Canonical and non-canonical TGF-B signaling (WP3874)

Homo sapiens

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This pathway is modeled after Figure 9 in the article “Gremlin utilizes canonical and non-canonical TGFB signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells”. Gremlin is enables the TGF-B signaling pathways to oversee LOX and LOXL proteins and also demonstrates that the non-canonical JNK1/2 complex, canonical SMAD, and P38 signaling pathways are involved in this pathway. TGF-B signaling is possible through Gremlin’s ability to bock the BMP signaling pathway which inhibits TGF-B receptors. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Authors

AAR&Co , Friederike Ehrhart , Kristina Hanspers , Eric Weitz , and Egon Willighagen

Activity

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Cited In

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Organisms

Homo sapiens

Communities

ONTOX

Annotations

Cell Type Ontology

trabecular meshwork cell

Pathway Ontology

Bone morphogenetic proteins signaling pathway

Disease Ontology

primary angle-closure glaucoma

Participants
Query Drugst.One

Label Type Compact URI Comment
SMAD4 GeneProduct ensembl:ENSG00000141646
BMPR2 GeneProduct ensembl:ENSG00000204217
MAPK14 GeneProduct ensembl:ENSG00000112062 P38
SMAD3 GeneProduct ensembl:ENSG00000166949
LOXL4 GeneProduct ensembl:ENSG00000138131
BMP1 GeneProduct ensembl:ENSG00000168487 BMP
LOXL2 GeneProduct ensembl:ENSG00000134013
LOXL1 GeneProduct ensembl:ENSG00000129038
GREM1 GeneProduct ensembl:ENSG00000166923 Grem
LOX GeneProduct ensembl:ENSG00000113083
JNK2 GeneProduct ensembl:ENSG00000050748
JNK1 GeneProduct ensembl:ENSG00000107643
TGFBR2 GeneProduct ensembl:ENSG00000163513
SMAD2 GeneProduct ensembl:ENSG00000175387
TGFBR1 GeneProduct ensembl:ENSG00000106799
BMPR1 GeneProduct ensembl:ENSG00000107779
TGFB1 GeneProduct ensembl:ENSG00000105329 TGF-Beta

References

  1. Gremlin utilizes canonical and non-canonical TGFβ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells. Sethi A, Wordinger RJ, Clark AF. Exp Eye Res. 2013 Aug;113:117–27. PubMed Europe PMC Scholia