Small ligand GPCRs (WP161)
Rattus norvegicus
G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [https://en.wikipedia.org/wiki/G_protein–coupled_receptor Wikipedia] These small ligand receptors are part of the Rhodopsin-like family of GPCRs. Source: [https://en.wikipedia.org/wiki/Rhodopsin-like_receptors Wikipedia]
Authors
Nathan Salomonis , Manny Ramirez , Daniela Digles , Egon Willighagen , Kristina Hanspers , and Eric WeitzActivity
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Cited In
- Unraveling the blood transcriptome after real-life exposure of Wistar-rats to PM2.5, PM1 and water-soluble metals in the ambient air (2020).
- Microarray analyses reveal novel targets of exercise-induced stress resistance in the dorsal raphe nucleus (2013).
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Organisms
Rattus norvegicusCommunities
Annotations
Pathway Ontology
G protein mediated signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Melatonin | Metabolite | chebi:16796 | |
| Cannabinoid | Metabolite | chebi:67194 | |
| Prostanoids | Metabolite | chebi:26347 | |
| Cnr1 | GeneProduct | ncbigene:25248 | |
| Cnr2 | GeneProduct | ncbigene:57302 | |
| S1pr1 | GeneProduct | ncbigene:29733 | |
| Lpar1 | GeneProduct | ncbigene:116744 | |
| S1pr3 | GeneProduct | ncbigene:306792 | |
| S1pr2 | GeneProduct | ncbigene:29415 | |
| S1pr4 | GeneProduct | ncbigene:314649 | |
| Mtnr1a | GeneProduct | ncbigene:114211 | |
| Ptafr | GeneProduct | ncbigene:58949 | |
| PTGDR | GeneProduct | ncbigene:498475 | |
| Ptger1 | GeneProduct | ncbigene:25637 | |
| Ptger2 | GeneProduct | ncbigene:81752 | |
| Ptger3 | GeneProduct | ncbigene:24929 | |
| Ptger4 | GeneProduct | ncbigene:84023 | |
| Ptgfr | GeneProduct | ncbigene:25652 | |
| Ptgir | GeneProduct | ncbigene:292661 | |
| Tbxa2r | GeneProduct | ncbigene:24816 | |
| Mtnr1b | GeneProduct | ncbigene:192646 |