Common pathways underlying drug addiction (WP2636)

Homo sapiens

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The pathway was modeled after Figure 2 in Li, et al. 2008 and is based on the common pathways identified in their study as well as protein interaction data. Specifically, glutamate and dopamine neuroactive ligand-receptor interactions trigger long-term potentiation, MAPK and GnRH signaling and gap junction regulation (green outlined pathway nodes). Related functional modules such as depolarization, gene expression and cytoskeleton regulation are also indicated (non-outlined pathway nodes). Among the several positive feedback loops identified in this pathway, the authors highlighted fast and slow ones in red and blue, respectively. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2636 CPTAC Assay Portal]

Authors

Andra Waagmeester , Egon Willighagen , Kristina Hanspers , Alex Pico , Denise Slenter , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Diseases

Annotations

Pathway Ontology

amphetamine addiction pathway drug pathway cocaine addiction pathway nicotine addiction pathway disease pathway morphine addiction pathway

Disease Ontology

alcohol dependence

Participants
Query Drugst.One

Label Type Compact URI Comment
cAMP Metabolite chemspider:5851
Dopamine Metabolite chemspider:661
Glutamate Metabolite wikidata:Q181136
Ca++ Metabolite chemspider:266
PRKACG GeneProduct ensembl:ENSG00000165059
ADCY1 GeneProduct ensembl:ENSG00000164742
CREB1 GeneProduct ensembl:ENSG00000118260
Connexin 32 GeneProduct ensembl:ENSG00000169562
GRIN1 GeneProduct ensembl:ENSG00000176884
PRKCA GeneProduct ensembl:ENSG00000154229
ERK1 GeneProduct ensembl:ENSG00000102882
CaM GeneProduct ensembl:ENSG00000198668
GRM1 GeneProduct ensembl:ENSG00000152822
DRD4 GeneProduct ensembl:ENSG00000069696
ACTB GeneProduct ensembl:ENSG00000075624
MEK1 GeneProduct ensembl:ENSG00000169032
CAMK2A GeneProduct ensembl:ENSG00000070808
CAMK4 GeneProduct ensembl:ENSG00000152495
DRD1 GeneProduct ensembl:ENSG00000184845
Gs GeneProduct ensembl:ENSG00000087460
GRIA1 GeneProduct ensembl:ENSG00000155511
Inhibitor-1 GeneProduct ensembl:ENSG00000135447
DRD2 GeneProduct ensembl:ENSG00000149295
MEK2 GeneProduct ensembl:ENSG00000126934
Gi GeneProduct ensembl:ENSG00000127955
ERK2 GeneProduct ensembl:ENSG00000100030
ACTG1 GeneProduct ensembl:ENSG00000184009
ACTG2 GeneProduct ensembl:ENSG00000163017
ADCY8 GeneProduct ensembl:ENSG00000155897
GRIA2 GeneProduct ensembl:ENSG00000120251
GRIA3 GeneProduct ensembl:ENSG00000125675
GRIA4 GeneProduct ensembl:ENSG00000152578
GRIN2A GeneProduct ensembl:ENSG00000183454
GRM5 GeneProduct ensembl:ENSG00000168959
PRKCB GeneProduct ensembl:ENSG00000166501
PRKCG GeneProduct ensembl:ENSG00000126583
PRKACA GeneProduct ensembl:ENSG00000072062
PRKACB GeneProduct ensembl:ENSG00000142875
PPP1CA GeneProduct ensembl:ENSG00000172531
PPP1CB GeneProduct ensembl:ENSG00000213639
PPP1CC GeneProduct ensembl:ENSG00000186298
RAF1 GeneProduct ensembl:ENSG00000132155
ARAF GeneProduct ensembl:ENSG00000078061
RAP1B GeneProduct ensembl:ENSG00000127314
RAP1A GeneProduct ensembl:ENSG00000116473

References

  1. Genes and (common) pathways underlying drug addiction. Li CY, Mao X, Wei L. PLoS Comput Biol. 2008 Jan;4(1):e2. PubMed Europe PMC Scholia