Fibrin complement receptor 3 signaling pathway (WP5128)

Mus musculus

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For a description of pathway objects, see the WikiPathways Legend.

Authors

Kristina Hanspers and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Cell Type Ontology

microglial cell macrophage

Pathway Ontology

classical complement pathway inflammatory response pathway coagulation cascade pathway

Participants

Label Type Compact URI Comment
LPS Metabolite chebi:16412
Fibrin Metabolite chebi:5054
Akt1 GeneProduct ensembl:ENSMUSG00000001729
Il6 GeneProduct ensembl:ENSMUSG00000025746
Ikbkb GeneProduct ensembl:ENSMUSG00000031537
Pik3ca GeneProduct ensembl:ENSMUSG00000027665
Plasminogen GeneProduct ensembl:ENSMUSG00000059481
Nfkb1 GeneProduct ensembl:ENSMUSG00000028163
Syk GeneProduct ensembl:ENSMUSG00000021457
Rel GeneProduct ensembl:ENSMUSG00000020275
Tlr3 GeneProduct ensembl:ENSMUSG00000031639
Cbl-b GeneProduct ensembl:ENSMUSG00000022637
Myd88 GeneProduct ensembl:ENSMUSG00000032508
Ifnb1 GeneProduct ensembl:ENSMUSG00000048806
Rhoa GeneProduct ensembl:ENSMUSG00000007815
Irak1 GeneProduct ensembl:ENSMUSG00000031392
tPa GeneProduct ensembl:ENSMUSG00000031538
Cxcl10 GeneProduct ensembl:ENSMUSG00000034855
Rapl GeneProduct ensembl:ENSMUSG00000026430
Tirap GeneProduct ensembl:ENSMUSG00000032041
Traf6 GeneProduct ensembl:ENSMUSG00000027164
TRIF GeneProduct ensembl:ENSMUSG00000047123
Cd14 GeneProduct ensembl:ENSMUSG00000051439
Dap12 GeneProduct ensembl:ENSMUSG00000030579
FcRg GeneProduct ensembl:ENSMUSG00000058715
Cxcl3 GeneProduct ensembl:ENSMUSG00000029379
Plasmin GeneProduct ensembl:ENSMUSG00000059481
Irak4 GeneProduct ensembl:ENSMUSG00000059883
MD2 GeneProduct ensembl:ENSMUSG00000025779
Lbp GeneProduct ensembl:ENSMUSG00000016024
Tlr4 GeneProduct ensembl:ENSMUSG00000039005
Src GeneProduct ensembl:ENSMUSG00000027646
TRAM GeneProduct ensembl:ENSMUSG00000056130
Irf3 GeneProduct ensembl:ENSMUSG00000003184
Cd11b GeneProduct ensembl:ENSMUSG00000030786
Cd18 GeneProduct ensembl:ENSMUSG00000000290
Tnf GeneProduct ensembl:ENSMUSG00000024401
Ccl2 GeneProduct ensembl:ENSMUSG00000035385
Chuk GeneProduct ensembl:ENSMUSG00000025199
Ikbkg GeneProduct ensembl:ENSMUSG00000004221
Fga GeneProduct ensembl:ENSMUSG00000028001
Irak2 GeneProduct ensembl:ENSMUSG00000060477
Il12b GeneProduct ensembl:ENSMUSG00000004296
Nos2 GeneProduct ensembl:ENSMUSG00000020826
Fgb GeneProduct ensembl:ENSMUSG00000033831
Fgg GeneProduct ensembl:ENSMUSG00000033860
Rela GeneProduct ensembl:ENSMUSG00000024927

References

  1. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. Caron E, Hall A. Science. 1998 Nov 27;282(5394):1717–21. PubMed Europe PMC Scholia
  2. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, et al. Science. 1998 Dec 11;282(5396):2085–8. PubMed Europe PMC Scholia
  3. Roles of PI3Ks in leukocyte chemotaxis and phagocytosis. Stephens L, Ellson C, Hawkins P. Curr Opin Cell Biol. 2002 Apr;14(2):203–13. PubMed Europe PMC Scholia
  4. Sequence gamma 377-395(P2), but not gamma 190-202(P1), is the binding site for the alpha MI-domain of integrin alpha M beta 2 in the gamma C-domain of fibrinogen. Ugarova TP, Lishko VK, Podolnikova NP, Okumura N, Merkulov SM, Yakubenko VP, et al. Biochemistry. 2003 Aug 12;42(31):9365–73. PubMed Europe PMC Scholia
  5. Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo. Flick MJ, Du X, Witte DP, Jirousková M, Soloviev DA, Busuttil SJ, et al. J Clin Invest. 2004 Jun;113(11):1596–606. PubMed Europe PMC Scholia
  6. The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. Adams RA, Bauer J, Flick MJ, Sikorski SL, Nuriel T, Lassmann H, et al. J Exp Med. 2007 Mar 19;204(3):571–82. PubMed Europe PMC Scholia
  7. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Park BS, Song DH, Kim HM, Choi BS, Lee H, Lee JO. Nature. 2009 Apr 30;458(7242):1191–5. PubMed Europe PMC Scholia
  8. Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Han C, Jin J, Xu S, Liu H, Li N, Cao X. Nat Immunol. 2010 Aug;11(8):734–42. PubMed Europe PMC Scholia
  9. Integrins limit the Toll. Means TK, Luster AD. Nat Immunol. 2010 Aug;11(8):691–3. PubMed Europe PMC Scholia
  10. Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, et al. Nat Commun. 2015 Sep 10;6:8164. PubMed Europe PMC Scholia