Adipogenesis (WP236)
Homo sapiens
The different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from preadipocytes to adipocytes (fat cells). Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
Authors
Mary-Elizabeth Patti , Kristina Hanspers , Nathan Salomonis , Martijn Van Iersel , Alex Pico , Andika Tan , Egon Willighagen , and Eric WeitzActivity
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Cited In
- Comprehensive Statistical and Bioinformatics Analysis in the Deciphering of Putative Mechanisms by Which Lipid-Associated GWAS Loci Contribute to Coronary Artery Disease (2022).
- microRNA-27a-3p but Not -5p Is a Crucial Mediator of Human Adipogenesis (2021).
- Disrupting biological sensors of force promotes tissue regeneration in large organisms (2021).
- Assessing the Contribution of Relative Macrophage Frequencies to Subcutaneous Adipose Tissue (2021).
- The DNA methylome of inflammatory bowel disease (IBD) reflects intrinsic and extrinsic factors in intestinal mucosal cells (2020).
- Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype (2016).
- Circadian transcriptome analysis in human fibroblasts from Hunter syndrome and impact of iduronate-2-sulfatase treatment (2013).
- A patient-based iPSC-derived hepatocyte model of alcohol-associated cirrhosis reveals bioenergetic insights into disease pathogenesis (2024).
- MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity.
- In silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions (2023).
- Bioinformatics analysis of the pathogenic link between Epstein-Barr virus infection, systemic lupus erythematosus and diffuse large B cell lymphoma (2023).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
signaling pathway pertinent to developmentCell Type Ontology
fat cell preadipocyte| Label | Type | Compact URI | Comment |
|---|---|---|---|
| STAT5A | GeneProduct | ncbigene:6776 | |
| LPIN2 | GeneProduct | ncbigene:9663 | |
| DDIT3 | GeneProduct | ncbigene:1649 | |
| WNT5B | GeneProduct | ncbigene:81029 | |
| RORA | GeneProduct | ncbigene:6095 |
References
- Molecular regulation of adipogenesis. Rosen ED, Spiegelman BM. Annu Rev Cell Dev Biol. 2000;16:145–71. PubMed Europe PMC Scholia