Isoleucine biosynthesis (WP250)

Saccharomyces cerevisiae

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The pathway of L-isoleucine biosynthesis from L-threonine is a five-step pathway that shares several steps with the pathway of L-valine biosynthesis (https://www.wikipathways.org/pathways/WP2.html). These entwined pathways are part of the superpathway of branched chain amino acid biosynthesis, that generates not only L-isoleucine and L-valine, but also L-leucine. Source: BioCyc https://biocyc.org/graphics2021/BioCyc.svg

Authors

Meredith Braymer , Daniela Digles , Egon Willighagen , Eric Weitz , and Kristina Hanspers

Activity

last edited

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Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

isoleucine biosynthetic pathway classic metabolic pathway

Participants

Label Type Compact URI Comment
2-Aceto-2-hydroxybutyrate Metabolite pubchem.compound:21
CO2 Metabolite chebi:16526
L-glutamate Metabolite cas:56-86-0
NADPH Metabolite cas:53-57-6
2,3-Dihydroxy-3-methylvalerate Metabolite chebi:882
2-keto-3-methylvalerate Metabolite chebi:28654
L-threonine Metabolite cas:72-19-5
pyruvate Metabolite chebi:15361
NH3 Metabolite hmdb:HMDB00051
L-isoleucine Metabolite chebi:58045
2-oxoglutarate Metabolite chebi:16810
H+ Metabolite hmdb:HMDB59597
H2O Metabolite hmdb:HMDB02111
NADP Metabolite chebi:44409
2-oxobutanoate Metabolite chebi:16763
ILV3 GeneProduct sgd:S000003777
BAT1 GeneProduct sgd:S000001251
BAT2 GeneProduct sgd:S000003909
ILV6 GeneProduct sgd:S000000515
ILV1 GeneProduct sgd:S000000888
ILV5 GeneProduct sgd:S000004347
ILV2 GeneProduct sgd:S000004714

References

  1. Regulation of isoleucine-valine biosynthesis in Saccharomyces cerevisiae. Holmberg S, Petersen JG. Curr Genet. 1988 Mar;13(3):207–17. PubMed Europe PMC Scholia
  2. URL: https://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=ILEUSYN-PWY-1