SARS coronavirus and innate immunity (WP4912)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
SARS-CoV triggers the hosts innate immune system via the type I interferon system in dendritic cells and macrophages, which activate ISRE and IFN-b sentitive promoter elements.

Authors

Friederike Ehrhart , Egon Willighagen , Lauren J. Dupuis , John Figueira Hasbun , Eric Weitz , and Aishwarya Iyer

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

COVID-19

Annotations

Pathway Ontology

type I interferon signaling pathway

Disease Ontology

Coronavirus infectious disease severe acute respiratory syndrome viral infectious disease

Participants
Query Drugst.One

Label Type Compact URI Comment
IFNA21 GeneProduct ensembl:ENSG00000137080
IFNA10 GeneProduct ensembl:ENSG00000186803
STAT1 GeneProduct ensembl:ENSG00000115415
STAT2 GeneProduct ensembl:ENSG00000170581
IRF9 GeneProduct ensembl:ENSG00000213928
IKBKE GeneProduct ensembl:ENSG00000263528 IKK-e
TBK1 GeneProduct ensembl:ENSG00000183735
TRAF3 GeneProduct ensembl:ENSG00000131323
IFNA17 GeneProduct ensembl:ENSG00000234829
IFNA13 GeneProduct ensembl:ENSG00000233816
IFNA6 GeneProduct ensembl:ENSG00000120235
IFNA16 GeneProduct ensembl:ENSG00000147885
IFNAR2 GeneProduct ncbigene:3455
IFNA2 GeneProduct ensembl:ENSG00000188379
IFNA7 GeneProduct ensembl:ENSG00000214042
IFIH1 GeneProduct ensembl:ENSG00000115267 MDA5
TYK2 GeneProduct ensembl:ENSG00000105397
MAVS GeneProduct ensembl:ENSG00000088888
IFNA8 GeneProduct ensembl:ENSG00000120242
IFNB1 GeneProduct ensembl:ENSG00000171855
IFNA1 GeneProduct ensembl:ENSG00000197919
IRF3 GeneProduct ensembl:ENSG00000126456
IFNA14 GeneProduct ensembl:ENSG00000228083
IFNA4 GeneProduct ensembl:ENSG00000236637
IFNAR1 GeneProduct ncbigene:3454
TLR3 GeneProduct ensembl:ENSG00000164342
DDX58 GeneProduct ensembl:ENSG00000107201 RIG-I
ACE2 GeneProduct ensembl:ENSG00000130234
TICAM1 GeneProduct ncbigene:148022 TRIF
JAK1 GeneProduct ensembl:ENSG00000162434
IFNA5 GeneProduct ensembl:ENSG00000147873
S Protein uniprot:P0DTC2

References

  1. Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3. Spiegel M, Pichlmair A, Martínez-Sobrido L, Cros J, García-Sastre A, Haller O, et al. J Virol. 2005 Feb;79(4):2079–86. PubMed Europe PMC Scholia
  2. SARS coronavirus and innate immunity. Frieman M, Heise M, Baric R. Virus Res. 2008 Apr;133(1):101–12. PubMed Europe PMC Scholia