Fas ligand pathway and stress induction of heat shock proteins (WP314)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP314 CPTAC Assay Portal]

Authors

Kristina Hanspers , Thomas Kelder , JT. Saito , Jildau Bouwman , Alex Pico , Christine Chichester , Zahra Roudbari , Marianthi Kalafati , Lauren J. Dupuis , Eric Weitz , and Egon Willighagen

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

stress response pathway FasL mediated signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Phosphate Metabolite hmdb:HMDB0001429
Glutathione Metabolite hmdb:HMDB0000125
Ceramide Metabolite cas:104404-17-3
SPTAN1 GeneProduct ncbigene:6709 Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
IL1A GeneProduct ncbigene:3552
FAF1 GeneProduct ncbigene:11124
CASP7 GeneProduct ncbigene:840
HSPB1 GeneProduct ncbigene:3315
RIPK2 GeneProduct ncbigene:8767 receptor (TNFRSF)-interacting serine-threonine kinase 2
DFFB GeneProduct ncbigene:1677
PAK1 GeneProduct ncbigene:5058
APAF1 GeneProduct ncbigene:317
DAXX GeneProduct ncbigene:1616
MAPKAPK2 GeneProduct ncbigene:9261
CASP8 GeneProduct ncbigene:841
PARP1 GeneProduct ncbigene:142
DFFA GeneProduct ncbigene:1676
ARHGDIB GeneProduct ncbigene:397 Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
CYCS GeneProduct ncbigene:54205
FASLG GeneProduct ncbigene:356
FADD GeneProduct ncbigene:8772
CASP10 GeneProduct ncbigene:843
RB1 GeneProduct ncbigene:5925
ACTA1 GeneProduct ncbigene:58
MAPK8 GeneProduct ncbigene:5599
JUN GeneProduct ncbigene:3725
MAPKAPK3 GeneProduct ncbigene:7867
MAP2K4 GeneProduct ncbigene:6416
CASP6 GeneProduct ncbigene:839
PAK2 GeneProduct ncbigene:5062
MAP3K7 GeneProduct ncbigene:6885
LMNB1 GeneProduct ncbigene:4001
LMNB2 GeneProduct ncbigene:84823
CASP9 GeneProduct ncbigene:842
CFLAR GeneProduct ncbigene:8837
BCL2 GeneProduct ncbigene:596
MAP3K1 GeneProduct ncbigene:4214
CASP3 GeneProduct ncbigene:836
TNF GeneProduct ncbigene:7124
PRKDC GeneProduct ncbigene:5591
LMNA GeneProduct ncbigene:4000
FAP1 GeneProduct ncbigene:4799
FAS GeneProduct ncbigene:355
ACTB GeneProduct ncbigene:60
ACTG1 GeneProduct ncbigene:71

References

  1. Heat shock proteins--modulators of apoptosis in tumour cells. Creagh EM, Sheehan D, Cotter TG. Leukemia. 2000 Jul;14(7):1161–73. PubMed Europe PMC Scholia
  2. Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. Ji Q, Hao X, Meng Y, Zhang M, Desano J, Fan D, et al. BMC Cancer. 2008 Sep 21;8:266. PubMed Europe PMC Scholia