cell

Participants
Query Drugst.One

Label Type Compact URI Comment
AKT2 GeneProduct ncbigene:208 AKT
AKT3 GeneProduct ncbigene:10000 AKT
CDH11 GeneProduct ncbigene:1009 Cadherin
NGEF GeneProduct ncbigene:25791
FOS GeneProduct ncbigene:2353 AP-1
EPHB1 GeneProduct ncbigene:2047 MMP
MMP9 GeneProduct ncbigene:4318 MMP
MMP2 GeneProduct ncbigene:4313 MMP2
PIK3CA GeneProduct ncbigene:5290 PI3K
PIK3CB GeneProduct ncbigene:5291 PI3K
PIK3CD GeneProduct ncbigene:5293 PI3K
PIK3R3 GeneProduct ncbigene:8503 PI3K
PIK3R4 GeneProduct ncbigene:30849 PI3K
PIK3R5 GeneProduct ncbigene:23533 PI3K
PIK3R6 GeneProduct ncbigene:146850 PI3K
TIAM1 GeneProduct ncbigene:7074 Tiam
TRIO GeneProduct ncbigene:7204 TRIO
MMP8 GeneProduct ncbigene:4317 MMP
TWIST1 GeneProduct ncbigene:7291 Twist1,
PIK3CG GeneProduct ncbigene:5294 PI3K
ARF1 GeneProduct ncbigene:375
RAC1 GeneProduct ncbigene:5879 MMP
PAK1 GeneProduct ncbigene:5058
AKT1 GeneProduct ncbigene:207 AKT
BDNF GeneProduct ncbigene:627 BDNF
F2RL2 GeneProduct ncbigene:2151 MMP
JUN GeneProduct ncbigene:3725 JUN/AP
RHOA GeneProduct ncbigene:387 RhoA
STAT3 GeneProduct ncbigene:6774 STAT3
CDH11 GeneProduct ncbigene:1009 Cadherin
AKT3 GeneProduct ncbigene:10000 AKT
AKT1 GeneProduct ncbigene:207 AKT
AKT2 GeneProduct ncbigene:208 AKT
NGFR GeneProduct ncbigene:4804 MMP2
NGFR GeneProduct ncbigene:4804 p75(NTR)
EPHB2 GeneProduct ncbigene:2048 MMP
EPHB3 GeneProduct ncbigene:2049 MMP
EPHB4 GeneProduct ncbigene:2050 MMP
EPHB6 GeneProduct ncbigene:2051 MMP
BDNF GeneProduct ncbigene:627 BDNF
STAT3 GeneProduct ncbigene:6774 STAT3
MMP2 GeneProduct ncbigene:4313 MMP2
TWIST1 GeneProduct ncbigene:7291 Twist1,
MMP9 GeneProduct ncbigene:4318 MMP
RAC1 GeneProduct ncbigene:5879
PAK2 GeneProduct ncbigene:5062
PAK3 GeneProduct ncbigene:5063
PAK4 GeneProduct ncbigene:10298
PAK5 GeneProduct ncbigene:57144
PAK6 GeneProduct ncbigene:56924

References

  1. From Neural Crest Development to Cancer and Vice Versa: How p75NTR and (Pro)neurotrophins Could Act on Cell Migration and Invasion? Wislet S, Vandervelden G, Rogister B. Front Mol Neurosci. 2018 Aug 23;11:244. PubMed Europe PMC Scholia