Adverse outcome pathway for mitochondrial complex 1 (C1) inhibition (WP4914)

Homo sapiens

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Adverse Outcome Pathway (AOP) network for mitochondrial Complex 1 (C1) inhibition leading to adverse outcomes in kidney, brain and liver. Adverse Outcome Pathways (AOPs), in general, are defined as a sequence of key events that begins with a molecular initiating event (MIE) and leads to an Adverse Outcome. At that level, AOPs are described in the [https://aopwiki.org/ AOPWiki]. This AOP network is based on 3 AOPs: [https://aopwiki.org/aops/3 AOPwiki:3], [https://aopwiki.org/aops/273 AOPwiki:273] and [https://aopwiki.org/aops/276 AOPwiki:276].

Authors

Anna Baya Meuleman , Egon Willighagen , Marvin Martens , Chris Evelo , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

immune response pathway altered energy metabolic pathway

Disease Ontology

Fanconi-like syndrome Parkinson's disease

Participants

Label Type Compact URI Comment
Deguelin Metabolite chebi:4357
Rotenone Metabolite chebi:28201

References