Crystal toxin triggered necrosis pathway (WP3648)
Caenorhabditis elegans
This pathway is modeled on a description provided in Zhang et al. under the title "A deficiency in the necrosis pathway confers tolerance to Cry6Aa". Cry6Aa binds to the calcium channel ITR-1 and increases intracellular Ca2+ levels. Ca2+ binds to and activates Calpain TRA-3 which promotes cysteine protease activity. Cysteine Protease activates VHA-12 that uses ATP to increase pH of the cytosol. The increase in H+ concentration signals to the ASP-1/ASP-3/ASP-4 complex which leads to activation of killer cathepsin protease and leads to cell necrosis.
Authors
AAR&Co , Elisa Cirillo , Kristina Hanspers , and Eric WeitzActivity
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Organisms
Caenorhabditis elegansCommunities
Annotations
Disease Ontology
gas gangrenePathway Ontology
signaling pathway necrosis pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Ca2+ | Metabolite | pubchem.compound:271 | |
| H+ | Metabolite | pubchem.compound:1038 | |
| ATP | Metabolite | hmdb:HMDB0001532 | |
| ITR-1 Channel | GeneProduct | ensembl:WBGene00002173 | |
| VHA-12 | GeneProduct | ensembl:WBGene00006921 | |
| Killer Cathepsin Protease | GeneProduct | ensembl:WBGene00000783 | |
| ASP-1 | GeneProduct | ensembl:WBGene00000214 | |
| Cysteine Protease | GeneProduct | ensembl:WBGene00000543 | |
| Cry6Aa | GeneProduct | uniprot:Q45757 | |
| ASP-3 | GeneProduct | ensembl:WBGene00000216 | |
| ASP-4 | GeneProduct | ensembl:WBGene00000217 | |
| Calpain TRA-3 | GeneProduct | ensembl:WBGene00006606 |
References
- Bacillus thuringiensis Crystal Protein Cry6Aa Triggers Caenorhabditis elegans Necrosis Pathway Mediated by Aspartic Protease (ASP-1). Zhang F, Peng D, Cheng C, Zhou W, Ju S, Wan D, et al. PLoS Pathog. 2016 Jan 21;12(1):e1005389. PubMed Europe PMC Scholia