Ascaroside biosynthesis (WP2224)

Caenorhabditis elegans

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A proposed role of peroxisomal beta-oxidation enzymes in ascaroside biosynthesis in C. elegans. Ascarosides are small-molecule pheromones that play a role in dauer formation, mating attraction, and social feeding behaviors.

Authors

Karen Yook , Christine Chichester , Martina Summer-Kutmon , Alex Pico , Eric Weitz , and Egon Willighagen

Activity

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Cited In

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Organisms

Caenorhabditis elegans

Communities

Annotations

Pathway Ontology

ascaroside biosynthetic pathway lipid metabolic pathway

Participants

Label Type Compact URI Comment
acox-1 GeneProduct ensembl:WBGene00008564
MAOC-1 GeneProduct ensembl:WBGene00017123
DHS-28 GeneProduct ensembl:WBGene00000991
DAF-22 GeneProduct ensembl:WBGene00013284

References

  1. Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegans. von Reuss SH, Bose N, Srinivasan J, Yim JJ, Judkins JC, Sternberg PW, et al. J Am Chem Soc. 2012 Jan 25;134(3):1817–24. PubMed Europe PMC Scholia