Renin-angiotensin-aldosterone system (RAAS) (WP4756)
Homo sapiens
The pathway leading angiotensinogen to aldosterone
Authors
Ozan Ozisik , Marvin Martens , Egon Willighagen , and Eric WeitzActivity
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Cited In
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
angiotensin signaling pathway aldosterone biosynthetic pathway renin-angiotensin cascade pathway ACE inhibitor drug pathwayDisease Ontology
hypertension| Label | Type | Compact URI | Comment |
|---|---|---|---|
| 18-Hydroxycorticosterone | Metabolite | chebi:16485 | |
| IP3 | Metabolite | chebi:16595 | |
| Corticosterone | Metabolite | chebi:16827 | |
| 11-Deoxycorticosterone | Metabolite | chebi:16973 | |
| Progesterone | Metabolite | chebi:17026 | |
| Cholesterol | Metabolite | chebi:16113 | |
| Angiotensin II | Metabolite | hmdb:HMDB0001035 | |
| Angiotensin I | Metabolite | pubchem.compound:3081372 | |
| ACE inhibitor | Metabolite | chebi:35457 | |
| Pregnenolone | Metabolite | chebi:16581 | |
| Ca2+ | Metabolite | chebi:29108 | |
| Aldosterone | Metabolite | hmdb:HMDB0000037 | |
| CYP11A1 | GeneProduct | hgnc.symbol:CYP11A1 | |
| HSD3B2 | GeneProduct | hgnc.symbol:HSD3B2 | |
| CALML5 | GeneProduct | hgnc.symbol:CALML5 | |
| CAMK1D | GeneProduct | hgnc.symbol:CAMK1D | |
| CYP21A2 | GeneProduct | hgnc.symbol:CYP21A2 | |
| CYP11B2 | GeneProduct | hgnc.symbol:CYP11B2 | |
| CALM1 | GeneProduct | hgnc.symbol:CALM1 | |
| CALML6 | GeneProduct | hgnc.symbol:CALML6 | |
| ITPR1 | GeneProduct | hgnc.symbol:ITPR1 | |
| CALML3 | GeneProduct | hgnc.symbol:CALML3 | |
| CTSG | GeneProduct | ncbigene:1511 | |
| CALML4 | GeneProduct | hgnc.symbol:CALML4 | |
| ITPR2 | GeneProduct | hgnc.symbol:ITPR2 | |
| HSD3B1 | GeneProduct | hgnc.symbol:HSD3B1 | |
| ITPR3 | GeneProduct | hgnc.symbol:ITPR3 | |
| CALM2 | GeneProduct | hgnc.symbol:CALM2 | |
| PLCB2 | GeneProduct | hgnc.symbol:PLCB2 | |
| CMA1 | GeneProduct | ncbigene:1215 | |
| REN | GeneProduct | ncbigene:5972 | |
| ATF6B | GeneProduct | hgnc.symbol:ATF6B | |
| AGT | GeneProduct | ncbigene:183 | |
| ACE | GeneProduct | ncbigene:1636 | |
| CALM3 | GeneProduct | hgnc.symbol:CALM3 | |
| GNAQ | GeneProduct | hgnc.symbol:GNAQ | |
| AGTR2 | GeneProduct | ncbigene:186 | |
| AGTR1 | GeneProduct | ncbigene:185 | |
| CAMK1G | GeneProduct | hgnc.symbol:CAMK1G | |
| CAMK4 | GeneProduct | hgnc.symbol:CAMK4 | |
| CAMK2A | GeneProduct | hgnc.symbol:CAMK2A | |
| CAMK2B | GeneProduct | hgnc.symbol:CAMK2B | |
| CAMK2D | GeneProduct | hgnc.symbol:CAMK2D | |
| CAMK2G | GeneProduct | hgnc.symbol:CAMK2G | |
| CAMK1 | GeneProduct | hgnc.symbol:CAMK1 | |
| ATF2 | GeneProduct | hgnc.symbol:ATF2 | |
| ATF1 | GeneProduct | hgnc.symbol:ATF1 | |
| CREB5 | GeneProduct | hgnc.symbol:CREB5 | |
| CREB3L4 | GeneProduct | hgnc.symbol:CREB3L4 | |
| CREB3L3 | GeneProduct | hgnc.symbol:CREB3L3 | |
| CREB3L2 | GeneProduct | hgnc.symbol:CREB3L2 | |
| CREB3L1 | GeneProduct | hgnc.symbol:CREB3L1 | |
| CREB3 | GeneProduct | hgnc.symbol:CREB3 | |
| CREB1 | GeneProduct | hgnc.symbol:CREB1 | |
| ATF4 | GeneProduct | hgnc.symbol:ATF4 | |
| STAR | Protein | hgnc.symbol:STAR |
References
- The regulation of aldosterone synthase expression. Bassett MH, White PC, Rainey WE. Mol Cell Endocrinol. 2004 Mar 31;217(1–2):67–74. PubMed Europe PMC Scholia
- Pharmacogenetics of antihypertensive drug responses. Schwartz GL, Turner ST. Am J Pharmacogenomics. 2004;4(3):151–60. PubMed Europe PMC Scholia
- Aldosterone biosynthesis, regulation, and classical mechanism of action. Williams GH. Heart Fail Rev. 2005 Jan;10(1):7–13. PubMed Europe PMC Scholia
- Effects of renin-angiotensin system inhibition on end-organ protection: can we do better? Weir MR. Clin Ther. 2007 Sep;29(9):1803–24. PubMed Europe PMC Scholia