Regulation of actin cytoskeleton (WP51)

Homo sapiens

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A cytoskeleton is a complex, dynamic network of interlinking protein filaments that extends from the cell nucleus to the cell membrane. Actin filaments, composed of the abundant actin protein, are a main component of the cytoskeleton, playing a key role muscle contraction. http://www.genome.jp/kegg/pathway/hsa/hsa04810.html Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP51 CPTAC Assay Portal]

Authors

Alex Pico , Kristina Hanspers , Diana Garcia , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , Zahra Roudbari , Finterly Hu , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

regulatory pathway cell adhesion signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
PIP2 Metabolite kegg.compound:C04637
Bradykinin Metabolite cas:58-82-2
Acetylcholine Metabolite cas:51-84-3
LPS Metabolite kegg.compound:C00338
PIP3 Metabolite kegg.compound:C05981
DIAP3 GeneProduct ncbigene:81624
PIP5K2B GeneProduct ncbigene:8396
MAPK1 GeneProduct ncbigene:5594
C3orf10 GeneProduct ncbigene:55845
CHRM3 GeneProduct ncbigene:1131
PIP5K1B GeneProduct ncbigene:8395
GSN GeneProduct ncbigene:2934
SSH1 GeneProduct ncbigene:54434
PAK1 GeneProduct ncbigene:5058
PFN1 GeneProduct ncbigene:5216
PIK3C3 GeneProduct ncbigene:5289
FGF5 GeneProduct ncbigene:2250
PDGFA GeneProduct ncbigene:5154
FGD1 GeneProduct ncbigene:2245
PIK3R5 GeneProduct ncbigene:23533
RAC1P4 GeneProduct ncbigene:286472
SOS2 GeneProduct ncbigene:6655
BAIAP2 GeneProduct ncbigene:10458
IQGAP1 GeneProduct ncbigene:8826
VCL GeneProduct ncbigene:7414
FGF10 GeneProduct ncbigene:2255
ARHGEF1 GeneProduct ncbigene:9138
ARHGEF7 GeneProduct ncbigene:8874
GNA13 GeneProduct ncbigene:10672
RDX GeneProduct ncbigene:5962
MYH10 GeneProduct ncbigene:4628
ABI2 GeneProduct ncbigene:10152
CHRM2 GeneProduct ncbigene:1129
CHRM1 GeneProduct ncbigene:1128
Pik3c2b GeneProduct ncbigene:5287
FGF9 GeneProduct ncbigene:2254
EGFR GeneProduct ncbigene:1956
ENAH GeneProduct ncbigene:55740
SSH2 GeneProduct ncbigene:85464
GRLF1 GeneProduct ncbigene:2909
RAC3 GeneProduct ncbigene:5881
WASF2 GeneProduct ncbigene:10163
PAK7 GeneProduct ncbigene:57144
PIP5KL1 GeneProduct ncbigene:138429
MRAS GeneProduct ncbigene:22808
MAP2K1 GeneProduct ncbigene:5604
LIMK1 GeneProduct ncbigene:3984
BDKRB1 GeneProduct ncbigene:623
FGF7 GeneProduct ncbigene:2252
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GNA12 GeneProduct ncbigene:2768
NCKAP1 GeneProduct ncbigene:10787
FGF14 GeneProduct ncbigene:2259
ACTB GeneProduct ncbigene:60
PIK3R2 GeneProduct ncbigene:5296
RAC1P2 GeneProduct ncbigene:442775
PAK2 GeneProduct ncbigene:5062
FGFR4 GeneProduct ncbigene:2264
FGF3 GeneProduct ncbigene:2248
CHRM5 GeneProduct ncbigene:1133
FGF12 GeneProduct ncbigene:2257
CDC42 GeneProduct ncbigene:998
TMSB4X GeneProduct ncbigene:7114
PIK3C2G GeneProduct ncbigene:5288
EGF GeneProduct ncbigene:1950
ARHGEF4 GeneProduct ncbigene:50649
BCAR1 GeneProduct ncbigene:9564
MYLK GeneProduct ncbigene:4638
SSH3 GeneProduct ncbigene:54961
FGF4 GeneProduct ncbigene:2249
PIK3R1 GeneProduct ncbigene:5295
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DOCK1 GeneProduct ncbigene:1793
CHRM4 GeneProduct ncbigene:1132
CFL2 GeneProduct ncbigene:1073
CD14 GeneProduct ncbigene:929
PDGFRB GeneProduct ncbigene:5159
ARPC5 GeneProduct ncbigene:10092
PIK3CA GeneProduct ncbigene:5290
PTK2 GeneProduct ncbigene:5747
FGF20 GeneProduct ncbigene:26281
FGF17 GeneProduct ncbigene:8822
RHOA GeneProduct ncbigene:387
SLC9A1 GeneProduct ncbigene:6548
FGFR3 GeneProduct ncbigene:2261
PIK3C2A GeneProduct ncbigene:5286
FGF23 GeneProduct ncbigene:8074
PIK3CB GeneProduct ncbigene:5291
BDKRB2 GeneProduct ncbigene:624
ROCK2 GeneProduct ncbigene:9475
FGF15/19 GeneProduct ncbigene:9965
FGF18 GeneProduct ncbigene:8817
PIP5K2A GeneProduct ncbigene:5305
FGF21 GeneProduct ncbigene:26291
NRAS GeneProduct ncbigene:4893
FGF2 GeneProduct ncbigene:2247
PIK3R3 GeneProduct ncbigene:8503
VIL2 GeneProduct ncbigene:7430
ROCK1 GeneProduct ncbigene:6093
ACTG1 GeneProduct ncbigene:71
FGF22 GeneProduct ncbigene:27006
FN1 GeneProduct ncbigene:2335
FGF16 GeneProduct ncbigene:8823
PIK3CG GeneProduct ncbigene:5294
ARHGEF6 GeneProduct ncbigene:9459
MYL1 GeneProduct ncbigene:4632
RAC1 GeneProduct ncbigene:5879
BRAF GeneProduct ncbigene:673
PPP1R12A GeneProduct ncbigene:4659
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RRAS2 GeneProduct ncbigene:22800
PIK3R4 GeneProduct ncbigene:30849
RRAS GeneProduct ncbigene:6237
APC GeneProduct ncbigene:324
C11orf13 GeneProduct ncbigene:8045
PDGFRA GeneProduct ncbigene:5156
KRAS GeneProduct ncbigene:3845
FGF13 GeneProduct ncbigene:2258
PIP5K1A GeneProduct ncbigene:8394
WASF1 GeneProduct ncbigene:8936
PAK4 GeneProduct ncbigene:10298
ACTN1 GeneProduct ncbigene:87
GNG12 GeneProduct ncbigene:55970
DIAP1 GeneProduct ncbigene:1729
PIP5K1C GeneProduct ncbigene:23396
SOS1 GeneProduct ncbigene:6654
MSN GeneProduct ncbigene:4478
CRK GeneProduct ncbigene:1398
ITGA1 GeneProduct ncbigene:3672
RAF1 GeneProduct ncbigene:5894
CSK GeneProduct ncbigene:1445
PIP5K2C GeneProduct ncbigene:79837
MAPK3 GeneProduct ncbigene:5595
PDGFB GeneProduct ncbigene:5155
CYFIP2 GeneProduct ncbigene:26999
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MAP2K2 GeneProduct ncbigene:5605
PXN GeneProduct ncbigene:5829
RAC2 GeneProduct ncbigene:5880
FGFR2 GeneProduct ncbigene:2263
PIK3CD GeneProduct ncbigene:5293
MAPK6 GeneProduct ncbigene:5597
PAK6 GeneProduct ncbigene:56924
Apc2 GeneProduct ncbigene:10297
GIT1 GeneProduct ncbigene:28964
CFL1 GeneProduct ncbigene:1072
MOS GeneProduct ncbigene:4342
FGF6 GeneProduct ncbigene:2251
FGF1 GeneProduct ncbigene:2246
F2 GeneProduct ncbigene:2147
F2R GeneProduct ncbigene:2149
FGFR1 GeneProduct ncbigene:2260
FGF11 GeneProduct ncbigene:2256
FGF8 GeneProduct ncbigene:2253
VAV1 GeneProduct ncbigene:7409
MAPK4 GeneProduct ncbigene:5596

