Statin inhibition of cholesterol production (WP430)

Homo sapiens

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Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism. Sources: [https://www.pharmgkb.org/pathway/PA2031 PharmGKB] and [http://en.wikipedia.org/wiki/Statin Wikipedia] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP430 CPTAC Assay Portal].

Authors

Nathan Salomonis , Alex Pico , Kristina Hanspers , Thomas Kelder , Bruce Conklin , Samuel Sklar , Egon Willighagen , Martina Summer-Kutmon , Chris Evelo , Anwesha Bohler , Denise Slenter , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Diseases Serious Request 2024 - MetaKids

Annotations

Disease Ontology

cardiovascular system disease

Cell Type Ontology

hepatocyte enterocyte

Pathway Ontology

statin drug pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Cholesterol Metabolite cas:57-88-5
Squalene Metabolite hmdb:HMDB0000256
Acyl-CoA Metabolite chebi:17984
Phospholipid Metabolite kegg.compound:C00865
DAG Metabolite kegg.compound:C00165
VLDL Metabolite chebi:39027
Cholesterol ester Metabolite kegg.compound:C02530
Statin Metabolite chebi:35664
HMG-CoA Metabolite hmdb:HMDB0001375
IDL Metabolite chebi:132933
Lipoproteins Metabolite chebi:6495
Mevalonate Metabolite chebi:25350
HDL Metabolite chebi:47775
Fatty acid Metabolite kegg.compound:C00162
Cholic Acid Metabolite cas:81-25-4
LDL Metabolite chebi:47774
Triglyceride Metabolite kegg.compound:C00422
ABCA1 GeneProduct ncbigene:19
ABCG8 GeneProduct ncbigene:64241
APOA1 GeneProduct ncbigene:335
APOA4 GeneProduct ncbigene:337
APOC2 GeneProduct ncbigene:344
MIR33A GeneProduct ensembl:ENSG00000207932
APOC3 GeneProduct ncbigene:345
APOC1 GeneProduct ncbigene:341
APOA5 GeneProduct ncbigene:116519
CYP7A1 GeneProduct ncbigene:1581
SCARB1 GeneProduct ncbigene:949
PLTP GeneProduct ncbigene:5360
ABCG5 GeneProduct ncbigene:64240
APOA2 GeneProduct ncbigene:336
LCAT GeneProduct ncbigene:3931
LDLR GeneProduct ncbigene:3949
APOB GeneProduct ncbigene:338
DGAT1 GeneProduct ncbigene:8694
LPL GeneProduct ncbigene:4023
MIR33B GeneProduct ensembl:ENSG00000207839
SQLE GeneProduct ncbigene:6713
LIPC GeneProduct ncbigene:3990
SOAT1 GeneProduct ncbigene:6646
APOE GeneProduct ncbigene:348
LRP1 GeneProduct ncbigene:4035
FDFT1 GeneProduct ncbigene:2222
CETP GeneProduct ncbigene:1071
HMGCR GeneProduct ncbigene:3156
Acyl-CoA synthetase Protein ncbigene:84532
MTTP Protein ncbigene:4547
PDIA2 Protein ncbigene:64714

References

  1. Microsomal triglyceride transfer protein. Wetterau JR, Lin MC, Jamil H. Biochim Biophys Acta. 1997 Apr 1;1345(2):136–50. PubMed Europe PMC Scholia
  2. Direct effects of statins on cells primarily involved in atherosclerosis. Chen H, Ikeda U, Shimpo M, Shimada K. Hypertens Res. 2000 Mar;23(2):187–92. PubMed Europe PMC Scholia