Regulation of actin cytoskeleton (WP51)

Homo sapiens

Authors

Alex Pico , Kristina Hanspers , Diana Garcia , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , Zahra Roudbari , Finterly Hu , and Eric Weitz

Activity

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Cited In

• Altered Levels of Proteins and Phosphoproteins, in the Absence of Early Causative Transcriptional Changes, Shape the Molecular Pathogenesis in the Brain of Young Presymptomatic Ki91 SCA3/MJD Mouse (2019).
• New Insight Into Mechanisms of Hepatic Encephalopathy: An Integrative Analysis Approach to Identify Molecular Markers and Therapeutic Targets.
• Non-dialyzable uremic toxins and renal tubular cell damage in CKD patients: a systems biology approach (2024).
• PTMNavigator: interactive visualization of differentially regulated post-translational modifications in cellular signaling pathways (2025).
• Proteomic signatures of acquired letrozole resistance in breast cancer: suppressed estrogen signaling and increased cell motility and invasiveness (2013).
• Proteomics analysis of the non-muscle myosin heavy chain IIa-enriched actin-myosin complex reveals multiple functions within the podocyte (2014).
• Unstable genomes elevate transcriptome dynamics (2014).
• Proteomics Analysis of Porcine Endometrial Cell-Derived Extracellular Vesicles Involved in Embryo Attachment (2025).
• Identification of potential mutations and genomic alterations in the epithelial and spindle cell components of biphasic synovial sarcomas using a human exome SNP chip (2015).

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Organisms

Homo sapiens

Communities

ONTOX

Annotations

Pathway Ontology

cell adhesion signaling pathway regulatory pathway

References

1. Cell adhesion and Rho small GTPases. Fukata M, Nakagawa M, Kuroda S, Kaibuchi K. J Cell Sci. 1999 Dec;112 ( Pt 24):4491–500. PubMed Europe PMC Scholia
2. Rho GTPases: signaling, migration, and invasion. Schmitz AA, Govek EE, Böttner B, Van Aelst L. Exp Cell Res. 2000 Nov 25;261(1):1–12. PubMed Europe PMC Scholia
3. Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. Sastry SK, Burridge K. Exp Cell Res. 2000 Nov 25;261(1):25–36. PubMed Europe PMC Scholia
4. Small GTP-binding proteins. Takai Y, Sasaki T, Matozaki T. Physiol Rev. 2001 Jan;81(1):153–208. PubMed Europe PMC Scholia
5. The cytoskeleton, cellular motility and the reductionist agenda. Pollard TD. Nature. 2003 Apr 17;422(6933):741–5. PubMed Europe PMC Scholia
6. Cell migration: integrating signals from front to back. Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, et al. Science. 2003 Dec 5;302(5651):1704–9. PubMed Europe PMC Scholia
7. Rho and Rac take center stage. Burridge K, Wennerberg K. Cell. 2004 Jan 23;116(2):167–79. PubMed Europe PMC Scholia