Gut-liver indole metabolism (WP3627)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Dietary tryptophane is metabolised by the gut microbiome to indole and IPA which reaches the human blood system. Indole is further metabolized into indoxyl sulfate which also reached the blood.

Authors

Egon Willighagen , Kristina Hanspers , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

classic metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
indoxyl Metabolite chebi:17840
IPA Metabolite chebi:43580
indole Metabolite chebi:16881
dietarytryptophan Metabolite chebi:27897
indoxyl sulfate Metabolite chebi:43355
tryptophanase GeneProduct eccode:4.1.99.1
CYP2E1 GeneProduct ensembl:ENSG00000130649

References

  1. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Wikoff WR, Anfora AT, Liu J, Schultz PG, Lesley SA, Peters EC, et al. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698–703. PubMed Europe PMC Scholia