References

  1. Cell adhesion and Rho small GTPases. Fukata M, Nakagawa M, Kuroda S, Kaibuchi K. J Cell Sci. 1999 Dec;112 ( Pt 24):4491–500. PubMed Europe PMC Scholia
  2. Rho GTPases: signaling, migration, and invasion. Schmitz AA, Govek EE, Böttner B, Van Aelst L. Exp Cell Res. 2000 Nov 25;261(1):1–12. PubMed Europe PMC Scholia
  3. Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. Sastry SK, Burridge K. Exp Cell Res. 2000 Nov 25;261(1):25–36. PubMed Europe PMC Scholia
  4. Small GTP-binding proteins. Takai Y, Sasaki T, Matozaki T. Physiol Rev. 2001 Jan;81(1):153–208. PubMed Europe PMC Scholia
  5. The cytoskeleton, cellular motility and the reductionist agenda. Pollard TD. Nature. 2003 Apr 17;422(6933):741–5. PubMed Europe PMC Scholia
  6. Cell migration: integrating signals from front to back. Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, et al. Science. 2003 Dec 5;302(5651):1704–9. PubMed Europe PMC Scholia
  7. Rho and Rac take center stage. Burridge K, Wennerberg K. Cell. 2004 Jan 23;116(2):167–79. PubMed Europe PMC Scholia