Pathogenic Escherichia coli infection (WP2272)

Homo sapiens

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Sources: [http://www.genome.jp/kegg/pathway/hsa/hsa05130.html KEGG] Escherichia coli (commonly abbreviated E. coli) is a gram-negative, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms (endotherms). Most E. coli strains are harmless, but some serotypes are pathogenic and can cause serious food poisoning in humans, and are occasionally responsible for product recalls. E. coli are also responsible for a majority of cases of urinary tract infections. The harmless strains are part of the normal flora of the gut, and can benefit their hosts by producing vitamin K2, and by preventing the establishment of pathogenic bacteria within the intestine. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2272 CPTAC Assay Portal]

Authors

Nathan Salomonis , Alex Pico , Denise Slenter , Andika Tan , Kristina Hanspers , Marvin Martens , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Diseases

Annotations

Cell Type Ontology

epithelial cell of small intestine epithelial cell of large intestine

Pathway Ontology

pathogenic Escherichia coli infection pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Phosphatidylethanolamine Metabolite kegg.compound:C00350
TUBB6 GeneProduct ncbigene:84617 Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
EspF GeneProduct uniprot:O85622
EspG GeneProduct uniprot:O85646
EspG2 GeneProduct uniprot:Q9EZE8
KRT18 GeneProduct ncbigene:3875 Original kegg element: gene;25;hsa:3875
ARHGEF2 GeneProduct ncbigene:9181 Original kegg element: gene;42;hsa:9181
ARPC5 GeneProduct ncbigene:10092 Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
TUBB8 GeneProduct ncbigene:347688 Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
OCLN GeneProduct ncbigene:4950 Original kegg element: gene;30;hsa:100506658 hsa:4950
TUBA8 GeneProduct ncbigene:51807 Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
EZR GeneProduct ncbigene:7430 Original kegg element: gene;31;hsa:7430
ABL1 GeneProduct ncbigene:25 Original kegg element: gene;35;hsa:25 hsa:2534
ITGB1 GeneProduct ncbigene:3688 Original kegg element: gene;40;hsa:3688
TUBB3 GeneProduct ncbigene:10381 Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
WASL GeneProduct ncbigene:8976 Original kegg element: gene;37;hsa:7454 hsa:8976
TUBB2B GeneProduct ncbigene:347733 Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
FYN GeneProduct ncbigene:2534 Original kegg element: gene;35;hsa:25 hsa:2534
CDC42 GeneProduct ncbigene:998 Original kegg element: gene;32;hsa:998
Eae GeneProduct uniprot:P43261
TUBB2C GeneProduct ncbigene:10383 Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBA4A GeneProduct ncbigene:7277 Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
StxA GeneProduct uniprot:A8B1H9
TUBA3C GeneProduct ncbigene:7278 Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
StxB GeneProduct uniprot:A7UQX3
TUBB4 GeneProduct ncbigene:10382 Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBA1C GeneProduct ncbigene:84790 Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
EspFU GeneProduct uniprot:P0DJ88
EspH GeneProduct uniprot:O85629
ACTG1 GeneProduct ncbigene:71 Original kegg element: gene;55;hsa:60 hsa:71
TLR5 GeneProduct ncbigene:7100 Original kegg element: gene;10;hsa:7100
TUBA3E GeneProduct ncbigene:112714 Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
PRKCA GeneProduct ncbigene:5578 Original kegg element: gene;36;hsa:5578
TUBA1A GeneProduct ncbigene:7846 Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
YWHAZ GeneProduct ncbigene:7534 Original kegg element: gene;23;hsa:7534
ACTB GeneProduct ncbigene:60 Original kegg element: gene;55;hsa:60 hsa:71
CLDN1 GeneProduct ncbigene:9076 Original kegg element: gene;39;hsa:9076
LY96 GeneProduct ncbigene:23643 Original kegg element: gene;3;hsa:23643
CTTN GeneProduct ncbigene:2017 Original kegg element: gene;27;hsa:2017 hsa:3059
actin-related protein 2/3 complex subunit 1B-like GeneProduct ncbigene:653888 Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
NCL GeneProduct ncbigene:4691 Original kegg element: gene;45;hsa:4691
WAS GeneProduct ncbigene:7454 Original kegg element: gene;37;hsa:7454 hsa:8976
TUBA3D GeneProduct ncbigene:113457 Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
HCLS1 GeneProduct ncbigene:3059 Original kegg element: gene;27;hsa:2017 hsa:3059
ROCK1 GeneProduct ncbigene:6093 Original kegg element: gene;28;hsa:6093 hsa:9475
Bfp GeneProduct uniprot:Q0H044
Map GeneProduct uniprot:Q9R8E4
TUBA1B GeneProduct ncbigene:10376 Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
ARPC1A GeneProduct ncbigene:10552 Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
ARPC4 GeneProduct ncbigene:10093 Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
CTNNB1 GeneProduct ncbigene:1499 Original kegg element: gene;26;hsa:1499
ARPC3 GeneProduct ncbigene:10094 Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
RHOA GeneProduct ncbigene:387 Original kegg element: gene;44;hsa:387
TUBAL3 GeneProduct ncbigene:79861 Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
ARPC5L GeneProduct ncbigene:81873 Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
ROCK2 GeneProduct ncbigene:9475 Original kegg element: gene;28;hsa:6093 hsa:9475
TUBB4Q GeneProduct ncbigene:56604 Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
occludin-like GeneProduct ncbigene:100506658 Original kegg element: gene;30;hsa:100506658 hsa:4950
TUBB1 GeneProduct ncbigene:81027 Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
ARPC2 GeneProduct ncbigene:10109 Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
CD14 GeneProduct ncbigene:929 Original kegg element: gene;2;hsa:929
TUBB GeneProduct ncbigene:203068 Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
CDH1 GeneProduct ncbigene:999 Original kegg element: gene;17;hsa:999
Tir GeneProduct uniprot:P0DJ92
NCK1 GeneProduct ncbigene:4690 Original kegg element: gene;41;hsa:4690 hsa:8440
NCK2 GeneProduct ncbigene:8440 Original kegg element: gene;41;hsa:4690 hsa:8440
YWHAQ GeneProduct ncbigene:10971 Original kegg element: gene;18;hsa:10971
TUBB2A GeneProduct ncbigene:7280 Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TLR4 GeneProduct ncbigene:7099 Original kegg element: gene;9;hsa:7099
ARPC1B GeneProduct ncbigene:10095 Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
NleH GeneProduct uniprot:D3QNI6
NleA GeneProduct uniprot:Q71HP5

References

  1. Pathogenic Escherichia coli. Kaper JB, Nataro JP, Mobley HL. Nat Rev Microbiol. 2004 Feb;2(2):123–40. PubMed Europe PMC Scholia