Glucose-1-phosphate metabolism (WP260)
Saccharomyces cerevisiae
Glycogen, a branched polymer of glucose, is a storage molecule whose accumulation is under rigorous control in many cells. In Saccharomyces cerevisiae, glycogen biosynthesis involves three processes: nucleation, elongation, and branching (also known as ramification). The formation of glycogen begins when either Glg1p or Glg2p uses UDP-glucose to self-glucosylate to produce a short alpha (1,4)-glucosyl chain covalently attached to one of their internal tyrosine residues. After the self-glucosylation of Glg1p or Glg2p, glycogen synthase is able to extend the linear alpha (1,4)-glucosyl chains of glycogen by catalyzing the formation of alpha (1,4)-glucosidic bonds from UDP- glucose at the non-reducing ends. Branches can be added into the glycogen molecule by Glc3p, which is the glycogen branching enzyme (EC:2.4.1.18) in S. cerevisiae.
Authors
Jessica Heckman , Christine Chichester , Egon Willighagen , Denise Slenter , Martina Summer-Kutmon , and Kristina HanspersActivity
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Cited In
- WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research (2018). Cites this version
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Organisms
Saccharomyces cerevisiaeCommunities
Annotations
Pathway Ontology
glucose conversion pathway glycogen biosynthetic pathway glucose utilization pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| UTP | Metabolite | chebi:46398 | |
| UDP-D-glucose | Metabolite | chebi:46229 | |
| H2O | Metabolite | chebi:15377 | |
| NADP | Metabolite | chebi:44409 | |
| beta-D-Glucose | Metabolite | chebi:15903 | |
| delta-Glucono-delta-lactone | Metabolite | chebi:16217 | |
| glucose-1-phosphate | Metabolite | chebi:16077 | |
| Glycogen | Metabolite | chebi:28087 | |
| pyrophosphate | Metabolite | cas:2466-09-3 | |
| (1,4-alpha-D-glucosyl)n - R | Metabolite | chebi:15444 | R = a glycogenin |
| fructose | Metabolite | cas:7776-48-9 | |
| glucose-6-phosphate | Metabolite | chebi:75150 | |
| UDP | Metabolite | chebi:17659 | |
| NADPH | Metabolite | cas:53-57-6 | |
| phosphate | Metabolite | cas:14265-44-2 | |
| (1,4-alpha-D-Glucosyl)n+1 - R | Metabolite | chebi:28102 | R = a glycogenin |
| YHL012W | GeneProduct | sgd:S000001004 | |
| PGM1 | GeneProduct | sgd:S000001610 | |
| GSY2 | GeneProduct | ensembl:YLR258W | |
| UGP1 | GeneProduct | sgd:S000001518 | |
| GSY1 | GeneProduct | ensembl:YFR015C | |
| PGM2 | GeneProduct | sgd:S000004711 | |
| GLC3 | GeneProduct | ensembl:YEL011W |
References
- Coordinate regulation of glycogen metabolism in the yeast Saccharomyces cerevisiae. Induction of glycogen branching enzyme. Thon VJ, Vigneron-Lesens C, Marianne-Pepin T, Montreuil J, Decq A, Rachez C, et al. J Biol Chem. 1992 Jul 25;267(21):15224–8. PubMed Europe PMC Scholia
- Two glycogen synthase isoforms in Saccharomyces cerevisiae are coded by distinct genes that are differentially controlled. Farkas I, Hardy TA, Goebl MG, Roach PJ. J Biol Chem. 1991 Aug 25;266(24):15602–7. PubMed Europe PMC Scholia
- Initiation of glycogen synthesis in yeast. Requirement of multiple tyrosine residues for function of the self-glucosylating Glg proteins in vivo. Mu J, Cheng C, Roach PJ. J Biol Chem. 1996 Oct 25;271(43):26554–60. PubMed Europe PMC Scholia
- Reserve carbohydrates metabolism in the yeast Saccharomyces cerevisiae. François J, Parrou JL. FEMS Microbiol Rev. 2001 Jan;25(1):125–45. PubMed Europe PMC Scholia