EDA signaling in hair follicle development (WP3930)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
EDA protein regulation of hair follicle growth and differentiation through activation Nf-kB pathway occurring by binding of p65/p50 complex. The new protein complex of Nf-kB/p65/p50 activates Wnt and Bmp pathway inhibitors stopping induction/patterning. Nf-kB complex then binds with Ltb and Shh to activate pathways for growth and differentiation. This pathway is based on figure 4 from Cui et al.

Authors

Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway nuclear factor kappa B signaling pathway altered nuclear factor kappa B signaling pathway

Cell Type Ontology

hair follicle cell

Participants
Query Drugst.One

Label Type Compact URI Comment
EDAR GeneProduct ensembl:ENSG00000135960 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003227
EDARADD GeneProduct ensembl:ENSG00000186197 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000095105
DKK4 GeneProduct ensembl:ENSG00000104371 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031535
DKK1 GeneProduct ensembl:ENSG00000107984 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024868
BMP1 GeneProduct ensembl:ENSG00000168487 BMP Not Specified
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022098
SOSTDC1 GeneProduct ensembl:ENSG00000171243 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036169
SHH GeneProduct ensembl:ENSG00000164690 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002633
GLI1 GeneProduct ensembl:ENSG00000111087 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025407
PTCH1 GeneProduct ensembl:ENSG00000185920 Ptc Not Specified
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021466
LTB GeneProduct ensembl:ENSG00000227507 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024399
RELB GeneProduct ensembl:ENSG00000104856 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002983
EDA Protein ensembl:ENSG00000158813 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q3UV69
EDA Protein ensembl:ENSG00000158813 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q1L2D9
WNT3 Protein ensembl:ENSG00000108379 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:A2A649

References

  1. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Cui CY, Hashimoto T, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9142–7. PubMed Europe PMC Scholia