Female steroid hormones in cardiomyocyte energy metabolism (WP5318)
Homo sapiens
This pathway depicts the effect of estrogen and progesterone on energy metabolism in cardiomyocytes.
Authors
Mehaa Prabakar , Natalie Varahram , Liana Tyrrell , Egon Willighagen , Andra Waagmeester , Alex Pico , and Eric WeitzActivity
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Cited In
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Organisms
Homo sapiensCommunities
Annotations
Cell Type Ontology
cardiac muscle cellPathway Ontology
classic metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Cyclic GMP | Metabolite | chebi:16356 | |
| Tamoxifen | Metabolite | chebi:41774 | |
| 17OH-progesterone | Metabolite | reactome:R-HSA-194002 | |
| Ca2+ | Metabolite | pid.pathway:9606 | |
| cAMP | Metabolite | chebi:17489 | |
| Estrogen | Metabolite | chebi:50114 | |
| Superoxide radical | Metabolite | chebi:18421 | |
| 11-deoxycortisol | Metabolite | reactome:R-HSA-194002 | |
| MTP | GeneProduct | ensembl:ENSG00000138823 | |
| cTNL | GeneProduct | kegg.genes:hsa:1514 | |
| FoxO1 | GeneProduct | uniprot:UP000005640 | |
| GLUT4 | GeneProduct | ensembl:ENSG00000181856 | |
| ppara | GeneProduct | ensembl:ENSG00000186951 | |
| HADHB | GeneProduct | ensembl:ENSG00000138029 | |
| GATA4 | GeneProduct | ensembl:ENSG00000181856 | |
| MYH6 | GeneProduct | uniprot:UP000005640 | |
| Inhibition of TNF-a | GeneProduct | uniprot:UP000005640 | |
| ROS | GeneProduct | uniprot:UP000002494 | |
| acadm | GeneProduct | ensembl:ENSG00000117054 | |
| Elk-1 | GeneProduct | uniprot:UP000005640 | |
| MEF2 | GeneProduct | uniprot:UP0000005640 | |
| SOD2 | GeneProduct | ensembl:ENSG00000291237 | |
| GLUT1 | GeneProduct | ensembl:ENSG00000181856 | |
| PKB | Protein | ensembl:ENSG00000105221 | |
| Apob-lipoprotein | Protein | ensembl:ENSG00000084674 | |
| LKB1 | Protein | ensembl:ENSG00000118046 | |
| ERa | Protein | uniprot:P03372 | |
| Troponin | Protein | uniprot:UP000005640 | |
| 21-hydrolase | Protein | reactome:R-HSA-194002 | |
| PGC-1α | Protein | uniprot:Q86YN6 | |
| RyR2 | Protein | ensembl:ENST000006099119.1 | |
| eNOS | Protein | ensembl:ENSG00000164867 | |
| PPARα | Protein | uniprot:Q07869 | |
| MCAD | Protein | uniprot:P11310 | |
| ATP citrate synthase | Protein | uniprot:P53396 | |
| NOS3 | Protein | ensembl:ENSG00000164867 | |
| ERRa | Protein | uniprot:P11474 | |
| ERb | Protein | uniprot:P11474 | |
| Progesterone | Protein | uniprot:P11474 | |
| PGR | Protein | uniprot:P11474 |
References
- PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage. Hsieh YC, Yang S, Choudhry MA, Yu HP, Rue LW 3rd, Bland KI, et al. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2665-72. PubMed Europe PMC Scholia
- Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha. Barros RPA, Machado UF, Warner M, Gustafsson JA. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1605–8. PubMed Europe PMC Scholia
- Functions of AMP-activated protein kinase in adipose tissue. Daval M, Foufelle F, Ferré P. J Physiol. 2006 Jul 1;574(Pt 1):55–62. PubMed Europe PMC Scholia
- Transcriptional control of energy homeostasis by the estrogen-related receptors. Giguère V. Endocr Rev. 2008 Oct;29(6):677–96. PubMed Europe PMC Scholia
- Estrogen receptor alpha interacts with mitochondrial protein HADHB and affects beta-oxidation activity. Zhou Z, Zhou J, Du Y. Mol Cell Proteomics. 2012 Jul;11(7):M111.011056. PubMed Europe PMC Scholia
- Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function. Wang T, McDonald C, Petrenko NB, Leblanc M, Wang T, Giguere V, et al. Mol Cell Biol. 2015 Apr;35(7):1281–98. PubMed Europe PMC Scholia
- Glucose Transporters in Cardiac Metabolism and Hypertrophy. Shao D, Tian R. Compr Physiol. 2015 Dec 15;6(1):331–51. PubMed Europe PMC Scholia
- Cardiomyocyte Regulation of Systemic Lipid Metabolism by the Apolipoprotein B-Containing Lipoproteins in Drosophila. Lee S, Bao H, Ishikawa Z, Wang W, Lim HY. PLoS Genet. 2017 Jan 17;13(1):e1006555. PubMed Europe PMC Scholia
- The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy. Yuan J, Dong X, Yap J, Hu J. J Hematol Oncol. 2020 Aug 17;13(1):113. PubMed Europe PMC Scholia
- PPAR control of metabolism and cardiovascular functions. Montaigne D, Butruille L, Staels B. Nat Rev Cardiol. 2021 Dec;18(12):809–23. PubMed Europe PMC Scholia