SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction (WP5183)

Homo sapiens

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Long COVID-19 (Coronavirus disease) ranges from lingering symptoms 6-12 months after contracting COVID-19 to severe implications caused by the virus. To understand the (molecular) mechanisms underlying Long COVID-19 and the potential role of chronic oxidative stress, this pathway concisely visualises mitochondrial hijacking by SARS-COV-2 leading to pro-senescent mitochondrial dysfunction and inflammation.

Authors

Kingson ''junsheng Thang'' Luc , Martina Summer-Kutmon , Celine Malyar , Jing Jing Cai , Egon Willighagen , Isabel Wassink , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

COVID-19

Annotations

Pathway Ontology

signaling pathway oxidative stress response pathway

Disease Ontology

long COVID COVID-19

Participants
Query Drugst.One

Label Type Compact URI Comment
MtROS Metabolite chebi:26523
PGC1 Metabolite chebi:15546
Angiotensin I Metabolite chebi:2718
Angiotensin II Metabolite chebi:2719
Angiotensin-(1-9) Metabolite chebi:80128
Angiotensin (1-7) Metabolite chebi:55438
NDUFAF2 GeneProduct ensembl:ENSG00000164182
NLRP3 GeneProduct ensembl:ENSG00000162711
TERF2IP GeneProduct ensembl:ENSG00000166848
SIRT6 GeneProduct ensembl:ENSG00000077463
NDUFAF1 GeneProduct ensembl:ENSG00000137806
NF-kB GeneProduct ensembl:ENSG00000109320
TERF2 GeneProduct ensembl:ENSG00000132604
ACAD9 GeneProduct ensembl:ENSG00000177646
ECSIT GeneProduct ensembl:ENSG00000130159
BCS1KL GeneProduct ensembl:ENSG00000074582
NLRX1 GeneProduct ensembl:ENSG00000160703
MAVS GeneProduct ensembl:ENSG00000088888
TOMM70 GeneProduct ensembl:ENSG00000154174
TRAF3 GeneProduct ensembl:ENSG00000131323
TRAF6 GeneProduct ensembl:ENSG00000175104
NFIP2 GeneProduct uniprot:Q9NV92
RIG-I GeneProduct uniprot:095786
PHB1 GeneProduct uniprot:P35232
NOX1 GeneProduct uniprot:Q9Y5S8
TMEM173 GeneProduct uniprot:Q86WV6
ACE2 GeneProduct uniprot:Q9BYF1
AGT GeneProduct uniprot:P01019
ACE GeneProduct uniprot:P12821
Renin GeneProduct uniprot:P00797
p90rsk Protein uniprot:E9PGT3
IL-18 Protein uniprot:Q14116
IL-6 Protein uniprot:P05231
nsp7 Protein uniprot:P0DTD1
IL-1β Protein chebi:138181
TNF Protein uniprot:Q5STB3
orf9c Protein uniprot:P0DTD3
orf9b Protein uniprot:P0DTD2
nsp2 Protein ncbiprotein:YP_009725298

References

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  7. The roles of signaling pathways in SARS-CoV-2 infection; lessons learned from SARS-CoV and MERS-CoV. Hemmat N, Asadzadeh Z, Ahangar NK, Alemohammad H, Najafzadeh B, Derakhshani A, et al. Arch Virol. 2021 Mar;166(3):675–96. PubMed Europe PMC Scholia
  8. SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress. Chang R, Mamun A, Dominic A, Le NT. Front Physiol. 2021 Jan 15;11:605908. PubMed Europe PMC Scholia