Cytosolic DNA-sensing pathway (WP4655)

Homo sapiens

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As part of the innate immune system, specific cytosolic pattern recognition receptors recognize DNA from invading viruses and bacteria. These receptors have specificity for certain pathogens. The three receptors that recognize double-stranded cytosolic DNA are CGAS (GMP-AMP Synthase), ZBP1 (DAI) and AIM. CGAS signals via STING (TREM173) and eventually results in expression of type I interferons. ZBP1 activates NFkb and IRF transcription factors which results in expression of interferons and cytokines/chemokines. Activation of AIM leads to the formation of the inflammasome complex, which activates caspase-1 and triggers a form of apoptosis known as pyroptosis. In addition to sensors that directly detect DNA, another mechanism exists where the foreign DNA is first translated into RNA by host polymerase. The RNA is then recognized by the RNA sensor RIG-I, which leads to NFkb and IRF activation.

Authors

Kristina Hanspers and Egon Willighagen

Activity

last edited

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Organisms

Homo sapiens

Communities

CPTAC

Annotations

Disease Ontology

viral infectious disease bacterial infectious disease

Pathway Ontology

pattern recognition receptor mediated signaling pathway signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
cGAMP Metabolite chebi:71580
dsDNA Metabolite chebi:16991
dsDNA Metabolite chebi:16991
POLR2E GeneProduct ensembl:ENSG00000099817
POLR3GL GeneProduct ensembl:ENSG00000121851
POLR3F GeneProduct ensembl:ENSG00000132664
POLR3G GeneProduct ensembl:ENSG00000113356
POLR3H GeneProduct ensembl:ENSG00000100413
POLR2K GeneProduct ensembl:ENSG00000147669
POLR2H GeneProduct ensembl:ENSG00000163882
POLR3E GeneProduct ensembl:ENSG00000058600
POLR3K GeneProduct ensembl:ENSG00000161980
POLR2F GeneProduct ensembl:ENSG00000100142
POLR2L GeneProduct ensembl:ENSG00000177700
POLR3A GeneProduct ensembl:ENSG00000148606
TREX1 GeneProduct ensembl:ENSG00000213689
POLR1C GeneProduct ensembl:ENSG00000171453
POLR3C GeneProduct ensembl:ENSG00000186141
POLR3D GeneProduct ensembl:ENSG00000168495
POLR3B GeneProduct ensembl:ENSG00000013503
POLR1D GeneProduct ensembl:ENSG00000186184
ADAR GeneProduct ensembl:ENSG00000160710
ZBP1 GeneProduct ensembl:ENSG00000124256
RIPK1 GeneProduct ensembl:ENSG00000137275
RIPK3 GeneProduct ensembl:ENSG00000129465
IKBKG GeneProduct ensembl:ENSG00000269335
IKBKB GeneProduct ensembl:ENSG00000104365
CHUK GeneProduct ensembl:ENSG00000213341
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ensembl:ENSG00000173039
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ensembl:ENSG00000173039
NFKBIA GeneProduct ensembl:ENSG00000100906
NFKBIB GeneProduct ensembl:ENSG00000104825
NFKBIA GeneProduct ensembl:ENSG00000100906
NFKBIB GeneProduct ensembl:ENSG00000104825
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ensembl:ENSG00000173039
IL6 GeneProduct ensembl:ENSG00000136244
CCL4L2 GeneProduct ensembl:ENSG00000276070
CCL5 GeneProduct ensembl:ENSG00000271503
CXCL10 GeneProduct ensembl:ENSG00000169245
AIM2 GeneProduct ensembl:ENSG00000163568
CASP1 GeneProduct ensembl:ENSG00000137752
PYCARD GeneProduct ensembl:ENSG00000103490
IL1B GeneProduct ensembl:ENSG00000125538
IL18 GeneProduct ensembl:ENSG00000150782
IL33 GeneProduct ensembl:ENSG00000137033
IRF3 GeneProduct ensembl:ENSG00000126456
IRF7 GeneProduct ensembl:ENSG00000185507
IRF3 GeneProduct ensembl:ENSG00000126456
IRF7 GeneProduct ensembl:ENSG00000185507
IFNA10 GeneProduct ncbigene:3446 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA8 GeneProduct ncbigene:3445 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA16 GeneProduct ncbigene:3449 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA2 GeneProduct ncbigene:3440 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA7 GeneProduct ncbigene:3444 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA21 GeneProduct ncbigene:3452 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA17 GeneProduct ncbigene:3451 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA14 GeneProduct ncbigene:3448 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA4 GeneProduct ncbigene:3441 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA1 GeneProduct ncbigene:3439 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA13 GeneProduct ncbigene:3447 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA5 GeneProduct ncbigene:3442 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA6 GeneProduct ncbigene:3443 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNB1 GeneProduct ncbigene:3456 Original kegg element: gene;1;hsa:3456
TBK1 GeneProduct ensembl:ENSG00000183735
IKBKE GeneProduct ensembl:ENSG00000263528
CGAS GeneProduct ensembl:ENSG00000164430
DDX58 GeneProduct ensembl:ENSG00000107201
TRIM25 GeneProduct ensembl:ENSG00000121060
CYLD GeneProduct ensembl:ENSG00000083799
RNF125 GeneProduct ensembl:ENSG00000101695
ISG15 GeneProduct ensembl:ENSG00000187608
ATG5 GeneProduct ensembl:ENSG00000057663
ATG12 GeneProduct ensembl:ENSG00000145782
NLRX1 GeneProduct ensembl:ENSG00000160703
MAVS GeneProduct ensembl:ENSG00000088888
TMEM173 GeneProduct ensembl:ENSG00000184584
TRADD GeneProduct ensembl:ENSG00000102871
FADD GeneProduct ensembl:ENSG00000168040
RIPK1 GeneProduct ensembl:ENSG00000137275
CASP8 GeneProduct ensembl:ENSG00000064012
CASP10 GeneProduct ensembl:ENSG00000003400
CCL4 GeneProduct ensembl:ENSG00000275302

References

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